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Anti-Cancer Agents in Medicinal Chemistry

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ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

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Review Article

Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment

Author(s): Asmat Ullah*, Najeeb Ullah, Touseef Nawaz and Tariq Aziz*

Volume 23, Issue 7, 2023

Published on: 19 September, 2022

Page: [765 - 778] Pages: 14

DOI: 10.2174/1871520622666220831124321

Price: $65

Abstract

Historically, natural plant-derived drugs received a great impact of consideration in the treatment of several human-associated disorders. Cancer is a devastating disease and the second most cause of mortality. Sanguinarine (SANG), a naturally isolated plant alkaloidal agent, possesses chemo-preventive effects. Several studies have revealed that SANG impedes tumor metastasis and development by disrupting a wide range of cell signaling pathways and its molecular targets, such as BCL-2, MAPKs, Akt, NF-κB, ROS, and microRNAs (miRNAs). However, its low chemical stability and poor oral bioavailability remain key issues in its use as a medicinal molecule. A novel method (e.g., liposomes, nanoparticles, and micelles) and alternative analogs provide an exciting approach to alleviate these problems and broaden its pharmacokinetic profile. Cancer-specific miRNA expression is synchronized by SANG, which has also been uncertain. In this critical study, we review the utilization of SANG mimics and nano-technologies to improve its support in cancer. We focus on recently disclosed studies on SANG anti-cancer properties.

Keywords: Sanguinarine, cancer, natural agent, nanoparticle, molecular target, chemo-preventive effects.

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