Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

Authors

  • Bridget Obiageli Onyema-iloh Department of Chemicalpathology, Nnamdi Azikiwe University Teaching Hospital Nnewi Anambra State
  • Samuel C Meludu Department of Human Biochemistry, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001 Nnewi, Anambra State
  • Emmanuel Iloh Department of Pure and Industrial Chemistry Anambra State University
  • Johnkennedy Nnodim Department of Medical Laboratory Science, Faculty of Health Science, Imo State University Owerri, Imo State
  • Onyema Onyegbule Department of Chemicalpathology, Nnamdi Azikiwe University Teaching Hospital Nnewi Anambra State
  • Blessing Mykembata Department of Chemicalpathology Benue State University

DOI:

https://doi.org/10.3126/ajms.v6i1.10799

Keywords:

Prostate cancer, Trace elements, Antioxidant vitamins, Biochemical changes

Abstract

Aim: This study was conducted to evaluate the serum levels of some trace-elements (zinc, copper and selenium) and antioxidant vitamins (vitamin A, C and E) in prostate cancer patients.

Method: A total of 50 prostate cancer patients aged 50-70 years with PSA > 4.0 ng/dl were recruited for the study while 50 apparently healthy individual were used as control subjects. Zinc, copper and selenium were determined using atomic absorption spectrophotometer while vitamin A, C and E were determined using high performance liquid chromatography.

Result: The result showed that the mean levels of Se (0.77±0.26), Zn(147.75±42.05) were significantly lower (p <0.05) when compared with the control (1.47±0.13) and (168.78±59.80) respectively. The serum copper level (187. 76±66.05) was significantly higher (p<0.05) when compared with control (126.40±31.24).The antioxidant vitamin A (0.42±0.19), vitamin C (3.62±1.81) and vitamin E (0.39±0.13) were Significantly lower p(<0.05) when compared with the control (0.68±0.32)(12.16±4.07) and (1.40±0.16) respectively.

Concusion: The decreased trace elements and antioxidant vitamins may be associated with high free radicals generated due to oxidative stress in prostate cancer patient.

DOI: http://dx.doi.org/10.3126/ajms.v6i1.10799

Asian Journal of Medical Sciences Vol.6(1) 2015 95-97

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Published

2014-07-25

How to Cite

Onyema-iloh, B. O., Meludu, S. C., Iloh, E., Nnodim, J., Onyegbule, O., & Mykembata, B. (2014). Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients. Asian Journal of Medical Sciences, 6(1), 95–97. https://doi.org/10.3126/ajms.v6i1.10799

Issue

Vol. 6 No. 1 (2015)

Section

Original Articles

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