Abstract
The use of bismuth(III) salts in organic synthesis has attracted an increasing interest over the last years. Systems comprising of bismuth(III) salts are generally catalytic and involve a relatively non-toxic metal. These features are of great interest in the area of green and pharmaceutical chemistry. Due to the fact a large number of natural compounds and known drugs are heterocycles, their construction and/or functionalization is of major interest. This review will focus on the uses of bismuth(III) salts in heterocyclic chemistry, as applied to the synthesis of compounds of pharmaceutical interest. In addition to the inclusion of five- and six-membered heterocycles, five- and six-membered heterocycles fused to one benzene ring, as well as other heterocyclic compounds, the application of bismuth(III) salts to chemistry of carbohydrates, nucleosides and β-lactams will also be considered.
Keywords: Bismuth(III) salts, heterocycles, pharmaceutical interest, green chemistry
Current Organic Synthesis
Title: Recent Advances of Bismuth(III) Salts in Organic Chemistry: Application to the Synthesis of Heterocycles of Pharmaceutical Interest
Volume: 6 Issue: 4
Author(s): Jorge A.R. Salvador, Rui M.A. Pinto and Samuel M. Silvestre
Affiliation:
Keywords: Bismuth(III) salts, heterocycles, pharmaceutical interest, green chemistry
Abstract: The use of bismuth(III) salts in organic synthesis has attracted an increasing interest over the last years. Systems comprising of bismuth(III) salts are generally catalytic and involve a relatively non-toxic metal. These features are of great interest in the area of green and pharmaceutical chemistry. Due to the fact a large number of natural compounds and known drugs are heterocycles, their construction and/or functionalization is of major interest. This review will focus on the uses of bismuth(III) salts in heterocyclic chemistry, as applied to the synthesis of compounds of pharmaceutical interest. In addition to the inclusion of five- and six-membered heterocycles, five- and six-membered heterocycles fused to one benzene ring, as well as other heterocyclic compounds, the application of bismuth(III) salts to chemistry of carbohydrates, nucleosides and β-lactams will also be considered.
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Cite this article as:
Salvador A.R. Jorge, Pinto M.A. Rui and Silvestre M. Samuel, Recent Advances of Bismuth(III) Salts in Organic Chemistry: Application to the Synthesis of Heterocycles of Pharmaceutical Interest, Current Organic Synthesis 2009; 6 (4) . https://dx.doi.org/10.2174/157017909789108701
DOI https://dx.doi.org/10.2174/157017909789108701 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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