Abstract
Cell penetrating peptides (CPPs) belong to the large family of membrane active peptides that comprises antimicrobial and viral fusion peptides with whom they share many properties. CPPs have been increasingly used to transport a wide range of molecules and nanoparticles inside cells. Despite their recognized potential transporting properties, their mode of action is far from being understood and has been a matter of debate. Penetratin, a widely used CPP is one of the first discovered CPPs, yet its mechanism of action remains obscure. Herein an overview on studies regarding cellular and liposomal uptake and the interaction with lipid model systems of CPPs and more particularly penetratin is provided. Special emphasis will be given to biophysical approaches to investigate penetratin/lipid interaction and subsequent lipid reorganization using lipid model systems.
Keywords: Cell penetrating peptides, penetratin, cellular internalization, liposome uptake, peptide/lipid interactions.
Current Protein & Peptide Science
Title:Is There Anybody in There? On The Mechanisms of Wall Crossing of Cell Penetrating Peptides
Volume: 13 Issue: 7
Author(s): Isabel D. Alves, Astrid Walrant, Cherine Bechara and Sandrine Sagan
Affiliation:
Keywords: Cell penetrating peptides, penetratin, cellular internalization, liposome uptake, peptide/lipid interactions.
Abstract: Cell penetrating peptides (CPPs) belong to the large family of membrane active peptides that comprises antimicrobial and viral fusion peptides with whom they share many properties. CPPs have been increasingly used to transport a wide range of molecules and nanoparticles inside cells. Despite their recognized potential transporting properties, their mode of action is far from being understood and has been a matter of debate. Penetratin, a widely used CPP is one of the first discovered CPPs, yet its mechanism of action remains obscure. Herein an overview on studies regarding cellular and liposomal uptake and the interaction with lipid model systems of CPPs and more particularly penetratin is provided. Special emphasis will be given to biophysical approaches to investigate penetratin/lipid interaction and subsequent lipid reorganization using lipid model systems.
Export Options
About this article
Cite this article as:
Alves D. Isabel, Walrant Astrid, Bechara Cherine and Sagan Sandrine, Is There Anybody in There? On The Mechanisms of Wall Crossing of Cell Penetrating Peptides, Current Protein & Peptide Science 2012; 13 (7) . https://dx.doi.org/10.2174/138920312804142174
DOI https://dx.doi.org/10.2174/138920312804142174 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hepatocyte Growth Factor Signaling in Cancer Metastasis
Current Signal Transduction Therapy Cathepsin L Induces Proangiogenic Changes in Human Omental Microvascular Endothelial Cells via Activation of the ERK1/2 Pathway
Current Cancer Drug Targets Bioanalytical and Biophysical Techniques for the Elucidation of the Mode of Action of Metal-Based Drugs
Current Topics in Medicinal Chemistry Vitamin D Analogs in Cutaneous Malignancies
Current Pharmaceutical Design PLK1 Inhibition Radiosensitizes Breast Cancer Cells, but Shows Low Efficacy as Monotherapy or in Combination with other Cytotoxic Drugs
Anti-Cancer Agents in Medicinal Chemistry Molecular Modelling Studies on Thiazole-Based α-Glucosidase Inhibitors Using Docking and CoMFA, CoMSIA and HQSAR
Current Drug Discovery Technologies BRCA1 as Target for Breast Cancer Prevention and Therapy
Anti-Cancer Agents in Medicinal Chemistry Proteomic Technologies and their Application for Ensuring Meat Quality, Safety and Authenticity
Current Proteomics Animal Models of Carcinogenesis in Inflamed Colorectum: Potential Use in Chemoprevention Study
Current Drug Targets Pharmacological Targeting of IDO-Mediated Tolerance for Treating Autoimmune Disease
Current Drug Metabolism Nanoparticles: Properties and Applications in Cancer Immunotherapy
Current Pharmaceutical Design Flavonoids: Prospective Drug Candidates
Mini-Reviews in Medicinal Chemistry Cancer/Testis Antigens Trigger Epithelial-Mesenchymal Transition and Genesis of Cancer Stem-Like Cells
Current Pharmaceutical Design Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets
Current Topics in Medicinal Chemistry Evolution of the Strategies for Screening and Identifying Human Tumor Antigens
Current Protein & Peptide Science Utility of Assessing Thiopurine S-methyltransferase Polymorphisms Before Azathioprine Therapy
Current Drug Metabolism Lipid-Based Nanoparticulate Systems for the Delivery of Anti-Cancer Drug Cocktails: Implications on Pharmacokinetics and Drug Toxicities
Current Drug Metabolism High-Performance Liquid Chromatographic Enantioseparation of Atropisomeric Biphenyls on Seven Chiral Stationary Phases
Current Organic Chemistry Recent Development of Copolymeric Nano-Drug Delivery System for Paclitaxel
Anti-Cancer Agents in Medicinal Chemistry Emergence of Functionalized Nanomedicines in Cancer Chemotherapy: Recent Advancements, Current Challenges and Toxicity Considerations
Recent Patents on Nanomedicine