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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Editorial

Nucleoside and Nucleotide Analogues as Potential Therapeutics

Author(s): Roza Pawlowska and Arkadiusz Chworos

Volume 30, Issue 11, 2023

Published on: 06 January, 2023

Page: [1207 - 1208] Pages: 2

DOI: 10.2174/092986733011230106124249

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[1]
Ariav, Y.; Ch’ng, J.H.; Christofk, H.R.; Ron-Harel, N.; Erez, A. Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response. Sci. Adv., 2021, 7(21), eabg6165.
[http://dx.doi.org/10.1126/sciadv.abg6165]
[2]
Kepp, O.; Loos, F.; Liu, P.; Kroemer, G. Extracellular nucleosides and nucleotides as immunomodulators. Immunol. Rev., 2017, 280(1), 83-92.
[http://dx.doi.org/10.1111/imr.12571]
[3]
Yegutkin, G.G. Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade. Biochim. Biophys. Acta, 2008, 1783, 673-694.
[4]
Pawlowska, R.; Korczynski, D.; Nawrot, B.; Stec, W.J.; Chworos, A. The α-thio and/or β-γ-hypophosphate analogs of ATP as cofactors of T4 DNA ligase. Bioorg. Chem., 2016, 67, 110-115.
[http://dx.doi.org/10.1016/j.bioorg.2016.06.003]
[5]
Poijärvi-Virta, P. Prodrug approaches of nucleotides and oligonucleotides. Curr. Med. Chem., 2006, 13(28), 3441-3465.
[http://dx.doi.org/10.2174/092986706779010270]
[6]
Jordheim, L.P.; Durantel, D.; Zoulim, F.; Dumontet, C. Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases. Nat. Rev. Drug Discov., 2013, 12(6), 447-464.
[http://dx.doi.org/10.1038/nrd4010]
[7]
Franczak, M.; Toenshoff, I.; Jansen, G.; Smolenski, R.T.; Giovannetti, E.; Peters, G.J. The influence of mitochondrial energy and 1C metabolism on the efficacy of anticancer drugs - exploring potential mechanisms of resistance. Curr. Med. Chem., 2023, 30(11), 1209-1231.
[http://dx.doi.org/10.2174/0929867329666220401110418]
[8]
Suwara, J.; Radzikowska-Cieciura, E.; Chworos, A.; Pawlowska, R. The ATP-dependent pathways and human diseases. Curr. Med. Chem., 2023, 30(11), 1232-1255.
[http://dx.doi.org/10.2174/0929867329666220322104552]
[9]
Roy, B.; Navarro, V.; Peyrottes, S. Prodrugs of nucleoside 5′-monophosphate analogues: Overview of the recent literature concerning their synthesis and applications. Curr. Med. Chem., 2023, 30(11), 1256-1303.
[http://dx.doi.org/10.2174/0929867329666220909122820]
[10]
Fàbrega, C.; Clua, A.; Eritja, R.; Aviñó, A. Oligonucleotides carrying nucleoside antimetabolites as potential prodrugs. Curr. Med. Chem., 2023, 30(11), 1304-1319.
[http://dx.doi.org/10.2174/0929867328666211129124039]
[11]
Graczyk, A.; Radzikowska-Cieciura, E.; Kaczmarek, R.; Pawlowska, R.; Chworos, A. Modified nucleotides for chemical and enzymatic synthesis of therapeutic RNA. Curr. Med. Chem., 2023, 30(11), 1320-1347.
[http://dx.doi.org/10.2174/0929867330666221014111403]

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