Abstract
An efficient and environmentally benign one- pot four-component domino protocol has been presented for the synthesis of structurally diverse spirooxindoles spiroannulated with chromenopyrazolophthalazines, indazolophthalazines and pyranopyrazolophthalazines involving the reaction of phthalic anhydride, hydrazine hydrate, isatins and cyclic ketones in aqueous alcoholic medium (H2O-C2H5OH: v 5:1) using catalytic amount of sulphamic acid.
Keywords: Chromenopyrazolophthalazines, indazolophthalazines, multicomponent reactions, pyranopyrazolophthalazines, spiroheterocycles, spirooxindoles.
Current Bioactive Compounds
Title:An Efficient and Environmentally Benign Four-component Domino Protocol for Synthesis of Spirooxindoles Spiroannulated with Fused Heterosystems of Privileged Heterocycles
Volume: 9 Issue: 3
Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar
Affiliation:
Keywords: Chromenopyrazolophthalazines, indazolophthalazines, multicomponent reactions, pyranopyrazolophthalazines, spiroheterocycles, spirooxindoles.
Abstract: An efficient and environmentally benign one- pot four-component domino protocol has been presented for the synthesis of structurally diverse spirooxindoles spiroannulated with chromenopyrazolophthalazines, indazolophthalazines and pyranopyrazolophthalazines involving the reaction of phthalic anhydride, hydrazine hydrate, isatins and cyclic ketones in aqueous alcoholic medium (H2O-C2H5OH: v 5:1) using catalytic amount of sulphamic acid.
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Cite this article as:
Khandelwal Sarita, Rajawat Anshu and Kumar Mahendra, An Efficient and Environmentally Benign Four-component Domino Protocol for Synthesis of Spirooxindoles Spiroannulated with Fused Heterosystems of Privileged Heterocycles, Current Bioactive Compounds 2013; 9 (3) . https://dx.doi.org/10.2174/15734072113099990014
DOI https://dx.doi.org/10.2174/15734072113099990014 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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