Abstract
Pyrazine is one of the important class of heterocyclic compounds that can be obtained naturally or synthesized chemically. Pyrazine ring has got importance in exhibiting various biological activities in association with other scaffolds like pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, oxazole, pyridine, piperidine and piperazine. Presence of pyrazine ring as a basic scaffold in various clinically used drugs exhibits its importance in drug design. In this review, attempt has been made to disclose various therapeutic applications of pyrazine derivatives reported during the last decade.
Keywords: Pyrazine, anti-tubercular agents, anticancer agents, diuretics, anti-diabetic agents.
Mini-Reviews in Medicinal Chemistry
Title:Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review
Volume: 13 Issue: 11
Author(s): Pankaj B. Miniyar, Prashant R. Murumkar, Pallavi S. Patil, Mahesh A. Barmade and Kailash G. Bothara
Affiliation:
Keywords: Pyrazine, anti-tubercular agents, anticancer agents, diuretics, anti-diabetic agents.
Abstract: Pyrazine is one of the important class of heterocyclic compounds that can be obtained naturally or synthesized chemically. Pyrazine ring has got importance in exhibiting various biological activities in association with other scaffolds like pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, oxazole, pyridine, piperidine and piperazine. Presence of pyrazine ring as a basic scaffold in various clinically used drugs exhibits its importance in drug design. In this review, attempt has been made to disclose various therapeutic applications of pyrazine derivatives reported during the last decade.
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Cite this article as:
Miniyar B. Pankaj, Murumkar R. Prashant, Patil S. Pallavi, Barmade A. Mahesh and Bothara G. Kailash, Unequivocal Role of Pyrazine Ring in Medicinally Important Compounds: A Review, Mini-Reviews in Medicinal Chemistry 2013; 13 (11) . https://dx.doi.org/10.2174/1389557511313110007
DOI https://dx.doi.org/10.2174/1389557511313110007 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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