Enhancing Gene Therapy through Ultradeformable Vesicles for Efficient siRNA Delivery

Title:Enhancing Gene Therapy through Ultradeformable Vesicles for Efficient siRNA Delivery

Volume: 12

Author(s): Chintan Aundhia*, Nirmal Shah, Chitrali Talele, Aarti Zanwar, Mamta Kumari and Sapana Patil

Affiliation:

• Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia, Vadodara, 391760, Gujarat, India

Keywords: Ultradeformable vesicles, siRNA delivery, Gene therapy, Nanocarriers, Drug delivery systems, Lipid-based vesicle

Abstract: Gene therapy is a revolutionary approach aimed at treating various diseases by manipulating the expression of specific genes. The composition and formulation of ultra-deformable vesicles play a crucial role in determining their properties and performance as siRNA delivery vectors. In the development of ultra-deformable vesicles for siRNA delivery, careful lipid selection and optimization are crucial for achieving desirable vesicle characteristics and efficient siRNA encapsulation and delivery. The stratum corneum acts as a protective barrier, limiting the penetration of molecules, including siRNA, into the deeper layers of the skin. Ultradeformable vesicles offer a promising solution to overcome this barrier and facilitate efficient siRNA delivery to target cells in the skin. The stratum corneum, the outermost layer of the skin, acts as a significant barrier to the penetration of siRNA.These engineering approaches enable the production of uniform and well-defined vesicles with enhanced deformability and improved siRNA encapsulation efficiency. Looking ahead, advancements in ultra-deformable vesicle design and optimization, along with continued exploration of combination strategies and regulatory frameworks, will further drive the field of ultra-deformable vesicle-based siRNA delivery.

Cite this article as:

Aundhia Chintan*, Shah Nirmal, Talele Chitrali, Zanwar Aarti, Kumari Mamta and Patil Sapana, Enhancing Gene Therapy through Ultradeformable Vesicles for Efficient siRNA Delivery, Pharmaceutical Nanotechnology 2024; 12 () . https://dx.doi.org/10.2174/0122117385271654231215064542