Abstract
Many important clinical questions concerning primary Sjogren’s syndrome (pSS) remain, that can only be adequately addressed by prospective cohorts. Thus, a better knowledge of the clinical outcome, the course of disease activity and the risk factors of lymphoma requires the setting up of cohorts with biobanks. The homogeneous collection of clinical data, disease activity, patient-related outcome, and biological samples, including DNA, RNA and serum, is definitively mandatory to determine new biological prognostic factors and identify disease activity markers. Three large prospective cohorts have already started to enroll patients with pSS. This will be highly invaluable for scientists and clinicians to gain a better insight into the pathogenesis of pSS, as well as to identify prognostic markers and new therapeutic targets.
Keywords: Sjogren’s syndrome, prospective, cohort, disease activity, marker, clinical outcome, pathogenesis, therapeutic targets, clinical data, dryness symptoms, clinical disease, physical fatigue, prognostic factors, Sjogren’s International Collaborative Clinical Alliance (SICCA), clinical data.
Current Pharmaceutical Biotechnology
Title:Primary Sjogren’s Syndrome: Time for Prospective Cohorts
Volume: 13 Issue: 10
Author(s): Jacques-Eric Gottenberg and Xavier Mariette
Affiliation:
Keywords: Sjogren’s syndrome, prospective, cohort, disease activity, marker, clinical outcome, pathogenesis, therapeutic targets, clinical data, dryness symptoms, clinical disease, physical fatigue, prognostic factors, Sjogren’s International Collaborative Clinical Alliance (SICCA), clinical data.
Abstract: Many important clinical questions concerning primary Sjogren’s syndrome (pSS) remain, that can only be adequately addressed by prospective cohorts. Thus, a better knowledge of the clinical outcome, the course of disease activity and the risk factors of lymphoma requires the setting up of cohorts with biobanks. The homogeneous collection of clinical data, disease activity, patient-related outcome, and biological samples, including DNA, RNA and serum, is definitively mandatory to determine new biological prognostic factors and identify disease activity markers. Three large prospective cohorts have already started to enroll patients with pSS. This will be highly invaluable for scientists and clinicians to gain a better insight into the pathogenesis of pSS, as well as to identify prognostic markers and new therapeutic targets.
Export Options
About this article
Cite this article as:
Gottenberg Jacques-Eric and Mariette Xavier, Primary Sjogren’s Syndrome: Time for Prospective Cohorts, Current Pharmaceutical Biotechnology 2012; 13 (10) . https://dx.doi.org/10.2174/138920112802273128
DOI https://dx.doi.org/10.2174/138920112802273128 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
Latest Advancements in Biotherapeutics
The scope of this thematic issue is to comprehensively explore the rapidly evolving landscape of biotherapeutics, emphasizing breakthroughs in precision medicine. Encompassing diverse therapeutic modalities, the issue will delve into the latest developments in monoclonal antibodies, CRISPR/Cas gene editing, CAR-T cell therapies, and innovative drug delivery systems, such as nanoparticle-based ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Proprietary Topical Preparation Containing EGCG-Stearate and Glycerin with Inhibitory Effects on Herpes Simplex Virus: Case Study
Inflammation & Allergy - Drug Targets (Discontinued) The Arrestin Fold: Variations on a Theme
Current Genomics Prodrugs and Endogenous Transporters: Are They Suitable Tools for Drug Targeting into the Central Nervous System?
Current Pharmaceutical Design Membrane Bioreactors in Food, Pharmaceutical and Biofuel Applications: State of the Art, Progresses and Perspectives
Current Organic Chemistry Synthesis of pyridyl benzimidazoles encompassing 4-thiazolidinone derivatives as potential antimicrobial agents
Letters in Drug Design & Discovery Effects and Mechanisms of Medicinal Plants on Healing Scars: A Systematic Review
Current Traditional Medicine Insights into the Regulation of Renal Hemodynamic Function in Diabetic Mellitus
Current Diabetes Reviews Monoclonal Antibodies: A Review
Current Clinical Pharmacology Impact of HLA Haplotype on the Response to Antipsychotic Treatment of Schizophrenia
Current Pharmacogenomics Limonin, A Citrus Limonoid, had no Apparent Effect on Cognitive Dysfunction in Mice with Chronic Cerebral Hypoperfusion
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Erythropoietin in Cancer: An Update
Current Molecular Medicine Targeting Stenosis with Nucleotide-Hydrolyzing Enzymes
Current Pharmaceutical Biotechnology Biochemical Markers in CSF of ALS Patients
Current Medicinal Chemistry Flavonoids: The Innocuous Agents Offering Protection against Alzheimer’s Disease Through Modulation of Proinflammatory and Apoptotic Pathways
Current Topics in Medicinal Chemistry Marine Bioactive Peptides as Potential Antioxidants
Current Protein & Peptide Science Melatonin, Immune Function and Cancer
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Dengue: Recent Advances in Biology and Current Status of Translational Research
Current Molecular Medicine Cutaneous Autoimmune Phenomena of the Anti-TNFa Biosimilars. Casebased Review
Current Rheumatology Reviews Modulation of Anxiety Behavior by Intranasally Administered Vaccinia Virus Complement Control Protein and Curcumin in a Mouse Model of Alzheimers Disease
Current Alzheimer Research Postprandial Lipaemia, Haemostasis, Inflammatory Response and other Emerging Risk Factors for Cardiovascular Disease: The Influence of Fatty Meals
Current Nutrition & Food Science