Abstract
Background: The Present work describe the synthetic protocol of a new series of 2-(4-(2-(5- Ethylpyridin-2-yl)ethoxy)phenyl)-4-(4-substituted)-2,3-dihydrobenzo [b][1,4]thiazepine (5a-j) by the cyclization of chalcones (4a-j) with 2-amino thiophenol by microwave induced solvent free conditions as well as conventional approach.
Methods: The elemental analysis and spectral method (IR, 1H and 13C NMR) were characterized the structure of all synthesized compounds.
Result: These compounds were screened for antibacterial and antifungal activity. Bezothiazepine derivative 5f showed potency (MBC = 50 µg/ml) against gram negative P. aeruginosa and 5i displyed encouraging activity (MFC = 200 µg/ml) against A. niger and A. clavatus.
Conclusion: The solvent less non-conventional microwave induced synthesis of compound (5a-j) has been proven considerable advantageous over conventional methods.
Keywords: Antibacterial, antifungal, benzothiazepine, chalcone, microwave, solvent-free.
Current Microwave Chemistry
Title:Microwave Assisted Synthetic Approach of New Pyridine based Benzothiazepines: Their Antibacterial and Antifungal Activities
Volume: 3 Issue: 3
Author(s): Navin B. Patel, Hemant R. Patel, Faiyazalam M. Shaikh, Dhanji P. Rajani and Vatsal M. Patel
Affiliation:
Keywords: Antibacterial, antifungal, benzothiazepine, chalcone, microwave, solvent-free.
Abstract: Background: The Present work describe the synthetic protocol of a new series of 2-(4-(2-(5- Ethylpyridin-2-yl)ethoxy)phenyl)-4-(4-substituted)-2,3-dihydrobenzo [b][1,4]thiazepine (5a-j) by the cyclization of chalcones (4a-j) with 2-amino thiophenol by microwave induced solvent free conditions as well as conventional approach.
Methods: The elemental analysis and spectral method (IR, 1H and 13C NMR) were characterized the structure of all synthesized compounds.
Result: These compounds were screened for antibacterial and antifungal activity. Bezothiazepine derivative 5f showed potency (MBC = 50 µg/ml) against gram negative P. aeruginosa and 5i displyed encouraging activity (MFC = 200 µg/ml) against A. niger and A. clavatus.
Conclusion: The solvent less non-conventional microwave induced synthesis of compound (5a-j) has been proven considerable advantageous over conventional methods.
Export Options
About this article
Cite this article as:
Patel B. Navin, Patel R. Hemant, Shaikh M. Faiyazalam, Rajani P. Dhanji and Patel M. Vatsal, Microwave Assisted Synthetic Approach of New Pyridine based Benzothiazepines: Their Antibacterial and Antifungal Activities, Current Microwave Chemistry 2016; 3 (3) . https://dx.doi.org/10.2174/2213335603666160609123550
DOI https://dx.doi.org/10.2174/2213335603666160609123550 |
Print ISSN 2213-3356 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3364 |
Call for Papers in Thematic Issues
Microwave Technology: Advancements and Applications in Chemistry, Environment and Food Science
Microwave technology has emerged as a transformative tool in various fields, offering unique opportunities for rapid, efficient, and clean processes. This thematic issue aims to encapsulate the latest research, innovative strategies, and progressive methodologies concerning the application of microwave technology in three main areas: Chemistry: Highlighting the advancements in microwave-assisted ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Efficacy of Chemopreventive Agents in Mouse Mammary Gland Organ Culture (MMOC) Model: A Comprehensive Review
Current Medicinal Chemistry Recent Patents Concerning Modulators of Protein Kinase C
Recent Patents on DNA & Gene Sequences Subject Index to Volume 10
Current Medicinal Chemistry Actinomycetes as a Paramount Source of Biologically Important Enzyme Inhibitors – “A Boon to Mankind”
Current Bioactive Compounds Phytochemicals and Cancer Stem Cells: A Pancreatic Cancer Overview
Current Chemical Biology Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry A Wnt-ow of Opportunity: Targeting the Wnt/β-Catenin Pathway in Breast Cancer
Current Drug Targets Healthy Diet and Reduction of Chronic Disease Risks of Night Shift Workers
Current Medicinal Chemistry Is there a Potential Immune Dysfunction with Anabolic Androgenic Steroid Use?: A Review
Mini-Reviews in Medicinal Chemistry Design, Synthesis, Anti-Proliferative, Anti-microbial, Anti-Angiogenic Activity and In Silico Analysis of Novel Hydrazone Derivatives
Anti-Cancer Agents in Medicinal Chemistry Defective HIF Signaling Pathway and Brain Response to Hypoxia in Neurodegenerative Diseases: Not an “Iffy” Question!
Current Pharmaceutical Design Synthesis and Evaluation of a Novel Gene Reporter Molecule: Detection of b-galactosidase Activity Using 19F NMR of a Fluorinated Vitamin B6 Conjugate+
Medicinal Chemistry FOXO and FOXM1 in Cancer: The FOXO-FOXM1 Axis Shapes the Outcome of Cancer Chemotherapy
Current Drug Targets Role of Progesterone in Human Astrocytomas Growth
Current Topics in Medicinal Chemistry The Sea Urchin, Paracentrotus lividus, as a Model to Investigate the Onset of Molecules Immunologically Related to the α-7 Subunit of Nicotinic Receptors During Embryonic and Larval Development
Current Drug Targets Human-Derived Organ-on-a-Chip for Personalized Drug Development
Current Pharmaceutical Design Transcriptional Analysis of JAK/STAT Signaling in Glioblastoma Multiforme
Current Pharmacogenomics and Personalized Medicine Anticancer Drug Design Using Scaffolds of β-Lactams, Sulfonamides, Quinoline, Quinoxaline and Natural Products. Drugs Advances in Clinical Trials
Current Medicinal Chemistry Nonstandard Drugs and Feasible New Interventions for Autoimmune Hepatitis: Part II
Inflammation & Allergy - Drug Targets (Discontinued) CXCL8 as a Potential Therapeutic Target for HIV-Associated Neurocognitive Disorders
Current Drug Targets