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Current Topics in Medicinal Chemistry

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Research Article

Investigating Biomarkers for COVID-19 Morbidity and Mortality

Author(s): Flavio Maria Ceci, Giampiero Ferraguti, Marco Lucarelli, Antonio Angeloni, Enea Bonci, Carla Petrella, Silvia Francati, Christian Barbato, Maria Grazia Di Certo, Francesca Gabanella, Francesca Gavaruzzi, Claudio Maria Mastroianni, Antonio Minni, Antonio Greco, Massimo Ralli, Mauro Ceccanti, Luigi Tarani and Marco Fiore*

Volume 23, Issue 13, 2023

Published on: 20 March, 2023

Page: [1196 - 1210] Pages: 15

DOI: 10.2174/1568026623666230222094517

Price: $65

Abstract

Background and Objectives: This retrospective study aims to disclose further early parameters of COVID-19 morbidity and mortality.

Methods: Three hundred and eighty-two COVID-19 patients, recruited between March and April 2020, were divided into three groups according to their outcome: (1) hospital ward group (patients who entered the hospital wards and survived); (2) intensive care unit (ICU) group (patients who attended the ICU and survived); (3) the deceased group (patients admitted to ICU with a fatal outcome). We investigated routine laboratory parameters such as albumin, glycemia, hemoglobin amylase, lipase, AST, ALT, GGT, LDH, CK, MGB, TnT-hs, IL-6, ferritin, CRP, PCT, WBC, RBC, PLT, PT, INR, APTT, FBG, and D-dimer. Blood withdrawal was carried out at the beginning of the hospitalization period.

Results: ANOVA and ROC data evidenced that the concomitant presence of alterations in albumin, lipase, AST, ALT, LDH, MGB, CK, IL-6, ferritin in women, CRP and D-dimer is an early sign of fatal outcomes.

Conclusion: The present study confirms and extends the validity of routine laboratory biomarkers (i.e., lipase, AST, ALT, LDH, CK, IL-6, ferritin in women, CRP and D-dimer) as indicators of COVID-19 morbidity and mortality. Furthermore, the investigation suggests that both gross changes in albumin and MGB, markers of liver and heart damage, may early disclose COVID-19 fatal outcomes.

Keywords: SARS-CoV-2, COVID-19, Albumin, Myoglobin, Early predictor, Biomarker.

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