Abstract
The ability to deliver therapeutic agents to a patient in a pulsatile or staggered release profile has been a major goal in drug delivery research. Smart polymeric materials display a dramatic physiochemical changes in their properties to small changes in their environment (stimuli) e.g. temperature, light, pH. This behaviour can be utilised for the preparation of ‘smart’ or ‘intelligent’ drug delivery systems, which mimic biological response behaviour to a certain extent. The present review focuses on externally (pulsatile) and internally (self regulated) controlled systems which include a range of technologies like pre-programmed systems as well as systems that are sensitive to stimuli like pH, magnetic fields, glucose, ultrasounds, electric fields, temperature, light and mechanical stimulation. Knowledge of smart polymeric material, stimuli & adaptive properties are useful to develop smart drug delivery system.
Keywords: Smart polymers, stimuli, smart drug delivery, pulsatile, self regulated, adaptive properties, Environmental stimuli, photochromic material, bioconjugated system, hypoxia, sol-gel, entropic effects, Enthalpic effects, ferrogels, Photostimulated Sysems, chromophore, hydrogel
Current Drug Therapy
Title: Smart Polymers and Their Role in Drug Delivery: A Review
Volume: 5 Issue: 4
Author(s): Kisan R. Jadhav, Sharad S. Pacharane, Praveen V. Koshy and Vilasrao J. Kadam
Affiliation:
Keywords: Smart polymers, stimuli, smart drug delivery, pulsatile, self regulated, adaptive properties, Environmental stimuli, photochromic material, bioconjugated system, hypoxia, sol-gel, entropic effects, Enthalpic effects, ferrogels, Photostimulated Sysems, chromophore, hydrogel
Abstract: The ability to deliver therapeutic agents to a patient in a pulsatile or staggered release profile has been a major goal in drug delivery research. Smart polymeric materials display a dramatic physiochemical changes in their properties to small changes in their environment (stimuli) e.g. temperature, light, pH. This behaviour can be utilised for the preparation of ‘smart’ or ‘intelligent’ drug delivery systems, which mimic biological response behaviour to a certain extent. The present review focuses on externally (pulsatile) and internally (self regulated) controlled systems which include a range of technologies like pre-programmed systems as well as systems that are sensitive to stimuli like pH, magnetic fields, glucose, ultrasounds, electric fields, temperature, light and mechanical stimulation. Knowledge of smart polymeric material, stimuli & adaptive properties are useful to develop smart drug delivery system.
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Cite this article as:
R. Jadhav Kisan, S. Pacharane Sharad, V. Koshy Praveen and J. Kadam Vilasrao, Smart Polymers and Their Role in Drug Delivery: A Review, Current Drug Therapy 2010; 5 (4) . https://dx.doi.org/10.2174/157488510792927456
DOI https://dx.doi.org/10.2174/157488510792927456 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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