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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Mini-Review Article

Therapeutic Approaches of Dual-targeted Nanomedicines for Tumor Multidrug Resistance

Author(s): Weili Han*, Zhenglin Shen, Jie Zou, Qiufang Ye, Cheng Ge, Yuqin Zhao, Ting Wang and Yafang Chen

Volume 21, Issue 2, 2024

Published on: 15 May, 2023

Page: [155 - 167] Pages: 13

DOI: 10.2174/1567201820666230504145614

Price: $65

Abstract

Currently, the main cause of cancer chemotherapy failure is multi-drug resistance (MDR), which involves a variety of complex mechanisms. Compared with traditional small-molecule chemotherapy, targeted nanomedicines offer promising alternative strategies as an emerging form of therapy, especially active targeted nanomedicines. However, although single-targeted nanomedicines have made some progress in tumor therapy, the complexity of tumor microenvironment and tumor heterogeneity limits their efficacy. Dual-targeted nanomedicines can simultaneously target two tumor-specific factors that cause tumor MDR, which have the potential in overcoming tumor MDR superior to single-targeted nanomedicines by further enhancing cell uptake and cytotoxicity in new forms, as well as the effectiveness of tumor-targeted delivery. This review discusses tumor MDR mechanisms and the latest achievements applied to dual-targeted nanomedicines in tumor MDR.

Keywords: Dual-targeted nanomedicines, multi-drug resistance (MDR), active target, tumor microenvironment, tumor heterogeneity, single-targeted nanomedicines, ABC.

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Graphical Abstract

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