Learning objectives
The purpose of this poster is to review the most common histopathologic processes underlying drug toxicity lung injury (DILD), describe and illustrate the radiological manifestations on HRCT based on our experience.
Background
Drug-induced lung injury is a frequent cause of acute, subacute and chronic lung pathology and is most often caused by cytotoxic drugs.
The prevalence of chemotherapy-induced lung toxicity is increasing with the introduction of new potentially pneumotoxic drugs. The lung lesion can be progressive, so early diagnosis is essential.
The diagnosis of toxicity pneumopathy is of exclusion, and forces to rule out other processes that may coexist especially in the cancer patient.
Radiological findings are usually associated with the underlying histological pattern although some patients...
Findings and procedure details
The histological abnormalities diseases that characterize drug-induced lung injury generally involve the pulmonary interstitium.
Drugs can produce all histopathological patterns of interstitial pneumonia and include diffuse alveolar damage, nonspecific interstitial pneumonia and organizing pneumonia as the most frequent; eosinophilic pneumonia, pulmonary edema o hemorrhage, and hypersensitivity pneumonia are less common.
DIFFUSE ALVEOLAR DAMAGE (DAD)
It is the most frequent manifestation of histologically confirmed lung toxicity.
It is a manifestation of pulmonary toxicity secondary to necrosis of type II pneumocytes and alveolar endothelial cells.
The drugs...
Conclusion
The prevalence of DILD is increasing by the use of new drugs. The radiologic features are not specific and often difficult to distinguish from other causes of diffuse lung disease so keep on mind the possibility of DILD and make an early diagnosis at-risk patients.
Personal information and conflict of interest
S. de la Mano González; Salamanca/ES - nothing to disclose J. C. Paniagua; Salamanca/ES - nothing to disclose P. H. Garcia; Salamanca/ES - nothing to disclose P. Arias Rodriguez; Salamanca/ES - nothing to disclose M. Garzon Guiteria; Salamanca/ES - nothing to disclose B. Prieto García; Salamanca/ES - nothing to disclose S. Yañez Castaño; Salamanca/ES - nothing to disclose S. Marquez Batalla; Salamanca/ES - nothing to disclose R. Rodríguez Vázquez; Salamanca/ES - nothing to disclose
References
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Nishiyama O, Kondoh Y, Taniguchi H, et al. Serial high resolution CT findings in nonspecific interstitial pneumonia/fibrosis. J Comput Assist Tomogr 2000; 24: 41-6.
Webb WR, Muller NL, Naidich DP. High resolution ct of the lung.Fourth Edition Ed. LWW. Drug induced lung diseases: 356-362.
Hansell DM, Armstrong P, Lynch DA, Mc Adams HP.Chest: Radiological Diagnosis. Drug Induced Lung Disease. Ed. Marban.2007: 427-441....