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General Review Article

Comparison of Cell-based and Nanoparticle-based Therapeutics in Treating Atherosclerosis

Author(s): Wen Xi Goh, Yih Yih Kok* and Chiew Yen Wong

Volume 29, Issue 35, 2023

Published on: 03 November, 2023

Page: [2827 - 2840] Pages: 14

DOI: 10.2174/0113816128272185231024115046

Price: $65

Abstract

Today, cardiovascular diseases are among the biggest public health threats worldwide. Atherosclerosis, a chronic inflammatory disease with complex aetiology and pathogenesis, predispose many of these conditions, including the high mortality rate-causing ischaemic heart disease and stroke. Nevertheless, despite the alarming prevalence and absolute death rate, established treatments for atherosclerosis are unsatisfactory in terms of efficacy, safety, and patient acceptance. The rapid advancement of technologies in healthcare research has paved new treatment approaches, namely cell-based and nanoparticle-based therapies, to overcome the limitations of conventional therapeutics. This paper examines the different facets of each approach, discusses their principles, strengths, and weaknesses, analyses the main targeted pathways and their contradictions, provides insights on current trends as well as highlights any unique mechanisms taken in recent years to combat the progression of atherosclerosis.

Keywords: Atherosclerosis, cell-based therapy, nanoparticle-based therapy, cardiovascular diseases, chronic inflammatory disease, complex aetiology.

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