Abstract
SH3 domains are small but important domains in cell-signaling and function through protein-protein interactions. Their promiscuous nature in binding to polyproline peptides makes them much more important because many SH3 domains from different proteins bind to different proteins having polyproline template on their surface. Very subtle changes in the sequence of SH3 domains and the binding peptides determine the specificity of the peptide binding. Recent observation that SH3 domains bind to non- proline peptides makes the scenario of peptide binding involving SH3 domains complicated. If domain swapped dimerization as observed in Eps8-SH3 domain also binds different peptides, it proves the versatility of the SH3 domains in binding to peptides in various ways. An overview of the promiscuity of SH3 domains has been discussed.
Keywords: sh3 domain, sh3 domain binding, promiscuous binding, src domain
Protein & Peptide Letters
Title: Promiscuous Binding Nature of Sh3 Domains to their Target Proteins
Volume: 9 Issue: 3
Author(s): Vishal Agrawal and K.V. Radha Kishan
Affiliation:
Keywords: sh3 domain, sh3 domain binding, promiscuous binding, src domain
Abstract: SH3 domains are small but important domains in cell-signaling and function through protein-protein interactions. Their promiscuous nature in binding to polyproline peptides makes them much more important because many SH3 domains from different proteins bind to different proteins having polyproline template on their surface. Very subtle changes in the sequence of SH3 domains and the binding peptides determine the specificity of the peptide binding. Recent observation that SH3 domains bind to non- proline peptides makes the scenario of peptide binding involving SH3 domains complicated. If domain swapped dimerization as observed in Eps8-SH3 domain also binds different peptides, it proves the versatility of the SH3 domains in binding to peptides in various ways. An overview of the promiscuity of SH3 domains has been discussed.
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Cite this article as:
Agrawal Vishal and Kishan Radha K.V., Promiscuous Binding Nature of Sh3 Domains to their Target Proteins, Protein & Peptide Letters 2002; 9 (3) . https://dx.doi.org/10.2174/0929866023408760
DOI https://dx.doi.org/10.2174/0929866023408760 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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