VITAMIN D AND AUTOIMMUNE THYROIDITIS

Pivtorak K. V., Ivanhuk O. V

LITERATURE REVIEWS

Scentific article

An analysis of modern scientific literary sources about the mechanisms of the relationship between vitamin D deficiency, metabolic disorders and the development of autoimmune thyroiditis was carried out in this work. Over the past several decades, the importance of vitamin D in a variety of aspects unrelated to skeletal formation has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancer, and all-cause mortality. The extremely wide range of action of vitamin D is due to the presence of its receptors in many tissues. Vitamin D has an inhibiting effect on the production of inflammatory cytokines and tumor necrosis factor. In addition, vitamin D facilitates the induction of regulatory T cells to reduce T cell-dependent immune responses in autoimmune diseases. Patients with autoimmune thyroiditis have a high prevalence of vitamin D deficiency, which affects the frequency of hormonal dysfunction and the prognosis of the disease. The article highlights various variants of the pathogenesis of vitamin D deficiency and the development of autoimmune thyroiditis. It is generally known that the thyroid gland is an organ that is one of the leading parts of the neuroendocrine and immune system, the significant importance of which is carried out at various stages of a person’s life. Accumulated data indicate that a violation of the function of the thyroid gland leads to a violation of the metabolism in the body and affects the activity of almost all organs and systems. Scientific studies claim that vitamin D plays an important role in the formation of immune system responses in various autoimmune and inflammatory diseases, including autoimmune thyroiditis. It has been established that vitamin D takes part in the differentiation and formation of cells of various tissues and organs, as well as in the processes of forming the response of the immune system. Numerous studies have proven that a sufficient concentration of vitamin D in the body helps prevent the development of autoimmune disorders in various pathological conditions.

autoimmune thyroiditis,vitamin D,autoimmune diseases,metabolic-associated diseases,thyroid gland

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«Bulletin of problems biology and medicine» Issue 1 (168), 2023 year, 44-51 pages, index UDK 616.153.915-074:616.12-005.4+616.379-008.64

10.29254/2077-4214-2023-1-168-44-51