Abstract
Background: An open-label, exploratory study has been conducted to investigate the efficacy of BDNF Essentials® for cognitive function and neurological health.
Methods: Twenty healthy adults ≥45 years of age, with a score ≥24 on the Mini-Mental State Examination (MMSE-2) and self-reported memory complaints were supplemented with BDNF Essentials ® for 84 days. Computerized Mental Performance Assessment System (COMPASS) tests for memory, attention, and processing speed were conducted, and change in plasma brain-derived neurotrophic factor (BDNF), Profile of Mood States (POMS), the Healthy People Sleep Quality Index (HPSQI), perceived stress scale (PSS), and salivary cortisol, interleukin (IL)-6, and tumour necrosis factor-α (TNF-α) were assessed at baseline and days 28, 56, and 84.
Results: Supplementation with BDNF Essentials® significantly increased COMPASS tests for memory, attention, and processing speed (all p < 0.05). Salivary cortisol was found to be significantly decreased at days 56 and 84 (p < 0.05), and IL-6 decreased at day 84 (P > 0.05). A reduction in depression-dejection at day 56 and in confusion-bewilderment at day 84, and an improvement in sleep satisfaction at day 56 (all p < 0.05) were reported.
Conclusion: BDNF Essentials® improved reaction time in measures of working memory, episodic memory, and attention, reduced biomarkers of stress and inflammation, and improved mood and sleep. BDNF Essentials® has been found to be safe and well-tolerated in adults with self-reported memory complaints.
Keywords: Cognition, BDNF, stress, inflammation, nutraceutical, dietary supplement.
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