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Emerging tick-borne infections: rediscovered and better characterized, or truly ‘new’?

Published online by Cambridge University Press:  19 April 2005

S. R. TELFORD  and
H. K. GOETHERT
S. R. TELFORD
Affiliation:
Tufts University School of Veterinary Medicine, Division of Infectious Diseases, 200 Westboro Road, North Grafton, MA 01536, USA
H. K. GOETHERT
Affiliation:
Tufts University School of Veterinary Medicine, Division of Infectious Diseases, 200 Westboro Road, North Grafton, MA 01536, USA
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Abstract

The emergence of Lyme borreliosis as a public health burden within the last two decades has stimulated renewed interest in tick-borne infections. This attention towards ticks, coupled with advances in detection technologies, has promoted the recognition of diverse emergent or potentially emerging infections, such as monocytic and granulocytic ehrlichiosis, local variants of spotted fever group rickettsioses, WA-1 babesiosis, or a Lyme disease mimic (Masters' Disease). The distribution of pathogens associated with well-described tick-borne zoonoses such as human babesiosis due to Babesia microti or B. divergens seems wider than previously thought. Bartonellae, previously known to be maintained by fleas, lice or sandflies, have been detected within ticks. Purported ‘new’ agents, mainly identified by sequencing of PCR products and comparison with those sequences present in GenBank, are being increasingly reported from ticks. We briefly review the diversity of these infectious agents, identify aetiological enigmas that remain to be solved, and provide a reminder about ‘old friends’ that should not be forgotten in our pursuit of novelty. We suggest that newly recognised agents or tick/pathogen associations receive careful scrutiny before being declared as potential public health burdens.

Keywords

Tick-borne infectionsemerging diseasesbabesiosisrickettsiosisehrlichiosis
Type
Research Article
Information
Parasitology , Volume 129 , Issue S1 , October 2004 , pp. S301 - S327
Copyright
© 2004 Cambridge University Press

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References

REFERENCES

ACKERMANN, R., KRUGER, K. & ROGGENDORF, M. ( 1986). Spread of early-summer meningoencephalitis in the Federal Republic of Germany. Deutsche Medizinische Wochenschrift 111, 927–933.Google Scholar
ALEKSEEV, A., DUBININA, H., VAN DE POL, I. & SCHOULS, L. M. ( 2001). Identification of Ehrlichia spp. and Borrelia burgdorferi in Ixodes ticks in the Baltic region of Russia. Journal of Clinical Microbiology 39, 2237–2242.Google Scholar
ANDERSON, B. E., SIMS, K. G., OLSON, J. G., CHILDS, J. E., PIESMAN, J. F., HAPP, C. M., MAUPIN, G. O. & JOHNSON, B. J. ( 1993). Amblyomma americanum: a potential vector of human ehrlichiosis. American Journal of Tropical Medicine and Hygiene 49, 239–244.CrossRefGoogle Scholar
ANDERSON, J. F., MAGNARELLI, L. A., DONNER, C. S., SPIELMAN, A. & PIESMAN, J. ( 1979). Canine babesia new to North America. Science 204, 1431–1432.CrossRefGoogle Scholar
ANDERSON, J. F., MAGNARELLI, L. A. & SULZER, A. J. ( 1981). Raccoon babesiosis in Connecticut, USA: Babesia lotori sp. nov. Journal of Parasitology 67, 417–425.CrossRefGoogle Scholar
ANDREW, R., BONNIN, J. M. & WILLIAMS, S. ( 1946). Tick typhus in northern Queensland. Medical Journal of Australia 2, 253–258.Google Scholar
ANIGSTEIN, L. & ANIGSTEIN, D. ( 1975). A review of the evidence in retrospect for a rickettsial etiology in Bullis Fever. Texas Reports in Biology and Medicine 33, 201–211.Google Scholar
ANONYMOUS ( 1995 a). Arboviral disease – United States 1994. Morbidity and Mortality Weekly Report 44, 641–644.
ANONYMOUS ( 1995 b). Tick-borne encephalitis. Weekly Epidemiological Record 70, 120–122.
ANONYMOUS ( 1972). Pathogenic Mycoplasmas. Elsevier, Amsterdam.
ANTONOV, N. & NAISHTAT, A. ( 1937). Far eastern tick typhus – cases of tropical typhus in the Far East. Medizina Parazitologiya 6, 73–81.Google Scholar
ANTYKOVA, L. P. ( 1989). Epidemiology of tick-borne encephalitis in Leningrad. Trudy Instituta Imeni Pastera 65, 21–25.Google Scholar
ARMSTRONG, P. M., BRUNET, L. R., SPIELMAN, A. & TELFORD, S. R. ( 2001). Risk of Lyme disease: perceptions of residents of a Lone Star tick-infested community. Bulletin of the World Health Organization 79, 916–925.Google Scholar
ARMSTRONG, P. M., KATAVOLOS, P., CAPORALE, D. A., SMITH, R. P., SPIELMAN, A. & TELFORD, S. R. ( 1998). Diversity of Babesia infecting deer ticks (Ixodes dammini). American Journal of Tropical Medicine and Hygiene 58, 739–742.CrossRefGoogle Scholar
ARTSOB, H. ( 1989). Powassan encephalitis. In The Arboviruses: Epidemiology and Ecology, vol. IV (ed. Monath, T. P.), pp. 29–49. CRC Press, Boca Raton, USA.
ATTOUI, H., STIRLING, J. M., MUNDERLOH, U. G., BILLOIR, F., BROOKES, S. M., BURROUGHS, J. N., DE MICCO, P., MERTENS, P. P. & DELAMBALLERIE, X. ( 2001). Complete sequence characterization of the genome of the St. Croix River virus, a new orbivirus isolated from the cells of Ixodes scapularis. Journal of General Virology 82, 795–804.Google Scholar
BAJER, A., PAWELCZYK, A., BEHNKE, J. M., GILERT, F. S. & SINSKI, E. ( 2001). Factors affecting the community structure of haemoparasites in bank voles (Clethrionomys glareolus) from the Mazury Lake District region of Poland. Parasitology 122, 43–54.CrossRefGoogle Scholar
BAKKEN, J. S., KRUETH, J., TILDEN, R. L., DUMLER, J. S. & KRISTIANSEN, B. E. ( 1996 a). Serological evidence of human granulocytic ehrlichiosis in Norway. European Journal of Clinical Microbiology and Infectious Diseases 15, 829–832.Google Scholar
BAKKEN, J. S., KRUETH, J., WILSON-NORDSKOG, C., TILDEN, R. L., ASANOVICH, K. & DUMLER, J. S. ( 1996 b). Clinical and laboratory characteristics of human granulocytic ehrlichiosis. Journal of the American Medical Association 275, 199–205.Google Scholar
BANERJEE, K. ( 1986). Kyasanur forest disease. In The Arboviruses: Epidemiology and Ecology, Volume III (ed. Monath, T. P.), pp. 93–116. CRC Press, Boca Raton, USA.
BARBOUR, A. G. ( 1996). Does Lyme disease occur in the south?: a survey of emerging tick-borne infections in the region. American Journal of the Medical Sciences 311, 34–40.CrossRefGoogle Scholar
BEATI, L., PETER, O., BURGDORFER, W., AESCHLIMANN, A. & RAOULT, D. ( 1993). Confirmation that Rickettsia helvetica sp. nov. is a distinct species of the spotted fever group rickettsiae. International Journal of Systematic Bacteriology 43, 521–526.Google Scholar
BEATTIE, J. F., MICHELSON, M. L. & HOLMAN, P. J. ( 2002). Acute babesiosis caused by Babesia divergens in a resident of Kentucky. New England Journal of Medicine 347, 697–698.CrossRefGoogle Scholar
BELL, J. F., STEWART, S. J. & WIKEL, S. K. ( 1979). Resistance to tick-borne Francisella tularensis by tick-sensitized rabbits – allergic klendusity. American Journal of Tropical Medicine and Hygiene 28, 876–880.CrossRefGoogle Scholar
BELONGIA, E. A., REED, K. D., MITCHELL, P. D., KOLBERT, C. P., PERSING, D. H., GILL, J. S. & KAZMIERCZAK, J. J. ( 1997). Prevalence of granulocytic Ehrlichia infection among white-tailed deer in Wisconsin. Journal of Clinical Microbiology 35, 1465–1468.Google Scholar
BILLINGS, A. N., TELTOW, G., WEAVER, S. C. & WALKER, D. H. ( 1998 b). Molecular characterization of a novel Rickettsia species from Ixodes scapularis in Texas. Emerging Infectious Diseases 4, 305–309.Google Scholar
BILLINGS, A. N., YU, J., TEEL, P. D. & WALKER, D. H. ( 1998 a). Detection of a spotted fever group rickettsia in Amblyomma cajennense (Acari: Ixodidae) in south Texas. Journal of Medical Entomology 35, 474–478.Google Scholar
BJOERSDORFF, A., WITTESJO, B., BERGLUND, J., MASSUNG, R. F. & ELIASSON, I. ( 2002). Human granulocytic ehrlichiosis as a common cause of tick-associated fever in Southeast Sweden: Report from a prospective clinical study. Scandinavian Journal of Infectious Diseases 34, 187–191.CrossRefGoogle Scholar
BOWN, K. J., BEGON, M., BENNETT, M., WOLDEHIWET, Z. & OGDEN, N. H. ( 2003). Seasonal dynamics of Anaplasma phagocytophila in a rodent-tick (Ixodes trianguliceps) system, United Kingdom. Emerging Infectious Diseases 9, 63–70.CrossRefGoogle Scholar
BREDT, A. B., WEINSTEIN, W. M. & COHEN, S. ( 1981). Treatment of babesiosis in asplenic patients. Journal of the American Medical Association 245, 1938–1939.CrossRefGoogle Scholar
BREZINA, R., REHACEK, J., AC., P. & MAJERSKA, M. ( 1969). Two strains of Rickettsiae of Rocky Mountain Spotted Fever group recovered from Dermacentor marginatus ticks in Czechoslovakia. Acta Virologica 13, 142–145.Google Scholar
BROADHURST, L. E., KELLY, D. J., CHAN, C. T., SMOAK, B. L., BRUNDAGE, J. F., McCLAIN, J. B. & MILLER, R. N. ( 1998). Laboratory evaluation of a dot-blot enzyme immunoassay for serologic confirmation of illness due to Rickettsia conorii. American Journal of Tropical Medicine and Hygiene 58, 786–789.CrossRefGoogle Scholar
BRODIE, T. A., HOLMES, P. H. & URQUHART, G. M. ( 1988). Prophylactic use of long-acting tetracyclines against tick-borne fever (Cytoecetes phagocytophila) in sheep. Veterinary Record 122, 43–44.CrossRefGoogle Scholar
BROUQUI, P., HARLE, J. R., DELMONT, J., FRANCES, C., WEILLER, P. J. & RAOULT, D. ( 1997). African tick-bite fever – An imported spotless rickettsiosis. Archives of Internal Medicine 157, 119–124.CrossRefGoogle Scholar
BROUQUI, P., SANOGO, Y. O., CARUSO, G., MEROLA, F. & RAOULT, D. ( 2003). Candidatus Ehrlichia walkerii: A new Ehrlichia detected in Ixodes ricinus tick collected from asymptomatic humans in northern Italy. Annals of the New York Academy of Sciences 990, 134–140.CrossRefGoogle Scholar
BULLER, R. S., ARENS, M., HMIEL, S. P., PADDOCK, C. D., SUMNER, J. W., RIKIHISA, Y., UNVER, A., GAUDREAULT-KEENER, M., MANIAN, F. A., LIDDELL, A. M., SCHMULEWITZ, N. & STORCH, G. A. ( 1999). Ehrlichia ewingii, a newly recognized agent of human ehrlichiosis. New England Journal of Medicine 341, 148–155.CrossRefGoogle Scholar
BURGDORFER, W., AESCHLIMANN, A., PETER, O., HAYES, S. F. & PHILIP, R. N. ( 1979). Ixodes ricinus – vector of a hitherto undescribed spotted-fever group agent in Switzerland. Acta Tropica 36, 357–367.Google Scholar
BURGDORFER, W., HAYES, S. F. & MAVROS, A. J. ( 1981 a). Nonpathogenic rickettsiae in Dermacentor andersoni: a limiting factor for the distribution of Rickettsia rickettsii. In Rickettsiae and rickettsial diseases (ed. Burgdorfer, W. & Anacker, R. L.), pp. 585–594. Academic Press, New York.
BURGDORFER, W., HAYES, S. F., THOMAS, L. A. & LANCASTER, J. L. ( 1981 b). A new spotted fever group rickettsia from the Lone Star tick, Amblyomma americanum. In Rickettsiae and Rickettsial Diseases (ed. Burgdorfer, W. & Anacker, R. L.), pp. 595–599. Academic Press, New York.
BUSTAMANTE, M. E., VARELA, G. & ORTIZ-MARIOTTE, C. ( 1946). Estudios de fiebre manchada en Mexico. Revista de Instituto Salubria y Enfermedades Tropicale 7, 39–48.Google Scholar
CAMACHO, A. T., PALLAS, E., GESTAL, J., GUITIAN, F. J., OLMEDA, A. S., GOETHERT, H. K. & TELFORD, S. R. 3rd ( 2001). Infection of dogs in north-west Spain with a Babesia microti-like agent. The Veterinary Record 149, 552–555.CrossRefGoogle Scholar
CAO, W.-C., GAO, Y.-M., ZHANG, P.-H., ZHANG, X.-T., DAI, Q.-H., DUMLER, J. S., FANG, L.-Q. & YANG, H. ( 2000 a). Identification of Ehrlichia chaffeensis by nested PCR in ticks from southern China. Journal of Clinical Microbiology 38, 2778–2780.Google Scholar
CAO, W.-C., ZHAO, Q.-M., ZHANG, P.-H., DUMLER, J. S., ZHANG, X.-T., FANG, L.-Q. & YANG, H. ( 2000 b). Granulocytic ehrlichiae in Ixodes persulcatus ticks from an area in China where Lyme disease is endemic. Journal of Clinical Microbiology 38, 4208–4210.Google Scholar
CHANG, C. C., CHOMEL, B. B., KASTEN, R. W., ROMANO, V. & TIETZE, N. ( 2001). Molecular evidence of Bartonella spp. in questing adult Ixodes pacificus ticks in California. Journal of Clinical Microbiology 39, 1221–1226.Google Scholar
CHANG, C. C., HAYASHIDANI, H., PUSTERLA, N., KASTEN, R. W., MADIGAN, J. E. & CHOMEL, B. B. ( 2002). Investigation of Bartonella infection in ixodid ticks from California. Comparative Immunology Microbiology and Infectious Diseases 25, 229–236.CrossRefGoogle Scholar
CHASTEL, C. ( 1980). Arbovirus transmis par des tiques et associes a des oiseaux de mer: une revue generale. Medicine Tropicale 40, 535–548.Google Scholar
CHASTEL, C., MAIN, A. J., COUATARMANACH, A., LELAY, G., KNUDSON, D. L., QUILLIEN, M. C. & BEAUCORNU, J. C. ( 1984). Isolation of Eyach virus from Ixodes ricinus and I. ventalloi ticks in France. Archives of Virology 82, 161–171.Google Scholar
CHEN, S. M., DUMLER, J. S., BAKKEN, J. S. & WALKER, D. H. ( 1994). Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. Journal of Clinical Microbiology 32, 589–595.Google Scholar
CONOR, A. & BRUCH, A. ( 1910). Une fievre eruptive observee en Tunisie. Bulletin de Societe Pathologie Exotique 3, 492–496.Google Scholar
COSTERO, A. & GRAYSON, M. ( 1996). Experimental transmission of Powassan virus (Flaviviridae) by Ixodes scapularis ticks (Acari: Ixodidae). American Journal of Tropical Medicine and Hygiene 55, 536–546.CrossRefGoogle Scholar
DALTON, M. J., CLARKE, M. J., HOLMAN, R. C., KREBS, J. W., FISHBEIN, D. B. & OLSON, J. G. ( 1995). National surveillance for Rocky Mountain Spotted Fever 1981–1992: epidemiologic summary and evaluation of risk factors for fatal outcome. American Journal of Tropical Medicine and Hygiene 52, 405–413.CrossRefGoogle Scholar
DAWSON, J. E., STALLKNECHT, D. E., HOWERTH, E. W., WARNER, C., BIGGIE, K., DAVIDSON, W. R., LOCKHART, J. M., NETTLES, V. F., OLSON, J. G. & CHILDS, J. E. ( 1994). Susceptibility of white-tailed deer (Odocoileus virginianus) to infection with Ehrlichia chaffeensis, the etiologic agent of human ehrlichiosis. Journal of Clinical Microbiology 32, 2725–2728.Google Scholar
DE MARVAL, F. ( 1995). L'encephalite a tiques en suisse: epidemiologie et prevention. Medecin et Hygiene 53, 224–226.Google Scholar
DENNIS, D. T., INGLESBY, T. V., HENDERSON, D. A., BARTLETT, J. G., ASCHER, M. S., TZEN, E., FINE, A. D., FRIEDLANDER, A. M., HAUER, J., LAYTON, M., LILLIBRIDGE, S. R., McDADE, J. E., OSTERHOLM, M. T., O'TOOLE, T., PARKER, G., PERL, T. M., RUSSELL, P. K., TONAT, K. & THE WORKING GROUP ON CIVILIAN BIODEFENSE ( 2001). Tularemia as a biological weapon: medical and public health management. Journal of the American Medical Association 285, 2763–2773.CrossRefGoogle Scholar
DONNELLY, J. & PIERCE, M. A. ( 1975). Experiments on the transmission of Babesia divergens to cattle by the tick Ixodes ricinus. International Journal for Parasitology 5, 363–367.CrossRefGoogle Scholar
DUMLER, J. S. & BAKKEN, J. S. ( 1995). Ehrlichial diseases of humans: emerging tick-borne infections. Clinical Infectious Diseases 20, 1102–1110.CrossRefGoogle Scholar
DUMLER, J. S., BARBET, A. F., BEKKER, C. P., DASCH, G. A., PALMER, G. H., RAY, S. C., RIKIHISA, Y. & RURANGIRWA, F. R. ( 2001). Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and ‘HGE agent’ as subjective synonyms of Ehrlichia phagocytophila. International Journal of Systematic and Evolutionary Microbiology 51, 2145–2165.CrossRefGoogle Scholar
EBEL, G. D., SPIELMAN, A. & TELFORD, S. R. 3rd ( 2001). Phylogeny of North American Powassan virus. Journal of General Virology 82, 1657–1665.CrossRefGoogle Scholar
ENG, T. R., HARKESS, J. R., FISHBEIN, D. B., DAWSON, J. E., GREENE, C. N., REDUS, M. A. & SATALOWICH, F. T. ( 1990). Epidemiologic, clinical, and laboratory findings of human ehrlichiosis in the United States 1988. Journal of the American Medical Association 264, 2251–2258.CrossRefGoogle Scholar
ENIGK, K. & FRIEDHOFF, K. ( 1962). Babesia capreoli n. sp., beim Reh (Capreolus capreolus L.). Zentralblatt für Tropenmedizin und Parazitologie 13, 8–20.Google Scholar
EREEMEVA, M. E., BEATI, L., MAKAROVA, V. A., FETISOVA, N. F., TARASEVICH, I. V., BALAYEVA, N. M. & RAOULT, D. ( 1994). Astrakhan fever rickettsiae: antigenic and genotyping of isolates obtained from human and Rhipicephalus pumilio ticks. American Journal of Tropical Medicine and Hygiene 51, 697–706.CrossRefGoogle Scholar
ESKOW, E., RAO, R. V. S. & MORDECHAI, E. ( 2001). Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae – Evidence for a novel tick-borne disease complex. Archives of Neurology 58, 1357–1363.CrossRefGoogle Scholar
EVANS, A. S. ( 1976). Causation and disease – Henle-Koch postulates revisited. Yale Journal of Biology and Medicine 49, 175–195.Google Scholar
EWING, S. A., DAWSON, J. E., KOCAN, A. A., BARKER, R. W., WARNER, C. K., PANCIERA, R. J., FOX, J. C., KOCAN, K. M. & BLOUIN, E. F. ( 1995). Experimental transmission of Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) among white-tailed deer by Amblyomma americanum (Acari: Ixodidae). Journal of Medical Entomology 32, 368–374.CrossRefGoogle Scholar
EWING, S. A. & PHILIP, C. B. ( 1966). Ehrlichia-like rickettsiosis in dogs in Oklahoma and its relationship to Neorickettsia helminthoeca. American Journal of Veterinary Research 27, 67–69.Google Scholar
FAVOROV, M. O., KOSOY, M. Y., TSAREV, S. A., CHILDS, J. E. & MARGOLIS, H. S. ( 2000) Prevalence of antibody to hepatitis E virus among rodents in the United States. Journal of Infectious Diseases 181 (Feb), 449–455.CrossRefGoogle Scholar
FELDMAN, K. A., STILES-ENOS, D., JULIAN, K., MATYAS, B. T., TELFORD, S. R., CHU, M. C., PETERSON, L. R. & HAYES, E. B. ( 2003). Tularemia on Marthas Vineyard: seroprevalence and occupational risk. Emerging Infectious Diseases 9, 350–354.CrossRefGoogle Scholar
FINGERLE, V., GOODMAN, J. L., JOHNSON, R. C., KURTTI, T. J., MUNDERLOH, U. G. & WILSKE, B. ( 1997). Human granulocytic ehrlichiosis in southern Germany: increased seroprevalence in high-risk groups. Journal of Clinical Microbiology 35, 3244–3247.Google Scholar
FISHBEIN, D. B., KEMP, A., DAWSON, J. E., GREENE, N. R., REDUS, M. A. & FIELDS, D. H. ( 1989). Human ehrlichiosis: prospective active surveillance in febrile hospitalized patients. Journal of Infectious Diseases 160, 803–809.CrossRefGoogle Scholar
FOGGIE, A. ( 1951). Studies on the infectious agent of tick-borne fever in sheep. Journal of Pathology and Bacteriology 63, 1–15.CrossRefGoogle Scholar
FOGGIE, A. ( 1962). Studies on the tick pyaemia and tick-borne fever. Symposia of the Zoological Society of London 6, 51–60.Google Scholar
FOPPA, I. M., KRAUSE, P. J., SPIELMAN, A., GOETHERT, H., GERN, L., BRANDT, B. & TELFORD, S. R. ( 2002). Entomologic and serologic evidence of zoonotic transmission of Babesia microti in Switzerland. Emerging Infectious Diseases 8, 722–726.CrossRefGoogle Scholar
FOURNIER, P.-E., FUJITA, H., TAKADA, N. & RAOULT, D. ( 2002). Genetic identification of rickettsiae isolated from ticks in Japan. Journal of Clinical Microbiology 40, 2176–2181.CrossRefGoogle Scholar
FOURNIER, P.-E., GRUNNENBERER, F., JAULHAC, B., GASTINGER, G. & RAOULT, D. ( 2000). Evidence of Rickettsia helvetica infection in humans, eastern France. Emerging Infectious Diseases 6, 389–392.CrossRefGoogle Scholar
FRANCA, C. ( 1910). Sur la classification des piroplasmes et description des deux formes de ces parasites. Archives of the Royal Institute of Bacteriology Camara Pestana Lisbon, Portugal 3, 11–18.Google Scholar
FREDRICKS, D. N. & RELMAN, D. A. ( 1996). Sequence-based identification of microbial pathogens: A reconsideration of Kochs postulates. Clinical and Microbiological Reviews 9, 18–33.Google Scholar
GEAR, J. H. S. ( 1954). The rickettsial diseases of southern Africa. South African Journal of Clinical Science 5, 158–175.Google Scholar
GILL, V. & CUNHA, B. A. ( 1997). Tularemia pneumonia. Seminars in Respiratory Infections 12, 61–67.Google Scholar
GOETHERT, H. K. & TELFORD, S. R. 3rd ( 2003 a). Enzootic transmission of Babesia divergens in cottontail rabbits on Nantucket Island. American Journal of Tropical Medicine and Hygiene 69, 455–460.Google Scholar
GOETHERT, H. K. & TELFORD, S. R. 3rd ( 2003 b). What is Babesia microti? Parasitology 127, 301–309.Google Scholar
GOLDMAN, L., ROCKWELL, E. & RICHFIELD, D. F. ( 1952). Histopathological studies on the cutaneous reactions to the bites of various arthropods. American Journal of Tropical Medicine and Hygiene 1, 514–525.CrossRefGoogle Scholar
GOLDWASSER, R. A., STEIMAN, Y., KLINGBERG, W., SWARTZ, T. A. & KLINGBERG, M. A. ( 1974). The isolation of strains of rickettsiae of the spotted fever group in Israel and their differentiation from other members of the group by immunofluorescence methods. Scandinadvian Journal of Infectious Diseases 6, 53–62.CrossRefGoogle Scholar
GONGORA-BIACHI, R. A., ZAVALA-VELAZQUEZ, J., CASTRO-SANSORES, C. J. & GONZALEZ-MARTINEZ, P. ( 1999). First case of human ehrlichiosis in Mexico. Emerging Infectious Diseases 5, 481.CrossRefGoogle Scholar
GRAVES, S., DWYER, B. W., McCOLL, B. & McDADE, J. E. ( 1991). Flinders Island Spotted Fever: a newly recognised endemic focus of tick typhus in Bass Strait. Part 2. Serological investigations. Medical Journal of Australia 154, 99–104.Google Scholar
GRAVES, S. & STENOS, J. ( 2003). Rickettsia honei: a spotted fever group rickettsia on three continents. Annals of the New York Academy of Sciences 990, 62–66.CrossRefGoogle Scholar
GRAY, J., VON STEDINGK, L. V., GURTELSCHMID, M. & GRANSTROM, M. ( 2002). Transmission studies of Babesia microti in Ixodes ricinus ticks and gerbils. Journal of Clinical Microbiology 40, 1259–1263.CrossRefGoogle Scholar
GRESIKOVA, M. & CALISHER, C. H. ( 1989). Tickborne encephalitis. In The Arboviruses: Epidemiology and Ecology, Volume IV ( ed. Monath, T. P.), pp. 177–202. CRC Press, Boca Raton, USA.
GRETILLAT, S., MATTEI, X. & MARCHAND, B. ( 1981). Une rickettsiale nouvelle (Ehrlichiae) des leucocytes du sang dur rat de Gambie (Cricetomys gambianus) au Senegal: Cytoecetes kamtchoulii n.sp. Revue de Elevage et de Medecine Veterinaire des Pays Tropicaux 34, 391–396.Google Scholar
GROEN, J., KORAKA, P., NUR, Y. A., AVSIC-ZUPANC, T., GOESSENS, W. H., OTT, A. & OSTERHAUS, A. D. ( 2002). Serologic evidence of ehrlichiosis among humans and wild animals in the Netherlands. European Journal of Clinical Microbioogy and Infectious Diseases 21, 46–49.CrossRefGoogle Scholar
GUILLAUME, B., HEYMAN, P., LAFONTAINE, S., VANDENVELDE, C., DELMEE, M. & BIGAIGNON, G. ( 2002). Seroprevalence of human granulocytic ehrlichlosis infection in Belgium. European Journal of Clinical Microbiology and Infectious Diseases 21, 397–400.Google Scholar
HARDEN, V. ( 1990). Rocky Mountain Spotted Fever: History of a Twentieth Century Disease. Johns Hopkins University Press, Baltimore, MD.
HAYFLICK, L. ( 1969). The Mycoplasmatales and the L-phase of Bacteria. Appleton Century Crofts, New York.CrossRef
HEALING, T. D. ( 1981). Infections with blood parasites in the small British rodents Apodemus sylvaticus, Clethrionomys glareolus and Microtus agrestis. Parasitology 83, 179–189.CrossRefGoogle Scholar
HEALY, G. R., WALZER, P. D. & SULZER, A. ( 1976). A case of asymptomatic babesiosis in Georgia. American Journal of Tropical Medicine and Hygiene 25, 376–378.CrossRefGoogle Scholar
HEO, E. J., PARK, J. H., KOO, J. R., PARK, M. S., PARK, M. Y., DUMLER, J. S. & CHAE, J. S. ( 2002). Serologic and molecular detection of Ehrlichia chaffeensis and Anaplasma phagocytophila (human granulocytic ehrlichiosis agent) in Korean patients. Journal of Clinical Microbiology 40, 3082–3085.CrossRefGoogle Scholar
HEPPNER, D. G., WONGSRICHANALAI, C., WALSH, D. S., McDANIEL, P., EAMSILA, C., HANSON, B. & PAXTON, H. ( 1997). Human ehrlichiosis in Thailand. Lancet 350, 785–786.CrossRefGoogle Scholar
HERWALDT, B. L., CACCIO, S., GHERLINZONI, F., ASPOCK, H., SLEMENDA, S. B., PICCALUGA, P., MARTINELLI, G., EDELHOFER, R., HOLLEUSTEIN, U., POLLETTI, G., PAMPIGLIONE, S., LOSCHENBERGER, K., TURA, S. & PIENIAZEK, N. J. ( 2003). Molecular characterization of a non-Babesia divergens organism causing babesiosis in Europe. Emerging Infectious Diseases 9, 942–948.CrossRefGoogle Scholar
HERWALDT, B. L., KJEMTRUP, A. M., CONRAD, P. A., BARNES, R. C., WILSON, M., McCARTHY, M. G., SAYERS, M. H. & EBERHARD, M. L. ( 1997). Transfusion-transmitted babesiosis in Washington State: first reported case caused by a WA1-type parasite. Journal of Infectious Diseases 175, 1259–1262.CrossRefGoogle Scholar
HERWALDT, B. L., PERSING, D. H., PRECIGOUT, E. A., GOFF, W. L., MATHIESEN, D. A., TAYLOR, P. W., EBERHARD, M. L. & GORENFLOT, A. F. ( 1996). A fatal case of babesiosis in Missouri: Identification of another piroplasm that infects humans. Annals of Internal Medicine 124, 643–650.CrossRefGoogle Scholar
HOARE, C. A. ( 1980). Comparative aspects of human babesiosis. Transactions of the Royal Society of Tropical Medicine and Hygiene 74, 143–148.CrossRefGoogle Scholar
HOFMEISTER, E. K., KOLBERT, C. P., ABDULKARIM, A. S., MAGERA, J. M. H., HOPKINS, M. K., UHL, J. R., AMBYAYE, A., TELFORD, S. R., COCKERILL, F. R. & PERSING, D. H. ( 1998). Cosegregation of a novel Bartonella species with Borrelia burgdorferi and Babesia microti in Peromyscus leucopus. Journal of Infectious Diseases 177, 409–416.CrossRefGoogle Scholar
HOPLA, C. ( 1974). The ecology of tularemia. Advances in Veterinary Sciences and Comparative Medicine 18, 25–53.Google Scholar
HUBALEK, Z., CALISHER, C. H. & MITTERMAYER, T. ( 1987). A new subtype (“Brezova”) of Tribec orbivirus (Kemerovo group) isolated from Ixodes ricinus males in Czechoslovakia. Acta Virologica 31, 91–92.Google Scholar
HUNFELD, K. P., LAMBERT, A., KAMPEN, H., ALBERT, S., EPE, C., BRADE, V. & TENTER, A. M. ( 2002). Seroprevalence of Babesia infections in humans exposed to ticks in midwestern Germany. Journal of Clinical Microbiology 40, 2431–2436.CrossRefGoogle Scholar
INOKUMA, H., BROUQUI, P., DRANCOURT, M. & RAOULT, D. ( 2001). Citrate synthase gene sequence: a new tool for phylogenetic analysis and identification of Ehrlichia. Journal of Clinical Microbiology 39, 3031–3039.CrossRefGoogle Scholar
JAMES, A. M., LIVERIS, D., WORMSER, G. P., SCHWARTZ, I., MONTECALVO, M. A. & JOHNSON, B. J. ( 2001). Borrelia lonestari infection after a bite by an Amblyomma americanum tick. Journal of Infectious Diseases 183, 1810–1814.CrossRefGoogle Scholar
JELLISON, W. L. ( 1974). Tularemia in North America. University of Montana, Missoula, USA.
JELLISON, W. L. & PARKER, R. R. ( 1944). Rodents, rabbits and tularemia in North America: some zoological and epidemiological considerations. American Journal of Tropical Medicine 25, 349–362.Google Scholar
JOYNER, L. P., DAVIES, S. F. M. & KENDALL, S. B. ( 1963). The experimental transmission of Babesia divergens by Ixodes ricinus. Experimental Parasitology 14, 367–373.CrossRefGoogle Scholar
JUSTE, R. A., SCOTT, G. R., PAXTON, E. A., GELABERT, J. L. & JIMENEZ, S. ( 1989). Presence of Cytoecetes phagocytophila in an atypical disease of cattle in Spain. Veterinary Record 124, 636.CrossRefGoogle Scholar
KAISER, R. ( 1996). Tick-borne encephalitis in southwestern Germany. Infection 24, 398–399.CrossRefGoogle Scholar
KAWAHARA, M., ITO, T., SUTO, C., SHIBATA, S., RIKIHISA, Y., HATA, K. & KIRAI, K. ( 1999). Comparison of Ehrlichia muris strains isolated from wild mice and ticks and serologic survey of humans and animals with E. muris as antigen. Journal of Clinical Microbiology 37, 1123–1129.Google Scholar
KAWAMURA, R. ( 1926). Studies onTsutsugamushi Disease (Japanese Flood Fever). Spokesman Printing Company, Cincinnati, USA.
KELLY, P. J., BEATI, L., MASON, P. R., MATTHEWMAN, L. A., ROUX, V. & RAOULT, D. ( 1996). Rickettsia africae sp. nov., the etiological agent of African tick bite fever. International Journal of Systematic Bacteriology 46, 611–614.Google Scholar
KELLY, P. J., MASON, P. R., MATTHEWMAN, L. A. & RAOULT, D. ( 1991). Seroepidemiology of Spotted-Fever Group Rickettsial infections in humans in Zimbabwe. Journal of Tropical Medicine and Hygiene 94, 304–309.Google Scholar
KEYSARY, A., AMRAM, L., KEREN, G., STOEGER, Z., POTASMAN, I., JACOB, A., STRENGER, C., DAWSON, J. E. & WANER, T. ( 1999). Serologic evidence of human monocytic and granulocytic ehrlichiosis in Israel. Emerging Infectious Diseases 5, 775–778.CrossRefGoogle Scholar
KIM, C. M., KIM, M. S., PARK, J. H. & CHAE, J. S. ( 2003). Identification of Ehrlichia chaffeensis, Anaplasma phagocytophilum, and Anaplasma bovis in Haemaphysalis longicornis and Ixodes persulcatus ticks from Korea. Vector Borne and Zoonotic Diseases 3, 17–26.CrossRefGoogle Scholar
KJEMTRUP, A. M., THOMFORD, J., ROBINSON, T. & CONRAD, P. A. ( 2000). Phylogenetic relationships of human and wildlife piroplasm isolates in the western United States inferred from the 18S nuclear small subunit RNA gene. Parasitology 120, 487–493.CrossRefGoogle Scholar
KOKERNOT, R. H., CALISHER, C. H., STANNARD, L. J. & HAYES, J. ( 1969). Arbovirus studies in the Ohio–Mississippi basin 1964–1967. VII. Lone Star virus, a hitherto unknown agent isolated from the tick Amblyomma americanum. American Journal of Tropical Medicine and Hygiene 18, 789–795.Google Scholar
KORDICK, S. K., BREITSCHWERDT, E. B., HEGARTY, B. C., SOUTHWICK, K. L., COLITZ, C. M., HANCOCK, S. I., BRADLEY, J. M., RUMBOUGH, R., McPHERSON, J. T. & MACCORMACK, J. N. ( 1999). Coinfection with multiple tick-borne pathogens in a Walker Hound kennel in North Carolina. Journal of Clinical Microbiology 37, 2631–2638.Google Scholar
KOZUCK, O., GRESIKOVA, M., NOSEK, J., LICHARD, M. & SEKEYOVA, M. ( 1967). The role of small rodents and hedgehogs in a natural focus of tick-borne encephalitis. Bulletin of the World Health Organisation 36, 61–66.Google Scholar
KRAMPITZ, H. E. & BAUMLER, W. ( 1978). Occurrence, host range and seasonal prevlance of Babesia microti (Franca 1912) in rodents in Southern Germany. Zeitschrift für Parasitenkunde 58, 15–33.CrossRefGoogle Scholar
KRAMPITZ, H. E. & KLEINSCHMIDT, A. ( 1960). Grahamella Brumpt 1911 biologische und morphologische Untersuchungen. Zeitschrift fürTropenmedizine und Parasitologie 11, 336–352.Google Scholar
KRAUSE, P. J., TELFORD, S. R. 3rd, SPIELMAN, A., SIKAND, V., RYAN, R., CHRISTIANSON, D., BURKE, G., BRASSARD, P., POLLACK, R., PECK, J. & PERSING, D. H. ( 1996). Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. Journal of the American Medical Association 275, 1657–1660.CrossRefGoogle Scholar
KRINSKY, W. L. & BURGDORFER, W. ( 1976). Trypanosomes in Amblyomma americanum from Oklahoma. Journal of Parasitology 62, 824–825.CrossRefGoogle Scholar
KUNZ, C. ( 1992). Tick-borne encephatitis in Europe. Acta Leidensia 60, 1–4.Google Scholar
LABUDA, M., NUTTALL, P. A., KOZUCH, O., ELECKOVA, E., WILLIAMS, T., ZUFFOVA, E. & SABO, A. ( 1993). Non-viraemic transmission of tick-borne encephalitis virus: a mechanism for arbovirus survival in nature. Experientia 49, 802–805.CrossRefGoogle Scholar
LAKOS, A. & RAOULT, D. ( 1999). Tick-borne lymphadenopathy (TIBOLA), a Rickettsia slovaca infection? In Rickettsiae and Rickettsial Diseases at the Turn of the Third Millenium (ed. Raoult, D. & Brouqui, P.), pp. 258–261. Elsevier, Paris.
LEBECH, A. M., HANSEN, K., PANCHOLI, P., SLOAN, L. M., MAGERA, J. M. & PERSING, D. H. ( 1998). Immunoserologic evidence of Human Granulocytic Ehrlichiosis in Danish patients with Lyme neuroborreliosis. Scandinavian Journal of Infectious Diseases 30, 173–176.Google Scholar
LEMON, S. M. & BROWN, E. A. ( 1995). Hepatitis C virus. In Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases, 4th edition. ( ed. Mandell, G. L., Bennett, J. E. & Dolin, R.), pp. 1474–1486. Churchill Livingstone, New York.
LEVIN, M. L. & FISH, D. ( 2000). Immunity reduces reservoir host competence of Peromyscus leucopus for Ehrlichia phagocytophila. Infection and Immunity 68, 1514–1518.CrossRefGoogle Scholar
LITTLE, S. E., DAWSON, J. E., LOCKHART, J. M., STALLKNECHT, D. E., WARNER, C. K. & DAVIDSON, W. R. ( 1997). Development and use of specific polymerase chain reaction for the detection of an organism resembling Ehrlichia sp. in white-tailed deer. Journal of Wildlife Diseases 33, 246–253.CrossRefGoogle Scholar
LOCKHART, J. M., DAVIDSON, W. R., DAWSON, J. E. & STALLKNECHT, D. E. ( 1995). Temporal association of Amblyomma americanum with the presence of Ehrlichia chaffeensis reactive antibodies in white-tailed deer. Journal of Wildlife Diseases 31, 119–124.CrossRefGoogle Scholar
LOCKHART, J. M., DAVIDSON, W. R., STALLKNECHT, D. E., DAWSON, J. E. & HOWERTH, E. W. ( 1997 a). Isolation of Ehrlichia chaffeensis from wild white-tailed deer (Odocoileus virginianus) confirms their role as natural reservoir hosts. Journal of Clinical Microbiology 35, 1681–1686.Google Scholar
LOCKHART, J. M., DAVIDSON, W. R., STALLKNECHT, D. E., DAWSON, J. E. & LITTLE, S. E. ( 1997 b). Natural history of Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae) in the piedmont physiographic province of Georgia. Journal of Parasitology 83, 887–894.Google Scholar
LUDHAM, G. B., BRIDGES, J. B. & BENN, E. C. ( 1964). Association of Stevens–Johnson syndrome with antibodies for Mycoplasma pneumoniae. Lancet 1, 958–959.Google Scholar
LVOV, D. K. ( 1986). Omsk hemorrhagic fever. In The Arboviruses: Epidemiology and Ecology, Volume III (ed. Monath, T. P.), pp. 205–216. CRC Press, Boca Raton, USA.
MAHARA, F. ( 1984). Three Weil-Felix (OX2) positive cases with skin eruptions and high fever. Journal of Anan Medical Association 68, 4–7.Google Scholar
MAHARA, F. ( 1997). Japanese spotted fever: Report of 31 cases and review of the literature. Emerging Infectious Diseases 3, 105–111.CrossRefGoogle Scholar
MAIN, A. J. & CAREY, A. B. ( 1980). Connecticut virus – A new sawgrass group virus from Ixodes dentatus (Acari, Ixodidae). Journal of Medical Entomology 17, 473–476.CrossRefGoogle Scholar
MAKINEN, J., VUORINEN, I., OKSI, J., PELTOMAA, M., HE, Q., MARJAMAKI, M. & VILJANEN, M. K. ( 2003). Prevalence of granulocytic Ehrlichia and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected from Southwest Finland and from Vormsi Island in Estonia. APMIS 111, 355–362.CrossRefGoogle Scholar
MARCONI, R. T., LIVERIS, D. & SCHWARTZ, I. ( 1995). Identification of novel insertion elements, restriction fragment length polymorphisms patterns, and discontinuous 23SrRNA in Lyme disease spirochetes: phylogenetic analyses of rRNA genes and their intergenic spacers in Borrelia japonica sp. nov. and genomic group 21038 (Borrelia andersoni sp. nov.) isolates. Journal of Clinical Microbiology 33, 2427–2434.Google Scholar
MARTIN, P. A. & SCHMIDTMANN, E. T. ( 1998). Isolation of aerobic microbes from Ixodes scapularis (Acari: Ixodidae), the vector of Lyme disease in the eastern United States. Journal of Economic Entomology 91, 864–868.CrossRefGoogle Scholar
MASON, J. H. & ALEXANDER, R. A. ( 1939). Studies of the rickettsias of the typhus-Rocky Mountain spotted fever group in South Africa. III. The disease in the experimental animal. Cross-immunity tests. Onderstepoort Journal of Veterinary Animal Industry 13, 41–66.Google Scholar
MASSUNG, R. F., MAUEL, M., OWENS, J. H., ALLAN, N., COURTNEY, J. W., STAFFORD, K. C. 3rd & MATHER, T. N. ( 2002). Genetic variants of Ehrlichia phagocytophila, Rhode Island and Connecticut. Emerging Infectious Diseases 8, 467–472.CrossRefGoogle Scholar
MASTERS, E., GRANTER, S., DURAY, P. & CORDES, P. ( 1998). Physician-diagnosed erythema migrans and erythema migrans-like rashes following Lone Star tick bites. Archives of Dermatology 134, 955–960.CrossRefGoogle Scholar
MASTERS, E. J. & DONNELL, H. D. ( 1995). Lyme and/or Lyme-like disease in Missouri. Missouri Medicine 92, 346–353.Google Scholar
MAXEY, E. E. ( 1899). Some observations on the so-called spotted fever of Idaho. Medical Sentinel of Portland 7, 433–438.Google Scholar
McQUISTON, J. H., PADDOCK, C. D., HOLMAN, R. C. & CHILDS, J. E. ( 1999). The human ehrlichioses in the United States. Emerging Infectious Diseases 5, 635–642.CrossRefGoogle Scholar
MEGAW, J. W. ( 1921). A typhus like fever in India, possibly transmitted by ticks. Indian Medical Gazette 56, 361–371.Google Scholar
MONTEIRO, J. L., FONSECA, F. & PRADO, A. ( 1931). Pesquisas epidemiologicas sobre o typhus exanthematico de Sao Paolo. Memorias Institutio Butantan 6, 139–173.Google Scholar
MORAIS, J. D., DAWSON, J. E., GREENE, C., FILIPE, A. R., GALHARDAS, L. C. & BACELLAR, F. ( 1991). First European case of ehrlichiosis (letter). Lancet 338, 633–634.CrossRefGoogle Scholar
MURPHY, G. L., EWING, S. A., WHITWORTH, L. C., FOX, J. C. & KOCAN, A. A. ( 1998). A molecular and serologic survey of Ehrlichia canis, E. chaffeensis, and E. ewingii in dogs and ticks from Oklahoma. Veterinary Parasitology 79, 325–339.Google Scholar
NADELMAN, R. B., HERMAN, E. & WORMSER, G. P. ( 1997). Screening for Lyme disease in hospitalized psychiatric patients: prospective serosurvey in an endemic area. Mount Sinai Journal of Medicine 64, 409–412.Google Scholar
NIEBYLSKI, M. L., PEACOCK, M. G., FISCHER, E. R., PORCELLA, S. F. & SCHWAN, T. G. ( 1997 a). Characterization of an endosymbiont infecting wood ticks, Dermacentor andersoni, as a member of the genus Francisella. Applied and Environmental Microbiology 63, 3933–3940.Google Scholar
NIEBYLSKI, M. L., SCHRUMPF, M. E., BURGDORFER, W., FISCHER, E. R., GAGE, K. L. & SCHWAN, T. G. ( 1997 b). Rickettsia peacockii sp. nov., a new species infecting wood ticks, Dermacentor andersoni, in western Montana. International Journal of Systematic Bacteriology 47, 446–452.Google Scholar
NILSSON, K., LINDQUIST, O., LIU, A. J., JAENSON, T. G. T., FRIMAN, G. & PAHLSON, C. ( 1999 a). Rickettsia helvetica in Ixodes ricinus ticks in Sweden. Journal of Clinical Microbiology 37, 400–403.Google Scholar
NILSSON, K., LINDQUIST, O. & PAHLSON, C. ( 1999 b). Association of Rickettsia helvetica with chronic perimyocarditis in sudden cardiac death. Lancet 354, 1169–1173.Google Scholar
NILSSON, K., PAHLSON, C., LUKINIUS, A., ERIKSSON, L., NILSSON, L. & LINDQUIST, O. ( 2001). Presence of Rickettsia helvetica in granulomatous tissue from patients with sarcoidosis. Journal of Infectious Diseases 185, 1128–1138.Google Scholar
NODA, H., MUNDERLOH, U. G. & KURTTI, T. J. ( 1997). Endosymbionts of ticks and their relationship to Wolbachia spp. and tick-borne pathogens of humans and animals. Applied and Environmental Microbiology 63, 3926–3932.Google Scholar
NOGUCHI, H. ( 1926). The experimental transmission of Bartonella bacilliformis by ticks (Dermacentor andersoni). Journal of Experimental Medicine 44, 729–734.CrossRefGoogle Scholar
NORVAL, R. A. I. ( 1977 a). Ecology of the tick Amblyomma hebraeum Koch in Eastern Cape Province of South Africa. 1. Distribution and seasonal activity. Journal of Parasitology 63, 734–739.Google Scholar
NORVAL, R. A. I. ( 1977 b). Studies on ecology of the tick Amblyomma hebraeum Koch in Eastern Cape-Province of South Africa. 2. Survival and development. Journal of Parasitology 63, 740–747.Google Scholar
NUTI, M., SERAFINI, D. A., BASSETTI, D., GHIONNI, A., RUSSINO, F., ROMBOLA, P., MACRI, G. & LILLINI, E. ( 1998). Ehrlichia infection in Italy. Emerging Infectious Diseases 4, 663–665.CrossRefGoogle Scholar
OGDEN, N. H., BOWN, K., HORROCKS, B. K., WOLDEHIWET, Z. & BENNETT, M. ( 1998). Granulocytic Ehrlichia infection in ixodid ticks and mammals in woodlands and uplands of the UK. Medical and Veterinary Entomology 12, 423–429.CrossRefGoogle Scholar
OKSI, J., VILJANEN, M. K., KALIMO, H., PELTONEN, R., MARTTIA, R., SALOMAA, P., NIKOSKELAINEN, J., BUDKA, H. & HOLONEN, P. ( 1993). Fatal encephalitis caused by concomitant infection with tick-borne encephalitis virus and Borrelia burgdorferi. Clinical Infectious Diseases 16, 392–396.CrossRefGoogle Scholar
OLIVER, J. H. Jr., OWSLEY, M. R., HUTCHESON, H. J., JAMES, A. M., CHEN, C., IRBY, W. S., DOTSON, E. M. & McCLAIN, D. K. ( 1993). Conspecificity of the ticks Ixodes scapularis and Ixodes dammini (Acari: Ixodidae). Journal of Medical Entomology 30, 54–63.CrossRefGoogle Scholar
OLSUFIEV, N. G., EMELYANOVA, O. S. & DUNAYEVA, T. N. ( 1959). Comparative study of strains of B. tularense. II. Evaluation of criteria of virulence of Bacterium tularense in the old and new world and their taxonomy. Journal of Hygiene Epidemiology Microbiology and Immunology 3, 138–149.Google Scholar
O'NEILL, S. L., GIORDANO, R., COLBERT, A. M. E., KARR, T. L. & ROBERTSON, H. M. ( 1992). 16s ribosomal RNA phylogenetic analysis of the bacterial endosymbionts associatied with cytoplasmic incompatibility in insects. Proceedings of the National Academy of Sciences, USA 89, 2699–2702.CrossRefGoogle Scholar
OSORNO, B. M., VEGA, C., RISTIC, M., ROBLES, C. & IBARRA, S. ( 1976). Isolation of Babesia spp. from asymptomatic human beings. Veterinary Parasitology 2, 111–120.CrossRefGoogle Scholar
OTEO, J. A., BLANCO, J. R., MARTINEZ DE ARTOLA, V. & IBARRA, V. ( 2000). First report of human granulocytic ehrlichiosis from southern Europe (Spain). Emerging Infectious Diseases 6, 430–432.CrossRefGoogle Scholar
OTEO, J. A. & IBARRA, V. ( 2002). DEBONEL (Dermacentor-borne-necrosis-erythemalymphadenopathy). A new tick-borne disease? Enfermedades Infecciosas y Microbiologia Clinica 20, 51–52.CrossRefGoogle Scholar
PADDOCK, C. D., FOLK, S. M., SHORE, G. M., MACHADO, L. J., HUYCKE, M. M., SLATER, L. N., LIDDELL, A. M., BULLER, R. S., STORCH, G. A., MONSON, T. P., RIMLAND, D., SUMNER, J. W., SINGLETON, J., BLOCH, K. C., TANG, Y. W., STANDAERT, S. M. & CHILDS, J. E. ( 2001). Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus. Clinical Infectious Diseases 33, 1586–1594.CrossRefGoogle Scholar
PARKER, R. R., SPENCER, R. R. & FRANCIS, E. ( 1924). Tularemia infection in ticks of the species Dermacentor andersoni Stiles in the Bitterroot Valley, Montana. Public Health Reports 39, 1057–1073.CrossRefGoogle Scholar
PAROLA, P., CORNET, J.-P., SANOGO, Y. O., MILLER, R. S., GONZALEZ, J.-P., RAOULT, D., TELFORD, S. R. I. & WONGSRICHANALAI, C. ( 2003). Identification of new Ehrlichia, Anaplasma, and Rickettsia genotypes in ticks from the Thai-Myanmar border and Vietnam. Journal of Clinical Microbiology 41, 1600–1608.CrossRefGoogle Scholar
PAROLA, P., VESTRIS, G., MARTINEZ, D., BROCHIER, B., ROUX, V. & RAOULT, D. ( 1999). Tick-borne rickettsiosis in Guadeloupe, the French West Indies: isolation of Rickettsia africae from Amblyomma variegatum ticks and serosurvey in humans, cattle, and goats. American Journal of Tropical Medicine and Hygiene 60, 888–893.CrossRefGoogle Scholar
PAROLA, P. P. & RAOULT, D. R. ( 2000). New tick-transmitted rickettsial diseases. In Tick-borne Infectious Diseases: Diagnosis and Management (ed. Cunha, B. A.), pp. 233–250. Marcel Dekker Inc., New York.CrossRef
PAVLOVSKY, E. N. ( 1966). Natural Nidality of Transmissible Diseases. University of Illinois Press, Urbana.CrossRef
PEGRAM, P. S. Jr., SESSLER, C. N., LONDON, W. L. & BURGDORFER, W. ( 1983). Lyme disease in North Carolina. Southern Medical Journal 76, 740–742.CrossRefGoogle Scholar
PEREZ, M., RIKIHISA, Y. & WEN, B. H. ( 1996). Ehrlichia canis-like agent isolated from a man in Venezuela: Antigenic and genetic characterization. Journal of Clinical Microbiology 34, 2133–2139.Google Scholar
PERSING, D. H., HERWALDT, B. L., GLASER, C., LANE, R. S., THOMFORD, J. W., MATHIESEN, D., KRAUSE, P., PHILLIP, D. F. & CONRAD, P. A. ( 1995). Infection with a Babesia-like organism in northern California. New England Journal of Medicine 332, 298–303.CrossRefGoogle Scholar
PETROVEC, M., LOTRIC FURLAN, S., ZUPANC, T. A., STRLE, F., BROUQUI, P., ROUX, V. & DUMLER, J. S. ( 1997). Human disease in Europe caused by a granulocytic Ehrlichia species. Journal of Clinical Microbiology 35, 1556–1659.Google Scholar
PHILIP, C. B., HOOGSTRAAL, H., REISS-GUTFREUND, R. & CLIFFORD, C. M. ( 1966). Evidence of rickettsial disease agents in ticks from Ethiopian cattle. Bulletin of the World Health Organisation 35, 127–131.Google Scholar
PIERARD, D., LEVTCHENKO, E., DAWSON, J. E. & LAUWERS, S. ( 1995). Ehrlichiosis in Belgium. Lancet 346, 1233–1234.CrossRefGoogle Scholar
PIESMAN, J., MATHER, T. N., TELFORD, S. R. 3rd & SPIELMAN, A. ( 1986). Concurrent Borrelia burgdorferi and Babesia microti infection in nymphal Ixodes dammini. Journal of Clinical Microbiology 24, 446–447.Google Scholar
PIJPER, A. ( 1936). Etude experimentale comparee de la fievre boutonneuse et de tick bite fever. Archives du Institut Pasteur Tunis 25, 388–401.Google Scholar
POMERANTSEV, B. I. ( 1959). Ixodid Ticks (Ixodidae). American Institute of Biological Sciences, Washington, DC.
PRETORIUS, A.-M. & BIRTLES, R. J. ( 2002) Rickettsia aeschlimannii: a new pathogenic spotted fever group rickettsia, South Africa. Emerging Infectious Diseases 8, 874.CrossRefGoogle Scholar
QUICK, R. E., HERWALDT, B. L., THOMFORD, J. W., GARNETT, M. E., EBERHARD, M. L., WILSON, M., SPACH, D. H., DICKERSON, J. W., TELFORD, S. R. 3rd & STEINGART, K. R. ( 1993). Babesiosis in Washington State: a new species of Babesia? Annals of Internal Medicine 119, 284–290.Google Scholar
RANDOLPH, S. E. ( 2002). Predicting the risk of tick-borne diseases. International Journal of Medical Microbiology 291, S33, 6–10.CrossRefGoogle Scholar
RANDOLPH, S. E., MIKLISOVA, D., LYSY, J., ROGERS, D. J. & LABUDA, M. ( 1999) Incidence from coincidence: patterns of tick infestations on rodents facilitate transmission of tick-borne encephalitis virus. Parasitology 118, 177–186.CrossRefGoogle Scholar
RANDOLPH, S. E. & ROGERS, D. J. ( 2000). Fragile transmission cycles of tick-borne encephalitis virus may be disrupted by predicted climate change. Proceedings of the Royal Society of London, B 267, 1741–1744.CrossRefGoogle Scholar
RAOULT, D., BERBIS, P., ROUX, V., XU, W. & MAURIN, M. ( 1997). A new tick-transmitted disease due to Rickettsia slovaca. Lancet 350, 112–113.CrossRefGoogle Scholar
RAOULT, D., BROUQUI, P. & ROUX, V. ( 1996). A new spotted fever group rickettsiosis. Lancet 348, 412.CrossRefGoogle Scholar
REHACEK, J. ( 1962). Transovarial transmission of tick-borne encephalitis virus by ticks. Acta Virologica 6, 220–222.Google Scholar
REID, H. W. ( 1986). Louping Ill. In The Arboviruses: Epidemiology and Ecology, Volume III (ed. Monath, T. P.), pp. 117–135. CRC Press, Boca Raton, USA.
RELMAN, D. A. ( 2002). Mining the world for new pathogens. American Journal of Tropical Medicine and Hygiene 67, 133–134.CrossRefGoogle Scholar
RICH, S. M., ARMSTRONG, P. M., SMITH, R. D. & TELFORD, S. R. ( 2001). Lone star tick-infecting borreliae are most closely related to the agent of bovine borreliosis. Journal of Clinical Microbiology 39, 494–497.CrossRefGoogle Scholar
RICHMOND, J. Y. & McKINNEY, R. W. ( 1993). Biosafety in Microbiological and Biomedical Laboratories, 3rd edition. Washington, DC, US Department of Health and Human Services.
RICHTER, P. J. Jr., KIMSEY, R. B., MADIGAN, J. E., BARLOUGH, J. E., DUMLER, J. S. & BROOKS, D. L. ( 1996). Ixodes pacificus (Acari: Ixodidae) as a vector of Ehrlichia equi (Rickettsiales: Ehrlichieae). Journal of Medical Entomology 33, 1–5.CrossRefGoogle Scholar
RICKETTS, H. T. ( 1906). The transmission of Rocky Mountain spotted fever by the bite of the wood tick (Dermacentor occidentalis). Journal of the American Medical Association 47, 358.CrossRefGoogle Scholar
RIPOLL, C. M., REMONDEGUI, C. E., ORDONEZ, G., ARAZAMENDI, R., FUSARO, H., HYMAN, M. J., PADDOCK, C. D., ZAKI, S. R., OLSON, J. G. & SANTOS-BUCH, C. A. ( 1999). Evidence of rickettsial spotted fever and ehrlichial infections in a subtropical territory of Jujuy, Argentina. American Journal of Tropical Medicine and Hygiene 61, 350–354.CrossRefGoogle Scholar
RISTIC, M. ( 1968). Anaplasmosis. In Infectious Blood Diseases of Man and Animals (ed. Weinman, D. & Ristic, M.), pp. 478–542. Academic Press, New York.CrossRef
RIVERS, T. M. & SCHWENTKER, F. F. ( 1934). Louping ill in man. Journal of Experimental Medicine 59, 669–685.CrossRefGoogle Scholar
ROBERTS, D., WANG, X., KEMP, R. G. & FELZ, M. W. ( 1999). Solitary erythema migrans in Georgia and South Carolina. Archives of Biochemistry and Biophysics 371, 326–331.Google Scholar
ROBERTSON, R. G. & WISSEMAN, C. L. ( 1973). Tick-borne rickettsiae of the spotted fever group in West Pakistan. II. Serological classification of isolates from West Pakistan and Thailand: evidence for two new species. American Journal of Epidemiology 97, 55–64.CrossRefGoogle Scholar
ROOT, R. B. ( 1967). The niche exploitation pattern of the blue-gray gnatcatcher. Ecological Monographs 37, 317–350.CrossRefGoogle Scholar
ROUX, V. & RAOULT, D. ( 1999). Phylogenetic analysis and taxonomic relationships among the genus Rickettsia. In Rickettsiae and Rickettsial Diseases of the Third Millenium (ed. Raoult, D. & Brouqui, P.), pp. 52–66. Elsevier, Amsterdam.
SALGO, M. P., TELZAK, E. E., CURRIE, B., PERLMAN, D. C., LITMAN, N., LEVI, M., NATHENSON, G., BENACH, J. L, AL-HAFIDH, R. & CASEY, J. ( 1988). A focus of Rocky Mountain spotted fever within New York city. New England Journal of Medicine 318, 1345–1348.CrossRefGoogle Scholar
SANOGO, Y. O., ZEAITER, Z., CARUSO, G., MEROLA, F., SHPYNOV, S., BROUQUI, P. & RAOULT, D. ( 2003). Detection of Bartonella henselae in ticks Ixodes ricinus (Acari: Ixodidae) removed from humans in Belluno Province, Italy. Emerging Infectious Diseases 9, 329–332.CrossRefGoogle Scholar
SANT'ANA, J. F. ( 1911). On a disease in man following tick bites and occuring in Lourenco Marques. Parasitology 4, 87–88.CrossRefGoogle Scholar
SCHABEREITER-GURTNER, C., LUBITZ, W. & ROLLEKE, S. ( 2003). Application of broad range 16S rRNA PCR amplification and DGGE fingerprinting for detection of tick-infecting bacteria. Journal of Microbiological Methods 52, 251–260.CrossRefGoogle Scholar
SCHOLTEN, R., BRAFF, E. H., HEALY, G. R. & GLEASON, N. ( 1968). A case of babesiosis in man in United States. American Journal of Tropical Medicine and Hygiene 17, 810–813.CrossRefGoogle Scholar
SCHOULS, L. M., VAN DE POL, I., RIJPKEMA, S. G. & SCHOT, C. S. ( 1999). Detection and identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella species in Dutch Ixodes ricinus ticks. Journal of Clinical Microbiology 37, 2215–2222.Google Scholar
SCOTT, G. & WOLDEHIWET, Z. ( 1993). Bovine petechial fever. In Rickettsial and Chlamydial Diseases of Domestic Animals (ed. Woldehiwet, Z. & Ristic, M.), pp. 255–268. Pergamon Press, Oxford.
SHAPIRO, D. S. & MARK, E. J. ( 2000). Case 14-2000 – A 60 year old farm worker with bilateral pneumonia. New England Journal of Medicine 342, 1430–1438.CrossRefGoogle Scholar
SHIBATA, S., KAWAHARA, M., RIKIHISA, Y., FUJITA, H., WATANABE, Y., SUTO, C. & ITO, T. ( 2000). New Ehrlichia species closely related to Ehrlichia chaffeensis isolated from Ixodes ovatus ticks in Japan. Journal of Clinical Microbiology 38, 1331–1338.Google Scholar
SHIH, C. M., LIU, L. P., CHUNG, W. C., ONG, S. J. & WANG, C. C. ( 1997). Human babesiosis in Taiwan: asymptomatic infection with a Babesia microti-like organism in a Taiwanese woman. Journal of Clinical Microbiology 35, 450–454.Google Scholar
SHYPNOV, S., PAROLA, P., RUDAKOV, N., SAMOILENKO, I., TANKIBAEV, M., TARASEVICH, I. & RAOULT, D. ( 2001). Detection and identification of spotted fever group rickettsiae in Dermacentor ticks from Russia and Central Kazakhstan. European Journal of Clinical Microbiology and Infectious Diseases 20, 903–905.CrossRefGoogle Scholar
SHYPNOV, S. S., FOURNIER, P.-E., RUDAKOV, N. & RAOULT, D. ( 2003). “Candidatus Rickettsia tarasevichae” in Ixodes persulcatus ticks collected in Russia. Annals of the New York Academy of Sciences 990, 162–172.CrossRefGoogle Scholar
SIMSER, J. A., PALMER, A. T., FINGERLE, V., WILSKE, B., KURTTI, T. J. & MUNDERLOH, U. G. ( 2002). Rickettsia monacensis sp. nov., a spotted fever group rickettsia, from ticks (Ixodes ricinus) collected in a European city park. Applied and Environmental Microbiology 68, 4559–4566.Google Scholar
SMITH, T. & KILBORNE, F. L. ( 1893). Investigation into the nature, causation, and prevention of Texas or Southern Cattle Fever. Bureau of Animal Industries, Bulletin 1, US Department of Agriculture.CrossRef
SNEATH, P. H. A. ( 1992). International Code of Nomenclature of Bacteria 1990 Revision. American Society for Microbiology, Washington, DC.
SPIELMAN, A. & ROSSIGNOL, P. ( 1984). Insect vectors and scalars. In Tropical and Geographic Medicine ( ed. Warren, K. S. & Mahmoud, A. F.), pp. 167–183. McGraw-Hill, New York.
STENOS, J., ROUX, V., WALKER, D. H. & RAOULT, D. ( 1998). Rickettsia honei sp. nov., the aetiological agent of Flinders Island spotted fever in Australia. International Journal of Systematic Bacteriology 48, 1399–1404.Google Scholar
STEWART, R. S. ( 1991). Flinders Island spotted fever: a newly recognised endemic focus of tick typhus in Bass Strait. Pt. 1. Clinical and epidemiological features. Medical Journal of Australia 154, 94–99.Google Scholar
STUEN, S., VAN DE POL, I., BERGSTROM, K. & SCHOULS, L. A. ( 2002). Identification of Anaplasma phagocytophila (formerly Ehrlichia phagocytophila) variants in blood from sheep in Norway. Journal of Clinical Microbiology 40, 3192–3197.CrossRefGoogle Scholar
SUITOR, E. C. & WEISS, E. ( 1961). Isolation of a Rickettsia-like microorganism (Wolbachia persica n. sp.) from Argas persicus (Oken). Journal of Infectious Diseases 108, 95–99.Google Scholar
SUMPTION, K. J., WRIGHT, D. J., CUTLER, S. J. & DALE, B. A. ( 1995). Human ehrlichiosis in the UK. Lancet 346, 1487–1488.CrossRefGoogle Scholar
SUN, L. V., SCOLES, G. A., FISH, D. & O'NEILL, S. L. ( 2000). Francisella-like endosymbionts of ticks. Journal of Invertebrate Pathology 76, 301–303.CrossRefGoogle Scholar
TARASEVICH, I. V., MAKAROVA, V. A., FETISOVA, N. F., STEPANOV, A. V., MISKAROVA, E. D., BALAYEVA, N. & RAOULT, D. ( 1991). Astrakhan fever: a spotted fever rickettsiosis. Lancet 337, 172–173.CrossRefGoogle Scholar
TARNVIK, A., SANDSTROM, G. & SJOSTEDT, A. ( 1996). Epidemiological analysis of tularemia in Sweden 1931–1993. FEMS Immunology and Medical Microbiology 13, 201–204.CrossRefGoogle Scholar
TELFORD, S. R. ( 1998). The name Ixodes dammini epidemiologically justified. Emerging Infectious Diseases 4, 132–134.CrossRefGoogle Scholar
TELFORD, S. R., ARMSTRONG, P. M., KATAVOLOS, P., FOPPA, I., GARCIA, A. S. O., WILSON, M. L. & SPIELMAN, A. ( 1997). A new tick-borne encephalitis-like virus infecting New England deer ticks, Ixodes dammini. Emerging Infectious Diseases 3, 165–170.CrossRefGoogle Scholar
TELFORD, S. R., DAWSON, J. E., KATAVOLOS, P., WARNER, C. K., KOLBERT, C. P. & PERSING, D. H. ( 1996). Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proceedings of the National Academy of Sciences, USA 93, 6209–6214.CrossRefGoogle Scholar
TELFORD, S. R. & FOPPA, I. M. ( 2000). Tickborne encephalitides. In Tickborne Infectious Diseases, Diagnosis and Management ( ed. Cunha, B. A.), pp. 193–214. Marcel Dekker, New York.CrossRef
TELFORD, S. R., GORENFLOT, A., BRASSEUR, P. & SPIELMAN, A. ( 1993). Babesial infections in humans and wildlife. In Parasitic Protozoa, vol. 5 (ed. Kreier, J. P.), pp. 1–47. Academic Press, San Diego.
TELFORD, S. R. 3rd, KORENBERG, E. I., GOETHERT, H. K., KOVALEVSKY, Y. V., GORELOVA, N. B. & SPIELMAN, A. ( 2002). Detection of natural foci of Babesiosis and granulocytic ehrlichiosis in Russia. Journal of Microbiology Epidemiology and Immunology 6, 21–25.Google Scholar
TELFORD, S. R. 3rd, LEPORE, T. J., SNOW, P., WARNER, C. K. & DAWSON, J. E. ( 1995). Human granulocytic ehrlichiosis in Massachusetts. Annals of Internal Medicine 123, 277–279.CrossRefGoogle Scholar
TELFORD, S. R. 3rd & MAGUIRE, J. H. ( 1999). Babesiosis. In Tropical Infectious Diseases: Priniciples, Pathogens, and Practice, vol. 1 (ed. Guerrant, R., Walker, D. H. & Weller, P. F.), pp. 767–773. Churchill Livingstone, London, UK.
TELFORD, S. R. 3rd & SPIELMAN, A. ( 1993). Reservoir competence of white-footed mice for Babesia microti. Journal of Medical Entomology 30, 223–227.CrossRefGoogle Scholar
TENCKHOFF, B., KOLMEL, H. W., WOLF, V. & LANGE, R. ( 1994). Production and characterization of a polyclonal antiserum against Spiroplasma mirum. Zentralblatt für Bakteriologie 280, 409–415.CrossRefGoogle Scholar
TENTER, A. M., BARTA, J. R., BEVERIDGE, I., DUSZYNSKI, D. W., MEHLHORN, H., MORRISON, D. A., THOMPSON, R. C. A. & CONRAD, P. A. ( 2002). The conceptual basis for a new classification of the coccidia. International Journal for Parasitology 32, 595–616.CrossRefGoogle Scholar
THEIL, K. W., McCLOSKEY, C. M. & SCOTT, D. P. ( 1993). Serologic evidence for rabbit syncytial virus in eastern cottontails (Sylvilagus floridanus) in Ohio. Journal of Wildlife Diseases 29, 470–474.CrossRefGoogle Scholar
THOMFORD, J. W., CONRAD, P. A., BOYCE, W. M., HOLMAN, P. J. & JESSUP, D. A. ( 1993). Isolation and in vitro cultivation of Babesia parasites from free-ranging desert bighorn sheep (Ovis canadensis nelsoni) and mule deer (Odocoileus hemionus) in California. Journal of Parasitology 79, 77–84.CrossRefGoogle Scholar
TREIB, J. ( 1994). First case of tick-borne encephalitis in the Saarland. Infection 22, 368–369.CrossRefGoogle Scholar
TSUJI, M., WEI, Q., ZAMOTO, A., MORITA, C., ARAI, S., SHIOTA, T., FUJIMAGARI, M., ITAGAKI, A., FUJITA, H. & ISHIHARA, C. ( 2001). Human babesiosis in Japan: epizootiologic survey of rodent reservoir and isolation of new type of Babesia microti-like parasite. Journal of Clinical Microbiology 39, 4316–4322.CrossRefGoogle Scholar
TULLY, J. F., ROSE, D. L., YUNKER, C. E., CARLE, P., BOVE, J. M., WILLIAMSON, D. L. & WHITCOMB, R. F. ( 1995). Spiroplasma ixodetis sp. nov., a new species from Ixodes pacificus ticks collected in Oregon. International Journal of Systematic Bacteriology 45, 23–28.Google Scholar
TULLY, J. F., WHITCOMB, R. F., ROSE, D. L., WILLIAMSON, D. L. & BOVE, J. M. ( 1983). Characterisation and taxonomic status of tick spiroplasmas: a review. Yale Journal of Biology and Medicine 56, 599–603.Google Scholar
TYZZER, E. E. ( 1938). Cytoecetes microti, n.g., n.sp., A parasite developing in granulocytes and infective for small rodents. Parasitology 30, 242–257.Google Scholar
TYZZER, E. E. ( 1942). A comparative study of Grahamellae, Haemobartonellae, and Eperythrozoa in small mammals. Proceedings of the American Philosophical Society 85, 359–398.Google Scholar
UCHIDA, T. ( 1993). Rickettsia japonica, the etiologic agent of oriental spotted fever. Microbiology and Immunology 37, 91–102.CrossRefGoogle Scholar
UILENBERG, G. ( 1993). Other ehrlichioses of ruminants. In Rickettsial and Chlamydial Diseases of Domestic Animals (ed. Woldehiwet, Z. & Ristic, M.), pp. 269–279. Pergamon Press, Oxford.
URVOLGYI, J. & BREZINA, R. ( 1978). Rickettsia slovaca – new member of spotted fever-group rickettsiae. Folia Microbiologica 21, 299–305.Google Scholar
VAN PEENEN, P. F., CHANG, S. J., BANKNIEDER, A. R. & SANTANA, F. J. ( 1977). Piroplasms from Taiwanese rodents. Journal of Protozoology 24, 310–312.CrossRefGoogle Scholar
VESTRIS, G., ROLAIN, J. E., FOURNIER, P. E., BIRG, M. L., ENEA, M., PATRICE, J. Y. & RAOULT, D. ( 2003). Seven years' experience of isolation of Rickettsia spp. from clinical specimens using the shell vial cell culture assay. Annals of the New York Academy of Sciences 990, 371–374.Google Scholar
VYROSTEKOVA, V., KHANAKAH, G., KOCIANOVA, E., GURYCOVA, D. & STANEK, G. ( 2002). Prevalence of coinfection with Francisella tularensis in reservoir animals of Borrelia burgdorferi sensu lato. Wiener Klinische Wochenschrift 114, 482–488.Google Scholar
WALKER, D. H. ( 1998). Tick transmitted diseases in the United States. Annual Review of Public Health 19, 237–269.CrossRefGoogle Scholar
WALLS, J. J., GREIG, B., NEITZEL, D. F. & DUMLER, J. S. ( 1997). Natural infection of small mammal species in Minnesota with the agent of human granulocytic ehrlichiosis. Journal of Clinical Microbiology 35, 853–855.Google Scholar
WEDER, B., KETZ, E., MATTER, L. & SCHUMAN, S. H. ( 1989). Lyme and other tick-borne diseases acquired in South Carolina in 1988: a survey of 1,331 physicians. Journal of Neurology 236, 305–306.Google Scholar
WELCH, D. F., CARROLL, K. C., HOFMEISTER, E. K., PERSING, D. H., ROBISON, D. A., STEIGERWALT, A. G. & BRENNER, D. J. ( 1999). Isolation of a new subspecies, Bartonella vinsonii subsp. arupensis, from a cattle rancher: Identity with isolates found in conjunction with Borrelia burgdorferi and Babesia microti among naturally infected mice. Journal of Clinical Microbiology 37, 2598–2601.Google Scholar
WELLER, S. J., BALDRIDGE, G. D., MUNDERLOH, U. G., NODA, H., SIMSER, J. & KURTTI, T. J. ( 1998). Phylogenetic placement of rickettsiae from the ticks Amblyomma americanum and Ixodes scapularis. Journal of Clinical Microbiology 36, 1305–1317.Google Scholar
WELLMER, H. & JUSATZ, H. J. ( 1981). Geoecological analyses of the spread of tick borne encephalitis in Central Europe. Social Science and Medicine – Medical Geography 15D, 159–162.CrossRefGoogle Scholar
WESSLEN, L. ( 2001). Sudden cardiac death in Swedish orienteers. PhD thesis. Uppsala University.
WOLBACH, S. B. ( 1919). Studies on Rocky Mountain spotted fever. Journal of Medical Research XLI, 1–197.Google Scholar
WOLDEHIWET, Z., CARTER, S. D. & DARE, C. ( 1991). Purification of Cytoecetes phagocytophila, the causative agent of tick-borne fever, from peripheral blood of infected sheep. Journal of Comparative Pathology 105, 431–438.CrossRefGoogle Scholar
WOLDEHIWET, Z. & SCOTT, G. R. ( 1993). Tick-borne (pasture) fever. In Rickettsial and Chlamydial Diseases of Domestic Animals (ed. Woldehiwet, Z. & Ristic, M.), pp. 233–254. Pergamon Press Ltd., Oxford, England.
WOOD, W. W. ( 1896). Spotted Fever as Reported from Idaho. US Government, Washington, DC.
WURZEL, L. G., CABLE, R. G. & LEIBY, D. A. ( 2002). Can ticks be vectors for hepatitis C virus? New England Journal of Medicine 347, 1724–1725.Google Scholar
YABSLEY, M. J., VARELA, A. S., TATE, C. M., DUGAN, V. G., STALLKNECHT, D. E., LITTLE, S. E. & DAVIDSON, W. R. ( 2002). Ehrlichia ewingii infection in white-tailed deer (Odocoileus virginianus). Emerging Infectious Diseases 8, 668–671.CrossRefGoogle Scholar
YOUNG, A. S. & MORZARIA, S. P. ( 1986). Biology of Babesia. Parasitology Today 2, 211–219.CrossRefGoogle Scholar
ZAHLER, M., RINDER, H., SCHEIN, E. & GOTHE, R. ( 2000). Detection of a new pathogenic Babesia microti-like species in dogs. Veterinary Parasitology 89, 241–248.CrossRefGoogle Scholar
ZANOTTO, P. M., GAO, G. F., GRITSUN, T., MARIN, M., JIANG, W. R., VENUGOPAL, K., REID, H. W. & GOULD, E. A. ( 1995). An arbovirus cline across the northern hemisphere. Virology 210, 152–159.CrossRefGoogle Scholar
ZAVALA-VELAZQUEZ, J. E., RUIZ SOSA, J., VADO SOLIS, I., BILLINGS, A. N. & WALKER, D. H. ( 1999). Serologic study of the prevalence of rickettsiosis in Yucatan: evidence for a prevalent spotted fever group rickettsiosis. American Journal of Tropical Medicine and Hygiene 61, 405–408.CrossRefGoogle Scholar
ZDRODOWSKI, P. F. & GOLINEVICH, H. M. ( 1960). The Rickettsial Diseases. Pergamon Press, New York.