J Korean Med Assoc > Volume 66(10); 2023 > Article |
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Therapy | Study | Study design | Study protocol | Results |
---|---|---|---|---|
Primary treatment | Rauch et al. [22] | Prospective, randomized, noninferiority study | IT vs. OS | IT for primary therapy was not inferior to OS treatment. |
Lim et al. [23] | Prospective, randomized, controlled study | IT vs. OS vs. IT+OS | Three different treatment protocols resulted in similar hearing recovery rates. | |
Filipo et al. [24] | Prospective, randomized, triple-blind, controlled study | IT steroid vs. IT saline | IT steroid demonstrated a significant therapeutic action compared to the control. | |
Primary combined treatment | Gundogan et al. [25] | Prospective, randomized, controlled study | IT+OS vs. OS | Combination therapy showed significant hearing improvement and speech discrimination scores. |
Koltsidopoulos et al. [26] | Prospective, quasi-randomized, clinical study | IT+OS vs. IV+OS | IT+OS was more effective in patients with moderate to severe hearing loss. | |
Ahn et al. [27] | Prospective, randomized, controlled study | IT+OS vs. OS | IT+OS did not result in significant improvements. | |
Salvage treatment | Lee et al. [28] | Prospective, case-control, randomized study | OS+salvage IT vs. OS | Salvage IT may be simple, effective second-line treatment of choice for the patients who show poor response to initial treatments. |
Wu et al. [3] | prospective, randomized, double-blind, controlled study | IV+OS+salvage IT steroid vs. IV+OS+salvage IT saline | IT steroid was beneficial as a salvage therapy. | |
Zhou et al. [29] | Prospective, randomized study | IV+OS+salvage IT vs. IV+OS | Early salvage IT showed better outcome. |
Therapy | Study | Study design | Study protocol | Results |
---|---|---|---|---|
Steroid | Garduño-Anaya et al. [36] | Prospective, randomized double-blind, controlled study | IT steroid vs. IT placebo | IT steroid showed better results in complete control of vertigo and improvement in other subjective symptoms. |
Albu et al. [35] | Prospective, randomized, double-blind study | IT steroid+PO placebo vs. IT saline+PO betahistine | high-dosage of betahistine achieved similar outcomes as IT steroid in the control of vertigo and hearing preservation. | |
Silverstein et al. [38] | Prospective, randomized, double-blind, crossover study | IT steroid vs. IT placebo | IT steroid showed no benefit over placebo. | |
Patel et al. [37] | Prospective, randomized, double-blind, comparative effectiveness study | IT steroid vs. IT gentamicin | No significant difference between gentamicin and methylprednisolone at controlling vertigo. | |
Gentamicin | Postema et al. [43] | Prospective, randomized, double-blind, controlled study | IT gentamicin vs. IT placebo | IT gentamicin resulted in a significant reduction of the score for vertigo complaints and the score for perceived aural fullness. |
Stokroos and Kingma [44] | Prospective, randomized, double-blind, controlled study | IT gentamicin vs. IT placebo | IT gentamicin causes a significant reduction in the number of vertiginous spells. | |
Bremer et al. [41] | Prospective, randomized, double-blind, controlled study | IT gentamicin vs. IT placebo | No conclusions can be drawn concerning doses regimens, but new insights showed an apparent benefit of IT gentamicin. | |
Casani et al. [42] | Open prospective, randomized, controlled study | IT gentamicin vs. IT steroid | IT gentamicin achieved better outcome than IT steroid in the control of vertigo attacks. |
Study | Study design | Diagnosis | Study protocol | Results |
---|---|---|---|---|
Topak et al. [47] | Prospective, randomized, controlled, single-blinded study | Refractory tinnitus | IT steroid vs. IT saline | IT steroid has no benefit, compared with placebo. |
Choi et al. [48] | Prospective, randomized, double-blind, controlled study | Refractory tinnitus | IT steroid vs. IT saline | IT steroid may not be effective for refractory tinnitus. |
Shim et al. [50] | Prospective, randomized, double-blind, controlled study | Acute subjective idiopathic tinnitus | Alprazolam vs. alprazolam+IT steroid | Alprazolam+IT steroid is the best treatment choice for acute tinnitus within 3 months of development. |
Albu et al. [49] | Prospective, randomized, double-blind, controlled study | Acute idiopathic tinnitus | Melatonin vs. melatonin+IT steroid | Melatonin+IT steroid is efficient in improvement of idiopathic unilateral tinnitus developed within 3 months. |
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