Association of MiRNA and Bone Tumors: Future Therapeutic Inroads

Title:Association of MiRNA and Bone Tumors: Future Therapeutic Inroads

Volume: 31

Author(s): Rashid Al-Shibli, Mohammed AlSuleimani, Ibrahim Ahmed, Abdullah Al Lawati and Srijit Das*

Affiliation:

• Department of Human & Clinical Anatomy, Sultan Qaboos University, Muscat123, Oman

Keywords: Bone, tumors, miRNAs, pathways, therapeutic agents.

Abstract: Small endogenous non-coding RNA molecules known as micro-ribonucleic acids (miRNAs) control post-transcriptional gene regulation. A change in miRNA expression is related to various diseases, including bone tumors. Benign bone tumors are categorized based on matrix production and predominant cell type. Osteochondromas and giant cell tumors are among the most common bone tumors. Interestingly, miRNAs can function as either tumor suppressor genes or oncogenes, thereby determining the fate of a tumor. In the present review, we discuss various bone tumors with regard to their prognosis, pathogenesis, and diagnosis. The association between miRNAs and bone tumors, such as osteosarcoma, Ewing’s sarcoma, chondrosarcoma, and giant-cell tumors, is also discussed. Moreover, miRNA may play an important role in tumor proliferation, growth, and metastasis. Knowledge of the dysregulation, amplification, and deletion of miRNA can be beneficial for the treatment of various bone cancers. The miRNAs could be beneficial for prognosis, treatment, future drug design, and treatment of resistant cases of bone cancer.

Cite this article as:

Al-Shibli Rashid, AlSuleimani Mohammed, Ahmed Ibrahim, Lawati Al Abdullah and Das Srijit*, Association of MiRNA and Bone Tumors: Future Therapeutic Inroads, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0109298673284932231226110754