Abstract
Many structural modifications have been made on the naturally occurring nucleosides in the search for medicinal agents that will interfere with the utilization of the natural compounds. One such area of pursuit has been the replacement of the oxygen of the ribofuranose ring of common nucleosides with a methylene unit (resulting in a cyclopentyl ring) leading to biologically meaningful carbanucleosides (carbocyclic nucleosides). This review calls attention to new methods for preparing these compounds in enantiomeric forms with various heterocyclic bases and ring contracted and expanded cyclopentyl substituents.
Keywords: carbocyclic nucleosides, structural modifications, expanded cyclopentyl substituents, synthetic considerations, bicycliclactam, cyclopentyl ring
Current Topics in Medicinal Chemistry
Title: Carbocyclic Nucleosides (Carbanucleosides) as New Therapeutic Leads
Volume: 2 Issue: 10
Author(s): Stewart W. Schneller
Affiliation:
Keywords: carbocyclic nucleosides, structural modifications, expanded cyclopentyl substituents, synthetic considerations, bicycliclactam, cyclopentyl ring
Abstract: Many structural modifications have been made on the naturally occurring nucleosides in the search for medicinal agents that will interfere with the utilization of the natural compounds. One such area of pursuit has been the replacement of the oxygen of the ribofuranose ring of common nucleosides with a methylene unit (resulting in a cyclopentyl ring) leading to biologically meaningful carbanucleosides (carbocyclic nucleosides). This review calls attention to new methods for preparing these compounds in enantiomeric forms with various heterocyclic bases and ring contracted and expanded cyclopentyl substituents.
Export Options
About this article
Cite this article as:
Schneller W. Stewart, Carbocyclic Nucleosides (Carbanucleosides) as New Therapeutic Leads, Current Topics in Medicinal Chemistry 2002; 2 (10) . https://dx.doi.org/10.2174/1568026023393228
DOI https://dx.doi.org/10.2174/1568026023393228 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
AlphaFold in Medicinal Chemistry: Opportunities and Challenges
AlphaFold, a groundbreaking AI tool for protein structure prediction, is revolutionizing drug discovery. Its near-atomic accuracy unlocks new avenues for designing targeted drugs and performing efficient virtual screening. However, AlphaFold's static predictions lack the dynamic nature of proteins, crucial for understanding drug action. This is especially true for multi-domain proteins, ...read more
Artificial intelligence for Natural Products Discovery and Development
Our approach involves using computational methods to predict the potential therapeutic benefits of natural products by considering factors such as drug structure, targets, and interactions. We also employ multitarget analysis to understand the role of drug targets in disease pathways. We advocate for the use of artificial intelligence in predicting ...read more
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effective Delivery Routes and Strategies for Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC)
Current Pharmaceutical Design Nigella Sativa Improve Redox Homeostasis in Heart and Aorta of Diabetic Rat
Current Nutrition & Food Science Pharmacological Inhibition of Protein Tyrosine Phosphatase 1B: A Promising Strategy for the Treatment of Obesity and Type 2 Diabetes Mellitus
Current Medicinal Chemistry RNA Interference as A Gene-Specific Approach for Molecular Medicine
Current Medicinal Chemistry Knockdown of C-C Chemokine Receptor 5 (CCR5) is Protective Against Cerebral Ischemia and Reperfusion Injury
Current Neurovascular Research Recent Patents and Advances in Regenerative Medicine and Stem Cell Therapies for Diabetes, Cardiovascular and Neurodegenerative Diseases
Recent Patents on Regenerative Medicine Anti-Inflammatory and Pro-Resolving Effects of N-3 PUFA in Cancers: Structures and Mechanisms
Current Topics in Medicinal Chemistry Monitoring T Cell Responses to Cancer Immunotherapy: Can We Now Identify Biomarkers Predicting Patients Who will be Responders
Current Cancer Therapy Reviews Invasive and Non-Invasive Electrical Neuromodulation in Trigeminal Nerve Neuralgia: A Systematic Review and Meta-Analysis
Current Neuropharmacology Target Product Selection - Where Can Molecular Pharming Make the Difference?
Current Pharmaceutical Design Innovative Formulations for the Controlled and Site-specific Delivery of Antiinflammatory Drugs
Current Pharmaceutical Design Gender as a Regulator of Atherosclerosis in Murine Models
Current Drug Targets Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate
Current Drug Discovery Technologies Molecular Dynamics in Esophageal Adenocarcinoma: Who’s in Control?
Current Cancer Drug Targets Adduct Formation and Context Factors in Drug Hypersensitivity: Insight from Proteomic Studies
Current Pharmaceutical Design Toll-Like Receptors: Link between “Danger” Ligands and Plaque Instability
Current Drug Targets Role, Function and Therapeutic Potential of microRNAs in Vascular Aging
Current Vascular Pharmacology AGE-RAGE System and Carcinogenesis
Current Pharmaceutical Design Innate Immunity and Primary Biliary Cirrhosis
Current Molecular Medicine Future Approaches for Treating Hematologic Disease
Current Pharmaceutical Biotechnology