Abstract
BK channels are large conductance calcium-activated potassium channels that are found in many tissues, including excitable cells such as myocytes and neurons. The high conductance and dependence on calcium of BK channels suggests that modulation of these channels may have a pronounced effect on tissues in which they are expressed. Within the past four years, a variety of small molecules and natural product-derived modulators of BK channels have been described. This review will focus on compounds which are openers and blockers of BK channels and their therapeutic potential, with introductory sections covering the biophysics, pharmacology and molecular biology of BK channels.
Current Pharmaceutical Design
Title:Modulators of Large-Conductance Calcium-Activated Potassium (BK) Channels as Potential Therapeutic Targets
Volume: 2 Issue: 4
Author(s): John E. Starrett Jr.*, Steven I. Dworetzky and Valentin K. Gribkoff
Affiliation:
- Division of Central Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, 5 Research Parkway, Wallingford, USA
Abstract: BK channels are large conductance calcium-activated potassium channels that are found in many tissues, including excitable cells such as myocytes and neurons. The high conductance and dependence on calcium of BK channels suggests that modulation of these channels may have a pronounced effect on tissues in which they are expressed. Within the past four years, a variety of small molecules and natural product-derived modulators of BK channels have been described. This review will focus on compounds which are openers and blockers of BK channels and their therapeutic potential, with introductory sections covering the biophysics, pharmacology and molecular biology of BK channels.
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Cite this article as:
Starrett Jr. John E.*, Dworetzky Steven I. and Gribkoff Valentin K., Modulators of Large-Conductance Calcium-Activated Potassium (BK) Channels as Potential Therapeutic Targets, Current Pharmaceutical Design 1996; 2 (4) . https://dx.doi.org/10.2174/1381612802666220926184514
DOI https://dx.doi.org/10.2174/1381612802666220926184514 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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