Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides

Title: Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides

Volume: 2 Issue: 6

Author(s): Yulin Ren, Yawei Zhou, Xiaozhuo Chen and Yunhua Ye

Affiliation:

Keywords: sesquiterpene lactone, guaianolides, mulgedium tatarica, anticancer activity, kb cells, bel 7402 cells

Abstract: We reported that the extract of Mulgedium tatarica DC. exhibits anticancer activity. With the help of a tumor cell killing bioassay, the sesquiterpene lactones lactucopicrin (1), 11,13β-dihydrolactucopicrin (2), lactucin (3) and 11,13β-dihydrolactucin (4) were isolated and identified from this medicinal herb. SAR studies indicate that the ester group at position 8 and the exocyclic methylene group at position 11 play a major role in anticancer activities of lactucin-like guaianolides, a kind of sesquiterpene lactone.

Cite this article as:

Ren Yulin, Zhou Yawei, Chen Xiaozhuo and Ye Yunhua, Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides, Letters in Drug Design & Discovery 2005; 2 (6) . https://dx.doi.org/10.2174/1570180054771581