Abstract
The objective of this study is to utilize the pH sensitivity of modified mesoporous silica nanoparticles (MSN) for oral delivery of insulin. Activated silica nanoparticle was modified first with different densities of 3- Chloropropyltrimethoxysilane (3-CTMS) to load the Chlor group which will bond with the organic functional group contained in 4-hydroxybenzoic acid (4-HBA). The nanoparticles were characterized by FTIR and SEM. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Insulin was entrapped in these nanoparticles and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The amount of loading of insulin was increased with increasing -COO- densities resulting from the increasing number of 4-HBA groups. In these cases, the biological activity of insulin was retained. These results were used to design and improve protein release behavior from these carriers.
Keywords: Silica nanoparticles, 4-hydroxybenzoic acid, pH-sensitive, insulin, oral drug delivery, Activated silica, 3-Chloropropyltrimethoxysilane, in vitro, swelling, release behavior, FTIR, SEM
Current Drug Delivery
Title: Synthesis and Characterization of pH-Sensitive Silica Nanoparticles for Oral-Insulin Delivery
Volume: 8 Issue: 6
Author(s): Mehrdad Mahkam
Affiliation:
Keywords: Silica nanoparticles, 4-hydroxybenzoic acid, pH-sensitive, insulin, oral drug delivery, Activated silica, 3-Chloropropyltrimethoxysilane, in vitro, swelling, release behavior, FTIR, SEM
Abstract: The objective of this study is to utilize the pH sensitivity of modified mesoporous silica nanoparticles (MSN) for oral delivery of insulin. Activated silica nanoparticle was modified first with different densities of 3- Chloropropyltrimethoxysilane (3-CTMS) to load the Chlor group which will bond with the organic functional group contained in 4-hydroxybenzoic acid (4-HBA). The nanoparticles were characterized by FTIR and SEM. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). Insulin was entrapped in these nanoparticles and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The amount of loading of insulin was increased with increasing -COO- densities resulting from the increasing number of 4-HBA groups. In these cases, the biological activity of insulin was retained. These results were used to design and improve protein release behavior from these carriers.
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Cite this article as:
Mahkam Mehrdad, Synthesis and Characterization of pH-Sensitive Silica Nanoparticles for Oral-Insulin Delivery, Current Drug Delivery 2011; 8 (6) . https://dx.doi.org/10.2174/156720111797635522
DOI https://dx.doi.org/10.2174/156720111797635522 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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