Abstract: In this experiment, amphiphilice polyhydroxyalkanoate (PHA) particle surface binding protein (PhaP) was synthesized and purified. PhaP was effectively modified on the surface of curcumin nanosphere (Cur@PHA), and the dispersion performance of nanosphere was effectively improved by surface modification. The morphology, stability, drug release and in vitro cytotoxicity of the drug delivery system of Cur-PhaP@PHA were characterized and analyzed. The results showed that Cur-PhaP@PHA had good sphericity, excellent light stability, and sustained and controlled release. It also exhibited better drug absorption and bioavailability than free curcumin. This comprehensive experimental design is based on industrial demand, inspiring students to analyze and solve problems from the perspective of industrial application and technological innovation, which is conducive to improving students’ comprehensive innovation ability.