Aims and objectives
Gadolinium (Gd) is highly beneficial in the field of radiology diagnostic.
It is well-known as gadolinium based contrast media (GBCA) for T1W MR Imaging [1-3].
Although it is toxic,
gadolinium can be safely administered to human bodies by binding Gd3+ to another agent,
known as chelate. Chelation process will change the properties of the gadolinium and allow classification based on their biochemical structure (linear or macrocyclic) and based on ionic charge (ionic or non-ionic) [3].
Macrocylic GBCA tends to bind with gadolinium longer than the...
Methods and materials
Twenty ddY mice,
female,
6-7 weeks old randomly divided into 4 treatment groups; Control,
GdCl3,
Gd-DTPA-BMA,
and Gd-DOTA (Table 1).
At the beginning of the study,
all mice were weighed and kept in a wooden shaved housing.
The temperature was maintained at room temperature and provided with free access to food and water.
Dorsal surface and abdominal surface of the animals were shaved at the beginning of the study,
and then re-shaved every week.
Body weight and clinical sign were observed daily.
Gadolinium (III) chloride...
Results
Study on gadolinium based contrast media (GBCA) are now rising since the discovery of NSF.
Numerous investigation showed that gadolinium has an important role in developing NSF-like skin lesion.
Skin lesion was appeared in Grant et al study on the relevance between gadolinium and NSF using naïve rats [4].Data obtained from our study indicated that gadolinium deposition doesn’t always cause clinical signs.
During the injection period,
scab formation in the skin could not be found and there are no significant changes in skin thickness of...
Conclusion
In this study,
we determine gadolinium deposition and its clinical effect in vivo using normal mice.
Despite high gadolinium deposition in several organs,
we observed no changes in the skin of the mice nor any other clinical sign rising related to the continuous administration of gadolinium solution.
Chelated gadolinium is safe to be administered for MR Imaging.
However,
chelate changes the structure of gadolinium and have more properties than free gadolinium [1,
3,
5,
6].
Previous studies showed that “free” gadolinium will rapidly bind with...
Personal information
Adhipatria Kartamihardja
Department of Radiology Diagnostic and Nuclear Medicine,
Gunma University,
Maebashi,
Japan;
Department of Nuclear Medicine and Molecular Imaging,
Universitas Padjajaran,
Bandung,
Indonesia;
[email protected]
Takahito Nakajima,
PhD
Department of Radiology Diagnostic and Nuclear Medicine,
Gunma University,
Maebashi,
Japan
Satomi Kameo,
PhD
Department of Public Health,
Gunma University,
Maebashi,
Japan
Yoshito Tsushima,
PhD
Department of Radiology Diagnostic and Nuclear Medicine,
Gunma University,
Maebashi,
Japan
References
1.Andrew Spencer,
Susan Wilson and Ernest Harpur.
Gadolonium chloride toxicity in the mouse.
Human & Experimental Toxicology 1998; 17: 633-637.
2.A.J.
Spencer,
S.A.
Wilson,
J.
Batchelor,
A.
Reid,
J.
Rees,
E.
Harpur.
Gadolinium Chloride Toxicity in the Rat.
Toxicologic Pathology 1997; 25: 245-255.
3.M.
Perazella.
Gadolinium-Contrast Toxicity in Patients with kidney Disease: Nephrotoxicity and Nephrogenic Systemic Fibrosis.
Current Drug Safety,
2008,
3,
67-75.
4.Grant D,
Johnsen H,
Juelsrud A,
Løvhaug D.
Effects of Gadolinium Contrast Agents in Naïve and Nephrectomized Rats: relevance to nephrogenic systemic...