Abstract: The Yarlung Zangbo River basin (YZRB) is a major agricultural area on the Tibetan Plateau．Analysis of dynamic changes of YZRB farmland pattern and influencing factors is of great significance to ensure self-sufficiency of grain and stable development of social environment in Tibet．The 30 m land use data were used in geodetector and geographically weighted logistic regression to analyze farmland requisition-compensation dynamic and influencing factors in YZRB from 2000 to 2015．Farmland requisition was found to have mainly occurred in peri-urban area of Lhasa (60.42%), Nyingchi (16.21%), and Lhoka (13.01%), mostly have transformed into waters and urban areas．Farmland compensation mainly distributed in Xigaze (55.81%), Nyingchi (23.26%), and Lhasa (19.61%), mostly from forest and grassland．Economic development, transportation infrastructure, and administrative factors mainly influenced farmland requisition．Investment, administrative and elevation factors mainly influenced farmland compensation．Spatial stratified heterogeneity was apparent in driving factors of farmland dynamics．Labor force transfer, tourism development, and backward farming concepts were main farmland development problems faced by Xigaze, Lhasa, and Nyingchi, respectively．This study elucidates farmland requisition-compensation dynamic and could guide high-quality coordinated development of agriculture in the Tibetan Plateau．The reserve farmland in the suburbs of Lhasa and Nyingchi should be protected, while agricultural policy tendencies such as capital and technical training should be given in Xigaze, to realize differential protection and management of farmland in the YZRB．