The integration of general education and professional education is a requirement for higher education in China with the economic and social development, but also an inevitable choice for higher education to adapt to the economic and social development actively. In new era, the integration of general education and professional education cannot develop independently without innovative education, and it should be guided with the innovate education. From the perspective of spawning innovation consciousness, cultivating innovative thinking, encouraging innovative behavior and shaping innovative personality, a new way of integration of general education and professional education should be explored. Finally, the "cross" top-notch innovative talents with higher quality will be cultivated.