Objective To explore the clinical value of bispectral index (BIS) monitoring in children with electronic bronchoscopy in pediatric intensive care unit (PICU).Methods 107 children with respiratory diseases were selected for electronic bronchoscopy. Randomly divided into control group (51 cases) and observation group (56 cases). Two groups were given ECG monitoring, sufentanil combined with propofol for analgesia and sedation in the process of electronic bronchoscopy.Judging the degree of anesthesia by the clinical experience in the control group, the observation group judged by BIS. Record the heart rate, mean arterial pressure and blood oxygen saturation of two groups before, during and after the operation. Comparing the postoperative recovery time and the incidence of adverse reactions of coughing and vomiting between the two groups.Results The SpO₂ of the observation group was significantly higher than that in the control group at T₁ and T₂ (P < 0.05). The postoperative recovery time and the incidence of adverse reactions of the observation group were lower than those in the control group (P < 0.05). The incidence of interruption operation and the second operation of the observation group was significantly lower than that in the control group, duing to hypoxemia (P < 0.05).Conclusion BIS can effectively monitor the depth of anesthesia in critical children with electronic bronchoscopy, complete the diagnosis and treatment of electronic bronchoscopy, reduce the incidence of adverse reactions.