Purpose
The Prostatic Cancer (PCa) diagnostic procedure needs a non-invasive instrumental investigation able to provide an accurate risk stratification, that is extremely important to start an appropriate therapeutic protocol or active surveillance. Neither Prostate Specific Antigen (PSA), nor transrectal ultrasound-guided biopsy allows an accurate stratification of the neoplastic risk [1-2].
The aim of this study is to demonstrate the inverse correlation between the ADC value and the Gleason Score (GS) of prostatic lesions, to analyze the distribution of ADC values for GS7, and to define an...
Methods and materials
We retrospectively identified 68 patients (recruited from December 2016 to October 2018) with histological diagnosis of CPa and mp-MRI performed
at our department. The patients’ average age was 72 years (range 47-82 years). All patients who performed radiotherapy or chemotherapy treatments before histological or mp-MRI evaluation were excluded. All MRI examinations were performed using a 1,5 T MR scanner (Philips Healthcare, Best, Netherlands). Two experienced radiologists independently assessed MR images evaluating DWI (diffusion weightedimaging), T2W sequences and ADC maps, and reported according to PI-RADS v2...
Results
The study showed statistically significant difference between ADC values of the lesions and healthy parenchyma (p
Conclusion
Our data confirmed the ADC value capacity to evaluate the biological activity of prostatic lesions, with possible implications in terms of active surveillance and assessment of radiotherapy treatment response [6-9].
Personal information and conflict of interest
E. Cotti; Ferrara/IT - nothing to disclose G. Parenti; Ravenna/IT - nothing to disclose A. Clarizia; Cona (FE)/IT - nothing to disclose L. Mellini; Ferrara/IT - nothing to disclose A. Carnevale; Ferrara/IT - nothing to disclose R. Galeotti; Ferrara (FE)/IT - nothing to disclose
References
1. Cookson MS, Fleshner NE, Soloway SM, Fair WR. Correlation between Gleason score of needle biopsy and radical prostatectomy specimen: accuracy and clinical implications. J Urol. 1997;157(2):559–562. doi: 10.1016/S0022- 5347(01)65201-7.
2. Futterer JJ, Briganti A, De Visschere P, Emberton M, Giannarini G, Kirkham A, et al. Can clinically significant prostate cancer be detected with multiparametric magnetic resonance imaging? A Systematic Review of the Literature. Eur Urol. 2015;68:1045–1053.
3. PI-RADS v2. (2015). American College of Radiology.
4. Deanna LLanger, Theodorus H, Andrew J, Anna Plotkin e...