Abstract
Betulin, betulinic acid and their derived compounds are important pentacyclic lupane-type triterpenoids and exhibit diversified pharmacological activities like anti-HIV, antitumor, antimycotic, anti-inflammatory, antioxidant and immunomodulatory activities. Many new methods for the synthesis of potentially valuable betulin derived triterpenoids with potent bioactivity have been largely reported in the past few years. In this review, we will present the progress made on the synthesis of novel structural triterpenoids with excellent chemical or biological activity that have appeared from 2006 to 2012.
Keywords: Betulin, betulinic acid, heterocyclic derivatives, biological activity, synthetic method.
Mini-Reviews in Organic Chemistry
Title:Research and Development in Betulin and Betulinic Acid Derived Triterpenoids
Volume: 11 Issue: 3
Author(s): Wei Shi, Ning Tang and Weidong Yan
Affiliation:
Keywords: Betulin, betulinic acid, heterocyclic derivatives, biological activity, synthetic method.
Abstract: Betulin, betulinic acid and their derived compounds are important pentacyclic lupane-type triterpenoids and exhibit diversified pharmacological activities like anti-HIV, antitumor, antimycotic, anti-inflammatory, antioxidant and immunomodulatory activities. Many new methods for the synthesis of potentially valuable betulin derived triterpenoids with potent bioactivity have been largely reported in the past few years. In this review, we will present the progress made on the synthesis of novel structural triterpenoids with excellent chemical or biological activity that have appeared from 2006 to 2012.
Export Options
About this article
Cite this article as:
Shi Wei, Tang Ning and Yan Weidong, Research and Development in Betulin and Betulinic Acid Derived Triterpenoids, Mini-Reviews in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/1570193X1103140915112124
DOI https://dx.doi.org/10.2174/1570193X1103140915112124 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Small Molecules, Big Impact: Pioneering Approaches in Anti-inflammatory Care
This thematic issue is dedicated to the latest advancements and research breakthroughs in the realm of anti-inflammatory pharmacotherapy. With inflammation playing a critical role in numerous chronic conditions such as cardiovascular diseases, diabetes, and autoimmune disorders, there is an urgent need for more targeted, effective, and safer anti-inflammatory treatments. This ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Preventive and Therapeutic Role of Muscle Contraction Against Chronic Diseases
Current Pharmaceutical Design Alternative Splicing, DNA Damage and Modulating Drugs in Radiation Therapy for Cancer
Anti-Cancer Agents in Medicinal Chemistry Implication of Circadian Rhythms and Melatonin in Major Depressive Disorder: The Evidence Base for New Antidepressant Treatment
Current Psychiatry Reviews Adult Stem Cells for Cartilage Tissue Engineering and Regeneration
Current Rheumatology Reviews Gabapentin and Pregabalin for the Acute Post-operative Pain Management. A Systematic-narrative Review of the Recent Clinical Evidences
Current Drug Targets Electrical Impedance Scanning - A New Diagnostic Tool in Cancer Detection: Current Status and Recent Developments
Current Medical Imaging The c-Met Inhibitors: A New Class of Drugs in the Battle Against Advanced Nonsmall- Cell Lung Cancer
Current Pharmaceutical Design A Comprehensive Review on Combretastatin Analogues as Tubulin Binding Agents
Current Organic Chemistry Vitamin D and Lung Cancer
Current Respiratory Medicine Reviews Patent Selections
Recent Patents on Biotechnology Post-Exercise Ketosis, Salivary Uric Acid and Interleukin-6 after a Simulated Wheelchair Basketball Match
Endocrine, Metabolic & Immune Disorders - Drug Targets Protein Kinase R: A Novel Mediator of Articular Cartilage Degradation in Arthritis
Current Rheumatology Reviews Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review
Current Pharmaceutical Design Nitric Oxide-Releasing Biomaterials for Biomedical Applications
Current Medicinal Chemistry Selective Antitumor Effect of Shikonin Derived DMAKO-20 on Melanoma through CYP1B1
Current Cancer Drug Targets OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease
Current Immunology Reviews (Discontinued) Sugar Based Biopolymers in Nanomedicine; New Emerging Era for Cancer Imaging and Therapy
Current Topics in Medicinal Chemistry Current Perspectives on Anti-Aging Interventions
Letters in Drug Design & Discovery Natural Naphthoquinones with Great Importance in Medicinal Chemistry
Current Organic Synthesis Imaging Cellular Receptors in Breast Cancers: An Overview
Current Pharmaceutical Biotechnology