Synthesis of a Shark Repellent Peptide Toxin, Pardaxin (16-33) on a Highly Flexible Polymer Support: Clpser

G.   S. Vinod   Kumar; S.      Leena; K.   Santhosh   Kumar

Abstract

A high swelling resin, CLPSER has been developed and utilized for the solid phase synthesis of Pardaxin, which is an 18-residue peptide. The resin was characterized by gel phase 13C NMR, IR and SEM. The utility of the new polymer support in polypeptide synthesis was further established by the comparative synthesis of pardaxin with commercially available Merrifield resin. The MALDI TOF MS, amino acid analysis and the HPLC revealed the superior quality of CLPSER.

Keywords: clpser support, polymerization, swelling, solid phase peptide synthesis

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Protein & Peptide Letters

Title: Synthesis of a Shark Repellent Peptide Toxin, Pardaxin (16-33) on a Highly Flexible Polymer Support: Clpser

Volume: 11 Issue: 6

Author(s): G. S. Vinod Kumar, S. Leena and K. Santhosh Kumar

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Keywords: clpser support, polymerization, swelling, solid phase peptide synthesis

Abstract: A high swelling resin, CLPSER has been developed and utilized for the solid phase synthesis of Pardaxin, which is an 18-residue peptide. The resin was characterized by gel phase 13C NMR, IR and SEM. The utility of the new polymer support in polypeptide synthesis was further established by the comparative synthesis of pardaxin with commercially available Merrifield resin. The MALDI TOF MS, amino acid analysis and the HPLC revealed the superior quality of CLPSER.

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Kumar S. Vinod G., Leena S. and Kumar Santhosh K., Synthesis of a Shark Repellent Peptide Toxin, Pardaxin (16-33) on a Highly Flexible Polymer Support: Clpser, Protein & Peptide Letters 2004; 11 (6) . https://dx.doi.org/10.2174/0929866043406175