Abstract
Tolfenamic acid is one of the conventional non-steroidal anti-inflammatory drugs (NSAIDs) commonly used for the treatment of inflammation, migraines and pain. There has been a growing body of experimental evidence that tolfenamic acid possesses anti-cancer activity. However, in order to develop a therapeutic strategy using tolfenamic acid for the treatment of cancer, further research is required to highlight reliable cellular and molecular mechanisms of anti-cancer properties. Tolfenamic acid has been shown to alter the expression of several genes that represent cancer hallmarks including apoptosis, growth arrest, angiogenesis and metastasis. Recently, a couple of research groups including ours reported that tolfenamic acid targets multiple oncogenic or tumor suppressive signaling pathways in various types of cancer models. Here, we highlight multiple molecular targets responsible for the anti-cancer mechanism of tolfenamic acid and the benefits of combinational use of this drug with other anti-cancer drugs.
Keywords: Angiogenesis, apoptosis, growth arrest, mechanism, metastasis, tolfenamic acid.
Current Medicinal Chemistry
Title:Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review
Volume: 25 Issue: 14
Author(s): David Feldman, Elizabeth Leahy and Seong-Ho Lee *
Affiliation:
- Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742,United States
Keywords: Angiogenesis, apoptosis, growth arrest, mechanism, metastasis, tolfenamic acid.
Abstract: Tolfenamic acid is one of the conventional non-steroidal anti-inflammatory drugs (NSAIDs) commonly used for the treatment of inflammation, migraines and pain. There has been a growing body of experimental evidence that tolfenamic acid possesses anti-cancer activity. However, in order to develop a therapeutic strategy using tolfenamic acid for the treatment of cancer, further research is required to highlight reliable cellular and molecular mechanisms of anti-cancer properties. Tolfenamic acid has been shown to alter the expression of several genes that represent cancer hallmarks including apoptosis, growth arrest, angiogenesis and metastasis. Recently, a couple of research groups including ours reported that tolfenamic acid targets multiple oncogenic or tumor suppressive signaling pathways in various types of cancer models. Here, we highlight multiple molecular targets responsible for the anti-cancer mechanism of tolfenamic acid and the benefits of combinational use of this drug with other anti-cancer drugs.
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Cite this article as:
Feldman David , Leahy Elizabeth and Lee Seong-Ho *, Chemopreventive Properties of Tolfenamic Acid: A Mechanistic Review, Current Medicinal Chemistry 2018; 25 (14) . https://dx.doi.org/10.2174/0929867324666170414155107
DOI https://dx.doi.org/10.2174/0929867324666170414155107 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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