Welcome to Francis Academic Press

International Journal of Frontiers in Medicine, 2022, 4(2); doi: 10.25236/IJFM.2022.040203.

Relationship between CAF and NF-produced Exosomes and Their Specific Biomolecules in EMT of Oral Squamous Cell Carcinoma Cells and Meta-Analysis

Author(s)

Weiyue Gao

Corresponding Author:
Weiyue Gao
Affiliation(s)

Oral Clinical Medicine Centre, Gansu Provincial Hospital, Lanzhou 730000, China

Abstract

Oral squamous cell carcinoma is a common cancer characterized by varying degrees of squamous differentiation, and the most ideal treatment is to take "three early" measures, namely early detection, early diagnosis, and early treatment, so as to improve the survival rate of patients. Improve quality of life. This paper mainly studies the relationship and meta-analysis of the exosomes produced by CAF and NF and their specific biomolecules in EMT of oral squamous cell carcinoma, hoping to find the relationship between them to help doctors diagnose oral squamous cell carcinoma. For this study, a detailed overview of CAF, a cell population closely associated with cancer, oral squamous cell carcinoma cells and EMT was firstly performed, and a detection model of oral squamous cell carcinoma cells was also established, and the spread of cells in the oral cavity was parallel to the The orientation of neuronal fibers was de-sampled. Oral incision biopsies of clinically detected OSF and OSCC were then stained and cells were examined using scanning electron microscopy. In the final experimental results, it can be found that there is an 80% chance that the patient's cells have epithelial-mesenchymal transition (EMT) to have oral squamous cell carcinoma.

Keywords

Relationship and Meta-Analysis of CAF and NF; Oral Squamous Cell Carcinoma Cells; EMT Relationship; Meta Analysis

Cite This Paper

Weiyue Gao. Relationship between CAF and NF-produced Exosomes and Their Specific Biomolecules in EMT of Oral Squamous Cell Carcinoma Cells and Meta-Analysis. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 2: 10-15. https://doi.org/10.25236/IJFM.2022.040203.

References

[1] Ling Z, Cheng B, Tao X. Epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma: Challenges and opportunities [J]. International Journal of Cancer, 2021, 148(7): 1548-1561.

[2] Ghuwalewala S, Ghatak D, Das P, et al. CD44highCD24low molecular signature determines the cancer stem cell and EMT phenotype in oral squamous cell carcinoma[J]. Stem cell research, 2017, 16(2): 405-417.

[3] Kim S, Lee K H, Lee D H, et al. Receptor tyrosine kinase, RON, promotes tumor progression by regulating EMT and the MAPK signaling pathway in human oral squamous cell carcinoma[J]. International journal of oncology, 2019, 55(2): 513-526.

[4] Kisoda S, Shao W, Fujiwara N, et al. Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis[J]. Oral diseases, 2020, 26(6): 1149-1156.

[5] Zhang J, Zheng G, Zhou L, et al. Notch signalling induces epithelial mesenchymal transition to promote metastasis in oral squamous cell carcinoma [J]. International journal of molecular medicine, 2018, 42(4): 2276-2284.

[6] Wangmo C, Charoen N, Jantharapattana K, et al. Epithelial–mesenchymal transition predicts survival in oral squamous cell carcinoma [J]. Pathology & Oncology Research, 2020, 26(3): 1511-1518.

[7] Xie S L, Fan S, Zhang S Y, et al. SOX8 regulates cancer stem‐like properties and cisplatin‐induced EMT in tongue squamous cell carcinoma by acting on the Wnt/β‐catenin pathway[J]. International journal of cancer, 2018, 142(6): 1252-1265.

[8] Ricci S, Pinto F, Auletta A, et al. The enigmatic role of matrix metalloproteinases in epithelial‐to‐mesenchymal transition of oral squamous cell carcinoma: Implications and nutraceutical aspects [J]. Journal of cellular biochemistry, 2019, 120(5): 6813-6819.

[9] Arunkumar G, Deva Magendhra Rao A K, Manikandan M, et al. Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma[J]. Oncology letters, 2018, 15(1): 649-657.

[10] Boxberg M, Leising L, Steiger K, et al. Composition and clinical impact of the immunologic tumor microenvironment in oral squamous cell carcinoma[J]. The Journal of Immunology, 2019, 202(1): 278-291.