An Awareness of Pharmacovigilance among Healthcare Professionals Due to an Underreporting of Adverse Drug Reactions Issue: A Systematic Review of the Current State, Obstacles, and Strategy

Title:An Awareness of Pharmacovigilance among Healthcare Professionals Due to an Underreporting of Adverse Drug Reactions Issue: A Systematic Review of the Current State, Obstacles, and Strategy

Volume: 19 Issue: 3

Author(s): Risani Andalasia Putri, Zullies Ikawati*, Fita Rahmawati and Nanang Munif Yasin

Affiliation:

• Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Street, Yogyakarta, Indonesia

Keywords: ADR, pharmacovigilance, HCP, underreporting factors, KAAP.

Abstract:

Background: Healthcare professionals play an essential role in reporting adverse drug reactions as part of pharmacovigilance activities. However, adverse drug reactions reported by healthcare professionals remain low.

Objective: The aim of this systematic review was to investigate healthcare professionals' knowledge, awareness, attitude, and practice on pharmacovigilance and adverse drug reaction reporting, explore the causes of the underreporting issue, and provide improvement strategies.

Methods: This systematic review was conducted using four electronic databases for original papers, including PubMed, Scopus, Google Scholar, and Scholar ID. Recent publications from 1^st January 2012 to 31^st Results: Twenty-five studies were selected for systematic review. This review found that 24.8%–73.33% of healthcare professionals were unaware of the National Pharmacovigilance Center. Around 20%–95.7% of healthcare professionals have a positive attitude toward pharmacovigilance and adverse drug reaction reporting, while 12%–60.8% of healthcare professionals have experience reporting any adverse drug reaction in their practice. The most frequently highlighted barriers to pharmacovigilance were a lack of awareness and knowledge regarding what, when, and to whom to report.

Conclusion: Underreporting issues require immediate attention among healthcare professionals due to a lack of awareness and knowledge of pharmacovigilance and adverse drug reaction reporting. Educational and training program interventions have been suggested by most studies to address these issues.

Cite this article as:

Putri Andalasia Risani, Ikawati Zullies*, Rahmawati Fita and Yasin Munif Nanang, An Awareness of Pharmacovigilance among Healthcare Professionals Due to an Underreporting of Adverse Drug Reactions Issue: A Systematic Review of the Current State, Obstacles, and Strategy, Current Drug Safety 2024; 19 (3) . https://dx.doi.org/10.2174/0115748863276456231016062628