Abstract
The maintenance of pancreatic β-cells normal functioning is crucial for insulin production and glucose homeostasis. Inadequate insulin secretion due to β-cell dysfunction can lead to different types of diabetes mellitus. Though it is widely recognized that both environmental and genetic factors play important roles, the exact molecular mechanism that leads to β -cell failure is still unclear. MicroRNAs (miRNAs) regulate numerous physiological and pathophysiological processes at the epigenetic level. miRNAs have been reported to participate in the process of pancreatic development and insulin biosynthesis. Some miRNAs may control insulin secretion and exocytosis through regulating ATP/ADP ratio. In this review, we will summarize the pathological roles of miRNAs in β-cell dysfunction and briefly discuss miRNAs as possible biomarkers and potential pharmaceutical target for diabetes mellitus.
Current Signal Transduction Therapy
Title:MicroRNAs in Diabetic β Cell Dysfunction and their Role as Biomarkers
Volume: 9 Issue: 2
Author(s): Yaxi Chen, Haoming Tian and Xijie Yu
Affiliation:
Keywords: Biomarker, β cells, diabetes, insulin, miRNAs.
Abstract: The maintenance of pancreatic β-cells normal functioning is crucial for insulin production and glucose homeostasis. Inadequate insulin secretion due to β-cell dysfunction can lead to different types of diabetes mellitus. Though it is widely recognized that both environmental and genetic factors play important roles, the exact molecular mechanism that leads to β -cell failure is still unclear. MicroRNAs (miRNAs) regulate numerous physiological and pathophysiological processes at the epigenetic level. miRNAs have been reported to participate in the process of pancreatic development and insulin biosynthesis. Some miRNAs may control insulin secretion and exocytosis through regulating ATP/ADP ratio. In this review, we will summarize the pathological roles of miRNAs in β-cell dysfunction and briefly discuss miRNAs as possible biomarkers and potential pharmaceutical target for diabetes mellitus.
Export Options
About this article
Cite this article as:
Chen Yaxi, Tian Haoming and Yu Xijie, MicroRNAs in Diabetic β Cell Dysfunction and their Role as Biomarkers, Current Signal Transduction Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574362410666150114230309
DOI https://dx.doi.org/10.2174/1574362410666150114230309 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Endothelial Function and Pathogenesis of Endothelial Dysfunction
Current Immunology Reviews (Discontinued) Editorial: Modifying Cardiovascular Risk Factors: Acquired Topics and Emerging Concepts
Current Pharmaceutical Design Oral Cavity-Associated Immune System: What is New?
Current Immunology Reviews (Discontinued) Malignant Hypertension: A Rare Problem or is it Underdiagnosed?
Current Vascular Pharmacology Homocysteine: A Risk Factor in Patietns with Cardiovascular Disorders in Pakistan
Current Bioactive Compounds Effects of Antiplatelet Medication on Arteriovenous Fistula Patency After Surgical Thrombectomy
Current Vascular Pharmacology microRNA as Biomarkers and Regulator of Cardiovascular Development and Disease
Current Pharmaceutical Design PDE5 Inhibitors: In Vitro and In Vivo Pharmacological Profile
Current Pharmaceutical Design Role of Heat Shock Proteins in Atherosclerosis and Atrial Fibrillation
Current Immunology Reviews (Discontinued) Potential Role of TRAIL in the Management of Autoimmune Diabetes Mellitus
Current Pharmaceutical Design Cholinesterases: Roles in the Brain During Health and Disease
Current Alzheimer Research Role of Platelet Function Testing in Clinical Practice: Current Concepts and Future Perspectives
Current Drug Targets Does Perioperative Hemoglobin A1c Level Affect the Incidence, Pattern and Mortality of Lower Extremity Amputation?
Current Vascular Pharmacology The Battle of the Sexes for Stroke Therapy: Female- Versus Male-Derived Stem Cells
CNS & Neurological Disorders - Drug Targets The Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway as a Therapeutic Target for the Treatment of Human Acute Myeloid Leukemia (AML)
Current Signal Transduction Therapy The Application of Minerals in Managing Alcohol Hangover: A Preliminary Review
Current Drug Abuse Reviews Treatment of Insulin Resistance in the Neurodegeneration
Recent Patents on CNS Drug Discovery (Discontinued) Placental Hypoxia Developed During Preeclampsia Induces Telocytes Apoptosis in Chorionic Villi Affecting The Maternal-Fetus Metabolic Exchange
Current Stem Cell Research & Therapy Hydroethanolic Extract of <i>Lampaya Medicinalis</i> Phil. (<i>Verbenaceae</i>) Decreases Proinflammatory Marker Expression in Palmitic Acid-exposed Macrophages
Endocrine, Metabolic & Immune Disorders - Drug Targets Clinical Perspectives on Antidepressant Drug Development: A Critical Discussion
Current Pharmaceutical Design