A New 1,2,4-Triazole Acyclonucleosides: Synthesis and Biological Evaluation

Title: A New 1,2,4-Triazole Acyclonucleosides: Synthesis and Biological Evaluation

Volume: 4 Issue: 3

Author(s): Smaail Radi and Hassan B. Lazrek

Affiliation:

Keywords: Nucleoside, Triazole, Catalysis, Antiviral, Ribavirin, Acyclovir

Abstract: Two new regioisomers acyclonucleosides bearing 1,2,4-triazole rings as the base moiety were synthesised with aliphatic side chain [(2-acetoxyethoxy)methyl]-bromide under solid-liquid phase transfer catalysis (S.L.P.T.C.) and under silylation method. Biological evaluation of all product revealed they were inactive against various RNA and DNA viruses in cell cultures. Structure activity relationship studies (SAR) indicate that introduction of acyclovir arm in N1 or N2 position of 1,2,4-triazole has not any impact on the antiviral activity.

Cite this article as:

Radi Smaail and Lazrek B. Hassan, A New 1,2,4-Triazole Acyclonucleosides: Synthesis and Biological Evaluation, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077372