Abstract
The last two decades are characterized by major increases in the incidence of systemic fungal infections caused by the yeast Candida albicans, particularly in immunocompromised patients. On the other hand it was observed the increased number of pathogenic microorganisms with multiple resistance to drugs. Also there is a big variety of drugs for the treatment of candidiasis, only two drugs are used for the treatment of infections from Aspergillus fumigatus. Taking into account that the long term therapy with azoles results in resistance a critical need exists for new antifungal agents with fewer side effecgts to treat these life-threatening fungal infections.
This review will cover the advances in research of biological activity of different compounds from different chemical classes with focus on their antifungal properties.
Keywords: Allylamines, antifungal, Aspergillosis, azoles, Candidiasis, thiazoles, thiazolidinones, thiophenes.
Current Topics in Medicinal Chemistry
Title:Synthesis and Biological Evaluation of Potent Antifungal Agents
Volume: 13 Issue: 21
Author(s): Athina Geronikaki, Maria Fesatidou, Victor Kartsev and Fliur Macaev
Affiliation:
Keywords: Allylamines, antifungal, Aspergillosis, azoles, Candidiasis, thiazoles, thiazolidinones, thiophenes.
Abstract: The last two decades are characterized by major increases in the incidence of systemic fungal infections caused by the yeast Candida albicans, particularly in immunocompromised patients. On the other hand it was observed the increased number of pathogenic microorganisms with multiple resistance to drugs. Also there is a big variety of drugs for the treatment of candidiasis, only two drugs are used for the treatment of infections from Aspergillus fumigatus. Taking into account that the long term therapy with azoles results in resistance a critical need exists for new antifungal agents with fewer side effecgts to treat these life-threatening fungal infections.
This review will cover the advances in research of biological activity of different compounds from different chemical classes with focus on their antifungal properties.
Export Options
About this article
Cite this article as:
Geronikaki Athina, Fesatidou Maria, Kartsev Victor and Macaev Fliur, Synthesis and Biological Evaluation of Potent Antifungal Agents, Current Topics in Medicinal Chemistry 2013; 13 (21) . https://dx.doi.org/10.2174/15680266113136660195
DOI https://dx.doi.org/10.2174/15680266113136660195 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Molecular Mapping and Docking Interactions for Selective Anti-Fertility Potency of Estrogen Analogs
Letters in Drug Design & Discovery Review of the Syntheses and Activities of Some Sulfur-Containing Drugs
Current Organic Synthesis Screening of 64 Tryptamines at NMDA, 5-HT1A, and 5-HT2A Receptors: A Comparative Binding and Modeling Study
Current Medicinal Chemistry Docking Simulations Exhibit Bortezomib and other Boron-containing Peptidomimetics as Potential Inhibitors of SARS-CoV-2 Main Protease
Current Chemical Biology Chalcone and Curcumin Derivatives: A Way Ahead for Malarial Treatment
Mini-Reviews in Medicinal Chemistry SARS-CoV-2 Infections, Impaired Tissue, and Metabolic Health: Pathophysiology and Potential Therapeutics
Mini-Reviews in Medicinal Chemistry Chemometric Modeling of 5-Phenylthiophenecarboxylic Acid Derivatives as Anti-Rheumatic Agents
Current Computer-Aided Drug Design Molecular Symmetry: A Structural Property Frequently Present in New Cytotoxic and Proapoptotic Drugs
Mini-Reviews in Medicinal Chemistry Opinion: “High-Dose Immunosuppression to Prevent Death after Paraquat Self-Poisoning”- Under Estimation of a Significant Effect with Small Mortality Rate Reduction
Current Rheumatology Reviews Second-Generation Antipsychotic Agents: A Review of Safety Profiles
Current Psychiatry Reviews Plant Natural Products as a Potential Source for Antibacterial Agents: Recent Trends
Anti-Infective Agents in Medicinal Chemistry Views on Amyloid Hypothesis and Secretase Inhibitors for Treating Alzheimers Disease: Progress and Problems
Current Pharmaceutical Design Chemoinformatics Approaches for Traditional Chinese Medicine Research and Case Application in Anticancer Drug Discovery
Current Drug Discovery Technologies Antibody-Drug Conjugate Targets
Current Cancer Drug Targets Exploiting High-Throughput Ion Channel Screening Technologies in Integrated Drug Discovery
Current Pharmaceutical Design Phytochemical Content and Potential Health Applications of Pecan [<i>Carya illinoinensis</i> (Wangenh) K. Koch] Nutshell
Current Topics in Medicinal Chemistry Isolation of Antibodies From Non-Human Primates for Clinical Use
Current Drug Discovery Technologies SARS: Understanding the Virus and Development of Rational Therapy
Current Molecular Medicine NGS Technologies as a Turning Point in Rare Disease Research , Diagnosis and Treatment
Current Medicinal Chemistry Antagonism by Bioactive Polyphenols Against Inflammation: A Systematic View
Inflammation & Allergy - Drug Targets (Discontinued)