Objective: To evaluate the effects of paclitaxel liposome and 5fluorouracil(5FU), cisplatin(CDDP) as preoperative regional intraarterial infusion chemotherapy in advanced gastric cancer(AGC).
Methods: Eightyfour patients with clinical stagesⅡ-Ⅳgastric carcinoma were submitted to preoperative regionalarterial infusion chemotherapy. The regimen consisting of paclitaxel liposome 135 mg/m,cisplatin 60 mg/m and 5FU 1 000 mg/m,was administrated 7-10days before operation. Another 78 patients with similar GC staging, treated during the same period, underwent routine surgery directly. The response of the primary tumor to neoadjuvant chemotherapy and chemotherapy toxicity, and differences in outcome were observed of the 2 groups.
Results: Among the 78 patients undergoing surgery directly, 48 cases(61.5%)had curative resection,and the 1 year survival rate was 74.3%. All 84 patients of the neoadjuvant chemotherapy group completed the planned regimen of chemotherapy and surgery successfully. The most common related adverse effects In neoadjurant group were grade 1-2 gastrointestinal reactions and bone marrow depression.in neoadjurant group, 66 cases(78.5%) underwent curative  resection, and the 1 year survival rate was 80.9%, but, compared to comtrol group, there was no significant difference in survival rate (P=0.283).
Conclusions: Neoadjuvant intraarterial infusion chemotherapy(5fluorouracil, paclitaxel liposome and cisplatin) has been wellrated; it appears to improve the resectable rate of the AGC patients. However, the shortterm outcome of the 2 groups was not significantly different, which may be related to the small number of cases and limited followup period,and this needs continued further investigation.