Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/86342
Title: Modulation of lymphocyte functions in the microenvironment by tumor oncogenic pathways
Author(s): Seliger, Barbara
Massa, Chiara
Issue Date: 2022
Type: Article
Language: English
Abstract: Despite the broad application of different immunotherapeutic strategies for the treatment of solid as well as hematopoietic cancers, the efficacy of these therapies is still limited, with only a minority of patients having a long-term benefit resulting in an improved survival rate. In order to increase the response rates of patients to the currently available immunotherapies, a better understanding of the molecular mechanisms underlying the intrinsic and/or extrinsic resistance to treatment is required. There exist increasing evidences that activation of different oncogenic pathways as well as inactivation of tumor suppressor genes (TSG) in tumor cells inhibit the immune cell recognition and influegnce the composition of the tumor microenvironment (TME), thus leading to an impaired anti-tumoral immune response. A deeper understanding of the link between the tumor milieu and genomic alterations of TSGs and oncogenes is indispensable for the optimization of immunotherapies and to predict the patients’ response to these treatments. This review summarizes the role of different cancer-related, oncogene- and TSG-controlled pathways in the context of anti-tumoral immunity and response to different immunotherapies.
URI: https://opendata.uni-halle.de//handle/1981185920/88295
http://dx.doi.org/10.25673/86342
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Frontiers in immunology
Publisher: Frontiers Media
Publisher Place: Lausanne
Volume: 13
Original Publication: 10.3389/fimmu.2022.883639
Appears in Collections:Open Access Publikationen der MLU

Files in This Item:
File Description SizeFormat 
fimmu-13-883639.pdf1.58 MBAdobe PDFThumbnail
View/Open