Abstract
This article comments on the role of the most important biochemical markers that are already applied in clinical practice or are still under research, in Acute Coronary Syndromes (ACS). Cardiac troponin (cTn) is established as the ‘gold standard’ in the diagnosis of ACS. C-reactive protein (CRP) and especially high-sensitivity CRP (hs-CRP) are considered to be the most useful inflammatory markers for clinical practice in the setting of acute coronary syndrome. Brain-type natriuretic peptide (BNP) and the amino terminal fragment of the prohormone BNP (NT-proBNP) appear to provide prognostic information in individuals admitted for acute coronary syndromes. Microalbuminuria in nondiabetics appears to be a signal from the kidney that the vasculature, particularly the endothelium, is not functioning properly. Increased plasma levels of cystatin C, neopterin, myeloperoxidase, and pregnancy associated protein are associated with adverse cardiovascular outcomes, cardiovascular and noncardiovascular death, and possibly cerebrovascular disease. Furthermore, recent evidence suggests that serum levels of CD40-CD40L pathway exert important roles in progression, and outcome of acute coronary syndrome. In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS.
Keywords: Acute coronary syndromes, Troponin, Biomarkers, Inflammation
Current Medicinal Chemistry
Title: New Biochemical Markers in Acute Coronary Syndromes
Volume: 15 Issue: 13
Author(s): Dimitris Tousoulis, Anna-Maria Kampoli, Elli Stefanadi, Charalambos Antoniades, Gerasimos Siasos, Athanasios G. Papavassiliou and Christodoulos Stefanadis
Affiliation:
Keywords: Acute coronary syndromes, Troponin, Biomarkers, Inflammation
Abstract: This article comments on the role of the most important biochemical markers that are already applied in clinical practice or are still under research, in Acute Coronary Syndromes (ACS). Cardiac troponin (cTn) is established as the ‘gold standard’ in the diagnosis of ACS. C-reactive protein (CRP) and especially high-sensitivity CRP (hs-CRP) are considered to be the most useful inflammatory markers for clinical practice in the setting of acute coronary syndrome. Brain-type natriuretic peptide (BNP) and the amino terminal fragment of the prohormone BNP (NT-proBNP) appear to provide prognostic information in individuals admitted for acute coronary syndromes. Microalbuminuria in nondiabetics appears to be a signal from the kidney that the vasculature, particularly the endothelium, is not functioning properly. Increased plasma levels of cystatin C, neopterin, myeloperoxidase, and pregnancy associated protein are associated with adverse cardiovascular outcomes, cardiovascular and noncardiovascular death, and possibly cerebrovascular disease. Furthermore, recent evidence suggests that serum levels of CD40-CD40L pathway exert important roles in progression, and outcome of acute coronary syndrome. In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS.
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Tousoulis Dimitris, Kampoli Anna-Maria, Stefanadi Elli, Antoniades Charalambos, Siasos Gerasimos, Papavassiliou G. Athanasios and Stefanadis Christodoulos, New Biochemical Markers in Acute Coronary Syndromes, Current Medicinal Chemistry 2008; 15 (13) . https://dx.doi.org/10.2174/092986708784534965
DOI https://dx.doi.org/10.2174/092986708784534965 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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