Abstract
Cyclovirobuxine D is an active steroid alkaloid distributed in Buxus microphylla and applied in therapeutic practice of cardiovascular disease. This study describes the development of a new CRM, which includes the homogeneity assessment, stability assessment, purity determination, and uncertainty evaluation. DSC method was applied to the value assignment of cyclovirobuxine D for the first time. The certified purity value for the CRM of cyclovirobuxine D is 996.6 mg•g-1 with an extended uncertainty of 0.6 mg•g-1 (k = 2, P = 0.95) by DSC method. The CRM of cyclovirobuxine D can be widely used to quantitative analyses of cyclovirobuxine D and other related pharmaceutical formulations.
Keywords: Cyclovirobuxine D, DSC, value assignment, uncertainty evaluation, CRM, homogeneity study, stability study.
Current Analytical Chemistry
Title:Value Assignment Study on a New Certified Reference Material of Cyclovirobuxine D by Differential Scanning Calorimetry Method
Volume: 12 Issue: 6
Author(s): Li Zhang, Yang Lu, Yonghui Guo, Wei Xu, Guimin Jin and Guanhua Du
Affiliation:
Keywords: Cyclovirobuxine D, DSC, value assignment, uncertainty evaluation, CRM, homogeneity study, stability study.
Abstract: Cyclovirobuxine D is an active steroid alkaloid distributed in Buxus microphylla and applied in therapeutic practice of cardiovascular disease. This study describes the development of a new CRM, which includes the homogeneity assessment, stability assessment, purity determination, and uncertainty evaluation. DSC method was applied to the value assignment of cyclovirobuxine D for the first time. The certified purity value for the CRM of cyclovirobuxine D is 996.6 mg•g-1 with an extended uncertainty of 0.6 mg•g-1 (k = 2, P = 0.95) by DSC method. The CRM of cyclovirobuxine D can be widely used to quantitative analyses of cyclovirobuxine D and other related pharmaceutical formulations.
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Cite this article as:
Zhang Li, Lu Yang, Guo Yonghui, Xu Wei, Jin Guimin and Du Guanhua, Value Assignment Study on a New Certified Reference Material of Cyclovirobuxine D by Differential Scanning Calorimetry Method, Current Analytical Chemistry 2016; 12 (6) . https://dx.doi.org/10.2174/1573411011666150918190217
DOI https://dx.doi.org/10.2174/1573411011666150918190217 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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