Abstract
In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given the viability of the parenchyma. In particular, a chain of microcirculatory events will be described which - after specific endothelial activation by growth factors – enhances capillary and microcirculatory vessel formation, Backward signalling is introduced as potential mechanism to induce collateral growth, recruiting pre-existent macrovessel networks for blood supply to the increased microcirculatory cross sectional area. Potential signal cascades will be discussed.
Keywords: Angiogenesis, arteriogenesis, vasculogenesis, VEGF, eNOS, endothelial progenitor cells, vessel maturation, inflammation
Current Pharmaceutical Biotechnology
Title: The Vascular Compartments of Neovascularization: Spotlight on the Microcirculation
Volume: 8 Issue: 1
Author(s): Christian Kupatt
Affiliation:
Keywords: Angiogenesis, arteriogenesis, vasculogenesis, VEGF, eNOS, endothelial progenitor cells, vessel maturation, inflammation
Abstract: In this review, the compartments of the vasculature will be discussed with respect to their potential contribution to the build-up of a differentiated and functionally meaningful vessel system. Chronic ischemia of muscle tissue results in microvessel rarification, which represents a potential therapeutic target, given the viability of the parenchyma. In particular, a chain of microcirculatory events will be described which - after specific endothelial activation by growth factors – enhances capillary and microcirculatory vessel formation, Backward signalling is introduced as potential mechanism to induce collateral growth, recruiting pre-existent macrovessel networks for blood supply to the increased microcirculatory cross sectional area. Potential signal cascades will be discussed.
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Cite this article as:
Kupatt Christian, The Vascular Compartments of Neovascularization: Spotlight on the Microcirculation, Current Pharmaceutical Biotechnology 2007; 8 (1) . https://dx.doi.org/10.2174/138920107779941390
DOI https://dx.doi.org/10.2174/138920107779941390 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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