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Antibodies in horses, mules and donkeys following monovalent vaccination against African horse sickness

Published online by Cambridge University Press:  15 May 2009

C. Hamblin ,
P. S. Mellor ,
S. D. Graham ,
H. Hooghuis ,
R. C. Montejano ,
M. A. Cubillo  and
J. Boned
C. Hamblin
Affiliation:
AFRC Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey, GU24 0NF
P. S. Mellor
Affiliation:
AFRC Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey, GU24 0NF
S. D. Graham
Affiliation:
AFRC Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey, GU24 0NF
H. Hooghuis
Affiliation:
Laboratorio de Sanidad Y Produccion Animal, Ctra. Madrid-Irun Desv. Algete, Km 5400, 28110 Madrid, Spain
R. C. Montejano
Affiliation:
Laboratorio de Sanidad Y Produccion Animal, Ctra. Madrid-Irun Desv. Algete, Km 5400, 28110 Madrid, Spain
M. A. Cubillo
Affiliation:
Laboratorio de Sanidad Y Produccion Animal, Ctra. Madrid-Irun Desv. Algete, Km 5400, 28110 Madrid, Spain
J. Boned
Affiliation:
Junta de Andalucia, Laboratorio de Sanidad Y Produccion Animal, Apartado Correos 259, 14080 Codoba, Spain
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Summary

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A total of 256 sera collected from three species of domesticated equidae in four different Spanish provinces were examined 1–4 months after the administration of attenuated monovalent African horse sickness virus (AHSV) serotype 4 vaccine. Approximately 10% of the sera were negative by ELISA, virus neutralization, agar gel immuno-diffusion and complement fixation tests. Similar negative reactions were recorded with sera from two ponies after experimental primary vaccination. The rapid rise in antibodies in sera from these two ponies, after a second dose of vaccine, suggested they would probably have been immune to challenge. It is therefore suggested that the apparent absence of antibodies against AHSV in some animals after primary vaccination may not necessarily indicate a total lack of protection.

Type
Special Article
Information
Epidemiology & Infection , Volume 106 , Issue 2 , April 1991 , pp. 365 - 371
Copyright
Copyright © Cambridge University Press 1991

References

REFERENCES

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