Abstract
Several classes of compounds (thioureas, ureas, β-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.
Keywords: somatotropin release-inhibiting factor, Cortistatin, Nonpeptides, CNS disorders, TRPV1 receptor
Mini-Reviews in Medicinal Chemistry
Title: Somatostatin sst4 Ligands: Chemistry and Pharmacology
Volume: 7 Issue: 3
Author(s): A. Michael Crider and Ken A. Witt
Affiliation:
Keywords: somatotropin release-inhibiting factor, Cortistatin, Nonpeptides, CNS disorders, TRPV1 receptor
Abstract: Several classes of compounds (thioureas, ureas, β-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.
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Cite this article as:
Michael Crider A. and Witt A. Ken, Somatostatin sst4 Ligands: Chemistry and Pharmacology, Mini-Reviews in Medicinal Chemistry 2007; 7 (3) . https://dx.doi.org/10.2174/138955707780059880
DOI https://dx.doi.org/10.2174/138955707780059880 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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