| About the author: |
K. V. Tykhonovych, K. S. Neporada, G. A. Yeroshenko |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to evaluate the effect of diabetic polyneuropathy on the development of pathological changes in the salivary glands of rats, as well as the feasibility of their correction by the drug Cocarnit. Immature white nonlinear rats of both sexes were simulated with streptozocin-induced diabetic neuropathy, which was confirmed by the Randall-Selitto tensoalgometric method. For correction, Cocarnit 1 mg/kg was administered intramuscularly for 9 days. The subjects were the submandibular salivary glands of rats. It was found that streptozocin-induced diabetic neuropathy leads to changes in the parenchymatous components in the lobules of submandibular salivary glands of rats, which was manifested by dystrophic and destructive changes in the epithelial cells of the terminal sections and ducts and blood perfusion in the hemomicrocirculatory vessels. Administration of Cocarnit reduces manifestations of periacinaric edema and improves trophism of epitheliocytes. Restoration of blood flow contributes to the normalization of secretory function of the glandular apparatus of submandibular salivary glands in rats. |
| Tags |
diabetic peripheral neuropathy,streptozocin,salivary glands,Cocarnit,nicotinamide,cobalamin,thiamine diphosphate |
| Bibliography |
- Blyshchak NB, Borys RY, Haliuk UM. Morfolohichna perebudova pidnyzhnoshchelepnoi zalozy shchuriv cherez 2 ta 4 tyzhni perebihu eksperymentalnoho tsukrovoho diabetu.. Klinichna anatomiia ta operatyvna khirurhiia. 2018. 3(17): 29–37. [in Ukrainian]
- Kotyk TL. Kharakterystyka perebudovy vyvidnykh protok pidnyzhnoshchelepnoi zalozy za umovy rozvytku eksperymentalnoho tsukrovoho diabetu z vykorystanniam analizu holovnykh component. Halytskyi likarskyi visnyk. 2015; 3(22): 108–112. [in Ukrainian]
- Nikitina N, Berehovyi S, Stepanova L, Kabanov O. Vyznachennia optymalnoi skhemy vvedennia Kokarnitu shchuram iz diabetychnoiu polineiropatiieiu za dopomohoiu tenzoalhometrychnoho metodu.. Visnyk Kyivskoho natsionalnoho universytetu imeni Tarasa Shevchenka. Problemy rehuliatsii fiziolohichnykh funktsii. 2017; 2(23):37–42. [in Ukrainian]
- Albers JW, Pop-Busui R. Diabetic neuropathy: mechanisms, emerging treatments, and subtypes. Curr Neurol Neurosci Rep. 2014;14:473. doi:10.1007/s11910-014-0473-5.
- Borgnakke WS, Anderson PF, Shannon C, Jivanescu A. Is there a relationship between oral health and diabetic neuropathy? Curr Diab Rep. 2015 Nov;15(11):93. doi: 10.1007/s11892-015-0673-7. PMID: 26374570.
- International Diabetes Federation. IDF Diabetes Atlas [Internet]. Available from: https://diabetesatlas.org/.
- Juster-Switlyk K and Smith AG. Updates in diabetic peripheral neuropathy [version 1; peer review: 3 approved]. F1000Research 2016, 5(F1000 Faculty Rev):738 (https://doi.org/10.12688/f1000research.7898.1)
- López-Pintor R, Casañas E, González-Serrano J, Serrano J, Ramírez L, Arriba L, Hernández G. (2016). Xerostomia, Hyposalivation, and Salivary Flow in Diabetes Patients. Journal of Diabetes Research. 2016. 1–15. 10.1155/2016/4372852.
- Pronina OM, Koptev MM, Bilash SM. Response of hemomicrocirculatory bed of internal organs on various external factors exposure based on the morphological research data, Svit medytsyny ta biologiyi. 2018; 1(63): 153–57. http://dx.doi.org/10.26.724/2079-8334-2018-1-63-153-157
- Santos-Nogueira E, Redondo Castro E, Mancuso R, Navarro X. Randall-Selitto Test: A New Approach for the Detection of Neuropathic Pain after Spinal Cord Injury. J Neurotrauma. 2012; 29(5): 898–904. doi: 10.1089/neu.2010.1700
- Shevchenko KV, Yeroshenko GA, Yakushko OS, Kazakova KS, Kramarenko DR. Morphometric description of the exchange segment of microvasculature of rats’ salivary glands in normal conditions and chronic ethanol intoxication. Wiadomości Lekarskie. 2019; 72(3): 323–26.,
- Velasco-Ortega E, Delgado-Ruiz RA, López-López J. Dentistry and Diabetes: The Influence of Diabetes in Oral Diseases and Dental Treatments. J Diabetes Res. 2016;2016:6073190. doi:10.1155/2016/6073190
- Yeroshenko GA, Shevchenko KV, Yakushko OS. Morphometric characteristics of rat salivary glands hemomicrovasculature capacity component under normal conditions and in ethanol chronic intoxication. World of medicine and biology. 2018;3(65):149–152.
|
| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 229-232 pages, index UDK 616.316-06:616.833-02:616.379.-008.64]-091/-092.9 |
| DOI |
10.26724/2079-8334-2023-1-83-229-232 |
