From July 2020 to February 2022, 90 patients undergoing ^99mTc-3PRGD2.SPECT/CT examinations were divided into a study group and a control group according to a simple random number table, with 45 cases assigned to each group.

Inclusion criteria: (1) Patients undergoing ^99mTc-3PRGD2.SPECT/CT examination; (2) aged 18–70 years old; (3) clear consciousness and good understanding and communication abilities; and (4) patients or their families were aware of this study and signed a consent form.

Exclusion criteria: (1) Patients with speech communication disorders or cognitive dysfunction; (2) patients with mental system diseases; (3) patients with immune system diseases or systemic infectious diseases; and (4) patients with malignant tumors and cancer cell spread.

Control group: Routine nursing care was provided. (1) Before the examination, the importance, necessity, and basic knowledge of a ^99mTc-3PRGD2.SPECT/CT examination, including the purpose of the examination, relevant precautions, etc., were patiently explained to the patients to alleviate adverse emotions and guide them to report subjective feelings, patiently answer their questions, and ensure that the patients underwent the examination with a positive attitude; (2) During the examination, the vital signs and state of consciousness of the patients were closely monitored, and patients were given comfort by touching their limbs and other forms of reassurance to reduce tension and other psychological factors in the patient; and (3) After the examination, the patients were advised to drink more water to increase the urine volume and thus accelerate the efflux of radiopharmaceuticals, and we closely monitored whether the patient's hemogram was normal. Proper treatment was provided promptly if adverse reactions occurred.

Study group: On the basis of the control group, teach-back health education combined with structured psychological care and teach-back health education were adopted: (1) Information transmission: most patients had insufficient knowledge of ^99mTc-3PRGD2.SPECT/CT examination, including the fact that this examination mode involves radionuclide radiation, and most of them worried about their own symptoms and examination results. Thus, depression, anxiety, and fear were likely to occur. For this reason, the importance and purpose of the examination, relevant precautions, and cooperation skills during the examination were explained in detail to patients beforehand. (2) Effect evaluation: patients expressed the educational content in their own words. The patients were instructed to perform operation drills on the spot, and a thorough assessment of their understanding of the educational material was performed, based on which targeted adjustment and optimization were provided. The educational method was thus improved until the patients could effectively demonstrate their understanding of the educational content; and (3) Mastery was assessed by confirming that the patient could accurately and comprehensively repeat the relevant information regarding the ^99mTc-3PRGD2.SPECT/ CT examination.

Structured psychological nursing consists of the following components: (1) Active communication with patients is pursued to reduce alienation and bad mood using simple language to enhance understanding, showing a kind attitude, and talking at a peaceful speech rate to provide encouragement with active listening and establish a harmonious medical relationship. In this manner, patients are guided to report their inner feelings and alleviate bad mood by shifting attention, and their confidence is enhanced by actively describing to them successful cases, thus assisting them to adopt a good mentality; (2) Cognitive therapy is carried out in further psychological nursing, the staff collects and assesses the patient’s knowledge of ^99mTc-3PRGD2.SPECT/CT, understands their coping ability and psychological needs, points out their current improper understanding and coping behavior, promotes their correct understanding of ^99mTc-3PRGD2.SPECT/CT, and actively copes with psychological stress. This method can aggravate the psychological burden of patients to a certain extent, so the staff should first communicate with the family members, carry out effective psychological counseling and support, obtain the cooperation and support of the patient, and guide the family members to provide the patients with affectionate comfort and encouragement to improve their sense of security; and (3) The psychological state is consolidated through self-relaxation training; the patients are informed of the benefits of self-relaxation training ("breathing method"), including relieving psychological pressure and reducing the degree of pain, and are guided to repeat the various times.

Heart rate, diastolic blood pressure, and systolic blood pressure were assessed before, during, and after the examination in the two groups. The levels of depression and anxiety before and after intervention were determined according to the self-rating depression scale (SDS) and self-rating anxiety scale (SAS), respectively, with higher scores indicating more severe depression and anxiety. Statistics of cooperation: the evaluation of patients was scored with a maximum of 100 points: 90-100 points for complete cooperation; 70-89 points for basic cooperation, and less than 70 points for lack of cooperation. For this calculation, the following formula was used: examination cooperation = (complete cooperation + basic cooperation)/total number of cases × 100%. Statistical analysis of the intervention satisfaction as measured by the Newcastle Nursing Satisfaction Scale was performed. This scale rates patient satisfaction as very satisfied, generally satisfied, or dissatisfied, and satisfaction was calculated with the following formula: satisfaction = (generally satisfied + very satisfied)/total number of cases × 100%.

SPSS 22.0 was used to analyze the data. The data were expressed as mean ± SD, and the t test, enumeration data n (%), and χ² test were used in the analysis. P < 0.05 indicated that the difference was statistically significant.

The gender, age, education level, and other data of the participants in the study and control groups were similar and comparable (P > 0.05) (Table 1).

Before the examination, heart rate, diastolic blood pressure, and systolic blood pressure values in the two groups were not significantly different (P > 0.05). These measurement values were all higher in both groups after the examination compared to those measured before the examination. After the examination, these measurement values were lower in the study group than in the control group (P < 0.05) (Table 2).

Before the intervention, SDS (62.42 ± 6.01) and SAS (61.79 ± 5.45) scores in the study group were not significantly different from those in the control group (63.06 ± 5.64 and 62.29 ± 6.37) (P > 0.05). After the intervention, SDS (41.15 ± 4.51) and SAS (42.46 ± 5.19) scores in the study group were lower than those in the control group (46.05 ± 5.07 and 47.71 ± 5.62) (P < 0.05), as shown in Table 3.

The degree of cooperation during the examination was higher in the study group (97.78%) than in the control group (84.44%) (P < 0.05), as shown in Table 4.

Intervention satisfaction was higher in the study group (95.56%) than in the control group (82.22%) (P < 0.05), as shown in Table 5.

The results of this study showed that heart rate, diastolic blood pressure, and systolic blood pressure increased in both groups during and after the examination compared with those before the examination, but the levels of each index were lower in the study group than in the control group. The SDS and SAS scores were lower in the study group than in the control group after the intervention (P < 0.05), confirming that teach-back health education and structured psychological care can effectively alleviate depression and anxiety in ^99mTc-3PRGD2.SPECT/CT examinees; this is extremely important for maintaining a stable heart rate and blood pressure during the periprocedural period.

Traditional health education is transmitted unidirectionally from staff to intervention subjects, with insufficient interactivity, and in too uniformed and simplified a manner. Hence, it is difficult to stimulate the interest and enthusiasm of intervention subjects for learning, and the patient’s learning and mastery are not assessed in a timely manner after the intervention[12,13]. At the same time, an "amnesia curve" occurs during memory, and routine health education leads to difficulties in effectively mastering the health information provided. In contrast, teach-back health education adopts a two-way information exchange through the patient restatement and expression of the health education content; in this exchange, staff can assess the patient's mastery and provide subsequent targeted interventions to ensure that there is an improvement in the subjects’ enthusiasm and efficiency in learning. This occurs through the process of continuous strengthening and correction, which not only deepens their mastery of health knowledge, but also reduces the rate of amnesia[14,15]. In addition, psychological care also plays an important role in patients examined by SPECT-CT. Structured psychological nursing is a new clinical comprehensive nursing intervention model based on routine psychological nursing combined with other psychological nursing skills that allows nurses to implement interventions aimed at solving negative emotions and adverse psychological states of patients during diagnosis and treatment[16]. Compared with routine psychological nursing, structured psychological nursing can refer to the actual situation of patients analyzed for various parameters to meet their overall nursing needs as much as possible. Further, the patients and their families can participate in clinical nursing activities during the intervention[17].

The results of this study showed the examination cooperation was higher in the study group (97.78%) than in the control group (84.44%) (P < 0.05), confirming that teach-back health education and structured psychological care have a high application value in patients undergoing ^99mTc-3PRGD2.SPECT/CT examination. This can effectively relieve the depression and anxiety of patients and improve their cooperation during the procedure. Moreover, it is extremely important to maintain the stability of heart rate and blood pressure during the periprocedural period. The main reasons for this analysis were as follows: (1) teach-back health education is a patient-centered, flexible, and diverse form of education, and can be used to provide health education in appropriate forms. The nursing staff determines the patient's mastery of health knowledge through effective assessment and timeously detects deviations and cognitive deficiencies, so as to provide a targeted follow-up. At the same time, teach-back health education can strengthen the patient's memory, improve learning efficiency, reduce forgetfulness, and help patients to comprehensively master health education knowledge through repeated questioning, error correction, emphasis, and guidance, thus helping them realize the importance of the examination and encourage them to actively cooperate with it. Teach-back health education can continuously improve the nursing content through a two-way interactive information transmission and evaluation of the effects. It can also improve the quality of care, correct the patient's wrong notions, encourage them to actively cooperate with the diagnosis process and treatment, change their coping style, and help them to actively face and cooperate with the examination[18-20]. Psychological support was used as the basis of the cognitive intervention, and health education and stress coping skills were organically integrated. Before the intervention, a good relationship was first established with the patients, the characteristics of the patients were fully considered, and a psychological intervention program was targeted to alleviate fear, anxiety, tension, and other psychological factors in the patients, so that they could undergo the examination in a state of physical and mental relaxation and ensure safety.

The results of this study also showed that the rate of satisfaction with the intervention in the study group (95.56%) was higher than that in the control group (82.22%) (P < 0.05), thus indicating that teach-back health education combined with structured psychological care could also effectively improve the satisfaction of patients undergoing ^99mTc-3PRGD2.SPECT/CT examination by relieving negative emotions, maintaining a stable blood pressure and heart rate, and ensuring a smooth and stable examination process. At the same time, structured psychological care - based on psychological support combined with other types of psychological intervention techniques, and effectively combined with stress treatment, health education, and coping skills - helped nurses to patiently deal with patients' adverse emotions during treatment. This helped to improve patient satisfaction.

^99mTc-3PRGD2.SPECT/CT has many advantages, such as ease of operation, and plays an important role in clinical practice.

Effective care during the examination is critically needed.

We want to explore the value of teach-back health education combined with structured psychological nursing intervention.

Total 90 patients undergoing ^99mTc-3PRGD2.SPECT/CT examinations were divided into a study group and a control group according to a simple random number table.

The degree of cooperation and the satisfaction rate with the intervention was higher in the study group than in the control group.

Teach-back health education combined with structured psychological nursing can improve the satisfaction and cooperation of patients undergoing ^99mTc-3PRGD2.SPECT/CT examinations.

The sample size should be expanded, the uniformity and thoroughness of the experimental design could be improved, and more objective and effective evaluation criteria.