Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers

Title:Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers

Volume: 24

Author(s): Verma Abhinav, Rishabh Mittal, Mathiyazhagan Navaneethakannan, Ahirwar Sonu Singh, Mukherjee Sukhes and Kotnis Ashwin*

Affiliation:

• Department of Biochemistry, All India Institute of Medical Sciences Bhopal, Saket Nagar, Bhopal, Madhya Pradesh, India

Keywords: NAFLD, MAFLD, NASH, Insulin resistance, Dyslipidemia, Steatosis TyG index, RNA Splicing, Metabolic Derangement, Thrombospondin, Cytokeratin-18

Abstract: Non-alcoholic fatty liver disease is a globally prevalent disorder that can rapidly progress if not detected early. Currently, no accepted markers exist for early diagnosis and prognosis of NAFLD. This review describes derangement in major metabolic pathways of lipid, carbohydrate, and amino acids in NAFLD. It suggests that measuring levels of thrombospondin, TyG index, asymmetric dimethylarginine, LAL-A, GLP-1, FGF-21, and GSG index are potential markers for early diagnosis of NAFLD. A single marker may not indicate early NAFLD, and further large-scale studies on correlating levels of Thrombospondin-2, triglyceride-glucose index, and FGF-21 with NAFLD are warranted.

Cite this article as:

Abhinav Verma, Mittal Rishabh, Navaneethakannan Mathiyazhagan, Singh Sonu Ahirwar, Sukhes Mukherjee and Ashwin Kotnis*, Metabolic Derangement in Non-Alcoholic Fatty Liver Disease: Opportunities for Early Diagnostic and Prognostic Markers, Current Molecular Medicine 2024; 24 () . https://dx.doi.org/10.2174/0115665240269082240213115711