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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Mini-Review Article

Tirzepatide: A New Generation Therapeutic for Diabetes Type 2

Author(s): Rami A. Al-Horani* and Milad Chedid

Volume 23, Issue 8, 2023

Published on: 22 February, 2023

Page: [1046 - 1050] Pages: 5

DOI: 10.2174/1871530322666221004151212

Price: $65

Abstract

Tirzepatide (mounjaro®) is a derivative of the human glucose-dependent insulinotropic polypeptide (GIP) hormone with a position-20 being modified with 1,20- eicosanedioic acid via a chemical linker. It acts as a glucagon-like peptide-1 (GLP-1) receptor and GIP receptor agonist. It has recently been approved by FDA as an adjunct therapy to exercise and diet to improve glycemic control in patients with type II diabetes mellitus (T2DM). It represents a new transforming paradigm in the management of T2DM. This mini-review will shed light on its different pharmacokinetic and pharmacodynamic aspects.

Keywords: Tirzepatide, T2DM, GLP-1, GIP, Semaglutide, Dulaglutide.

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Graphical Abstract

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